Molecular Neurobiology,
Journal Year:
2018,
Volume and Issue:
55(10), P. 7987 - 8000
Published: Feb. 28, 2018
The
gut-brain
axis
is
a
bidirectional
communication
network
functionally
linking
the
gut
and
central
nervous
system
(CNS).
Based
on
this,
rational
manipulation
of
intestinal
microbiota
represents
novel
attractive
therapeutic
strategy
for
treatment
CNS-associated
disorders.
In
this
study,
we
explored
properties
probiotic
formulation
(namely
SLAB51)
in
counteracting
brain
oxidative
damages
associated
with
Alzheimer's
disease
(AD).
Specifically,
transgenic
AD
mice
(3xTg-AD)
were
treated
SLAB51
effects
protein
oxidation,
neuronal
antioxidant
defence
repair
systems
monitored,
particular
focus
role
SIRT1-related
pathways.
We
demonstrated
that
markedly
reduced
stress
by
activating
SIRT1-dependent
mechanisms,
thus
representing
promising
adjuvant
treatment.
Chemical Reviews,
Journal Year:
2018,
Volume and Issue:
118(18), P. 8798 - 8888
Published: Aug. 27, 2018
The
concept
of
cell
signaling
in
the
context
nonenzyme-assisted
protein
modifications
by
reactive
electrophilic
and
oxidative
species,
broadly
known
as
redox
signaling,
is
a
uniquely
complex
topic
that
has
been
approached
from
numerous
different
multidisciplinary
angles.
Our
Review
reflects
on
five
aspects
critical
for
understanding
how
nature
harnesses
these
noncanonical
post-translational
to
coordinate
distinct
cellular
activities:
(1)
specific
players
their
generation,
(2)
physicochemical
properties,
(3)
mechanisms
action,
(4)
methods
interrogation,
(5)
functional
roles
health
disease.
Emphasis
primarily
placed
latest
progress
field,
but
several
classical
work
likely
forgotten/lost
are
also
recollected.
For
researchers
with
interests
getting
into
our
anticipated
function
primer.
expert,
we
aim
stimulate
thought
discussion
about
fundamentals
nuances
specificity/selectivity
timing
this
sophisticated
yet
fascinating
arena
at
crossroads
chemistry
biology.
Frontiers in Plant Science,
Journal Year:
2017,
Volume and Issue:
8
Published: May 23, 2017
Many
plants,
including
some
of
the
commonly
consumed
herbs
and
spices
in
our
daily
food,
can
be
safely
effectively
used
to
prevent
and/or
treat
health
concerns.
For
example,
caffeine
active
ingredient
found
coffee
beans
(Coffea),
shows
biological
activity
treatment
central
nervous
system
(CNS)
disorders,
indole-3-carbinol,
3,3'-diindolylmethane
are
both
broccoli
(Brassica
oleracea)
derived
phytochemicals
with
potential
anti-cancer
activity,
resveratrol,
isolated
from
grape
(Vitis
vinifera),
is
reported
extend
lifespan
provide
cardio-neuro-protective,
anti-diabetic,
effects.
Date
palm
fruits
possess
high
nutritional
therapeutic
value
significant
antioxidant,
antibacterial,
antifungal,
anti-proliferative
properties.
This
review
focuses
on
date
fruit
extracts
their
benefits
individual
promoting
conditions
highlights
applications
as
useful
pharmaceutical
nutraceutical
industries
development
natural
compound-based
industrial
products.
International Journal of Molecular Medicine,
Journal Year:
2018,
Volume and Issue:
unknown
Published: Jan. 19, 2018
Oxidative
stress
is
increasingly
recognized
as
a
central
event
contributing
to
the
degeneration
of
dopaminergic
neurons
in
pathogenesis
Parkinson's
disease
(PD).
Although
reactive
oxygen
species
(ROS)
production
implicated
causative
factor
PD,
cellular
and
molecular
mechanisms
linking
oxidative
with
neuron
death
are
complex
not
well
characterized.
The
primary
insults
cause
greatest
ROS,
which
contributes
damage
by
attacking
all
macromolecules,
including
lipids,
proteins
nucleic
acids,
leading
defects
their
physiological
function.
Consequently,
these
macromolecules
result
mitochondrial
dysfunction
neuroinflammation,
subsequently
enhance
ROS
ultimately
neuronal
damage.
interaction
between
various
forms
positive
feedback
loop
that
drives
progressive
loss
stress‑mediated
appears
serve
role
neurodegenerative
process.
Thus,
understanding
may
provide
promising
therapeutic
approach
PD
treatment.
Frontiers in Molecular Biosciences,
Journal Year:
2019,
Volume and Issue:
6
Published: Oct. 18, 2019
Various
internal
and
external
factors
negatively
affect
the
homeostatic
equilibrium
of
organisms
at
molecular
to
whole-body
level,
inducing
so-called
state
'stress'.
Stress
affects
an
organism's
welfare
status
induces
energy-consuming
mechanisms
combat
subsequent
ill
effects;
thus,
individual
may
be
immunocompromised,
making
them
vulnerable
pathogens.
The
information
presented
here
has
been
extensively
reviewed,
compiled
analyzed
from
authenticated
published
resources
available
on
Medline,
Pubmed,
Pubmed
Central,
Science
Direct,
other
scientific
databases.
levels
can
monitored
by
quantitative
qualitative
measurement
biomarkers.
Prominent
markers
stress
include
thermal
like
heat
shock
proteins
(HSPs),
innate
immune
Acute
Phase
Proteins
(APPs),
oxidative
markers,
chemical
secretions
in
saliva
urine.
In
addition,
biomarkers
are
thought
play
critical
roles
prognosis
stress-related
diseases
disorders,
therapy
guidance.
Moreover,
different
components
have
identified
as
potent
mediators
cardiovascular,
central
nervous
system,
hepatic,
nephrological
which
also
employed
evaluate
these
conditions
precisely,
but
with
stringent
validation
specificity.
Considerable
advances
made
detection,
quantitation,
application
present
review
describes
current
progress
identifying
biomarkers,
their
prognostic
therapeutic
values.
Mitochondrion,
Journal Year:
2020,
Volume and Issue:
53, P. 214 - 223
Published: June 13, 2020
Mitochondrial
DNA
copy
number
(mtDNA-CN)
is
a
biomarker
of
mitochondrial
function
and
levels
mtDNA-CN
have
been
reproducibly
associated
with
overall
mortality
age-related
diseases,
including
cardiovascular
disease,
chronic
kidney
cancer.
Recent
advancements
in
techniques
for
estimating
mtDNA-CN,
particular
the
use
microarrays
next-generation
sequencing
data,
led
to
comprehensive
assessment
across
these
other
diseases
traits.
The
importance
measures
disease
advancing
technologies
suggest
potential
be
useful
clinic.
While
exact
mechanism(s)
underlying
association
remain
elucidated,
we
review
existing
literature
which
supports
roles
inflammatory
dynamics,
immune
alterations
cell
signaling
as
consequences
variation
mtDNA-CN.
We
propose
that
future
studies
should
focus
on
characterizing
longitudinal,
cell-type
cross-tissue
profiles
well
improving
methods
measuring
will
expand
its
clinical
biomarker.
