Fosfenopril Attenuates Inflammatory Response in Diabetic Dry Eye Models by Inhibiting the TLR4/NF-κB/NLRP3 Signaling Pathway DOI Creative Commons
Kaiwen Jiang, Fenglan Zhang, Ying Chen

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(6), P. 2 - 2

Published: June 3, 2024

Purpose: The purpose of this study was to investigate the involvement TLR4/NF-κB/NLRP3 signaling pathway and its underlying mechanism in diabetic dry eye. Methods: Two models eye were established high glucose-induced human corneal epithelial (HCE-T) cells streptozotocin (STZ)-induced C57BL/6 mice, TLR4 inhibitor fosfenopril (FOS) utilized suppress pathway. expression changes TLR4, NF-κB, NLRP3, IL-1β, other factors detected by Western blot RT‒qPCR, wound healing rate evaluated cell scratch assay, symptoms mice sodium fluorescein staining tear secretion assay. Results: In model, transcript levels IL-1β raised, further application FOS, a inhibitor, downregulated these factors. addition, FOS found be effective increasing HCE-T cells, production, decreasing fluorescence scores as measured production. Conclusions: current that regulates an vitro vivo reduces signs providing new treatment option for

Language: Английский

Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds DOI
Yuan Xiong, Xiangyu Chu, Tao Yu

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)

Published: April 13, 2023

Diabetic wounds are characterized by drug-resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, oxidative damage to the microenvironment. Given their complex nature, diabetic remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown trigger hyperinflammation excessive cellular apoptosis, play pivotal role pathogenesis of wounds. ROS-scavenging nanosystems recently emerged as smart multifunctional nanomedicines with broad synergistic applicability. The documented anti-inflammatory pro-angiogenic ability treatments predestines these promising options for treatment Yet, this context, therapeutic applicability efficacy be elucidated. Herein, ROS is deciphered, properties strengths capacity summarized. In addition, current challenges such potential future directions discussed through clinical-translational lens.

Language: Английский

Citations

94
Metal–Organic Frameworks and Their Composites for Chronic Wound Healing: From Bench to Bedside DOI Open Access
Yuan Xiong, Qian Feng, Li Lü

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Aug. 1, 2023

Chronic wounds are characterized by delayed and dysregulated healing processes. As such, they have emerged as an increasingly significant threat. The associated morbidity socioeconomic toll clinically financially challenging, necessitating novel approaches in the management of chronic wounds. Metal-organic frameworks (MOFs) innovative type porous coordination polymers, with low toxicity high eco-friendliness. Documented anti-bacterial effects pro-angiogenic activity predestine these nanomaterials promising systems for treatment In this context, therapeutic applicability efficacy MOFs remain to be elucidated. It is, therefore, reviewed structural-functional properties their composite materials discusses how multifunctionality customizability can leveraged a clinical therapy

Language: Английский

Citations

74
The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in diabetic retinopathy DOI Creative Commons
Xiaoqin Zheng,

Jia Wan,

Gang Tan

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 25, 2023

In the working-age population worldwide, diabetic retinopathy (DR), a prevalent complication of diabetes, is main cause vision impairment. Chronic low-grade inflammation plays an essential role in DR development. Recently, concerning pathogenesis DR, Nod-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome retinal cells has been determined as causal factor. eye, NLRP3 activated by several pathways (such ROS and ATP). The activation NPRP3 leads to secretion inflammatory cytokines interleukin-1β (IL-1β) interleukin-18 (IL-18), pyroptosis, rapid form lytic programmed cell death (PCD). Cells that undergo pyroptosis swell rapture, releasing more factors accelerating progression. This review focuses on mechanisms activate leading DR. present research highlighted some inhibitors NLRP3/pyroptosis novel therapeutic measures treatment.

Language: Английский

Citations

57
Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing DOI Creative Commons

Yuheng Liao,

Zhenhe Zhang,

Yanzhi Zhao

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 131 - 151

Published: Oct. 15, 2024

Language: Английский

Citations

22
Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity DOI Creative Commons
Kang Huang, Bobin Mi, Yuan Xiong

et al.

Burns & Trauma, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 1, 2025

Abstract Diabetes mellitus, a pervasive chronic metabolic disorder, is often associated with complications such as impaired wound healing. Various factors, most notably vascular deficiency, govern the repair process in diabetic patients, significantly impeding healing; therefore, angiogenesis and its role have emerged important areas of research. This review aims to delve into mechanisms angiogenesis, effects diabetes on association between repair. will ultimately offer valuable guidance regarding ideal timing treatment clinical setting.

Language: Английский

Citations

4
Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation DOI
Mengliang Wu, Lisa J. Hill, Laura E. Downie

et al.

Progress in Retinal and Eye Research, Journal Year: 2022, Volume and Issue: 91, P. 101105 - 101105

Published: July 19, 2022

Language: Английский

Citations

48
Mechanistic investigations of diabetic ocular surface diseases DOI Creative Commons
Qingjun Zhou, Lingling Yang,

Qun Wang

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 16, 2022

With the global prevalence of diabetes mellitus over recent decades, more patients suffered from various diabetic complications, including ocular surface diseases that may seriously affect quality life and even vision sight. The major include keratopathy dry eye. Diabetic is characterized with delayed corneal epithelial wound healing, reduced nerve density, decreased sensation feeling burning or dryness. eye manifested as reduction tear secretion accompanied discomfort. early clinical symptoms degeneration, suggesting diagnosis should be focused on examination confocal microscopy symptoms. pathogenesis involves accumulation advanced glycation end-products, impaired neurotrophic innervations limbal stem cell function, dysregulated growth factor signaling, inflammation alterations. associated abnormal mitochondrial metabolism lacrimal gland caused by overactivation sympathetic nervous system. Considering important roles dense in homeostatic maintenance cornea gland, further studies neuroepithelial neuroimmune interactions will reveal predominant pathogenic mechanisms develop targeting intervention strategies complications.

Language: Английский

Citations

42
Research progress of targeting NLRP3 inflammasome in peripheral nerve injury and pain DOI
Wei Li, Jie Liang, Shaohua Li

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 110, P. 109026 - 109026

Published: July 22, 2022

Language: Английский

Citations

39
The Interplay between Immune and Metabolic Pathways in Kidney Disease DOI Creative Commons
Lili Qu, Baihai Jiao

Cells, Journal Year: 2023, Volume and Issue: 12(12), P. 1584 - 1584

Published: June 8, 2023

Kidney disease is a significant health problem worldwide, affecting an estimated 10% of the global population. encompasses diverse group disorders that vary in their underlying pathophysiology, clinical presentation, and outcomes. These include acute kidney injury (AKI), chronic (CKD), glomerulonephritis, nephrotic syndrome, polycystic disease, diabetic many others. Despite distinct etiologies, these share common feature immune system dysregulation metabolic disturbances. The pathways are intimately connected interact to modulate pathogenesis diseases. responses diseases includes complex interplay between various cell types, including resident infiltrating cells, cytokines, chemokines, complement factors. factors can trigger perpetuate inflammation, causing renal tissue progressive fibrosis. In addition, play critical roles diseases, glucose lipid metabolism, oxidative stress, mitochondrial dysfunction, altered nutrient sensing. Dysregulation contributes progression by inducing tubular injury, apoptosis, Recent studies have provided insights into intricate revealing novel therapeutic targets for prevention treatment Potential strategies modulating through targeting key or inhibiting pro-inflammatory signaling pathways, improving function, nutrient-sensing such as mTOR, AMPK, SIRT1. This review highlights importance potential implications pathways.

Language: Английский

Citations

30
Tetrahedral Framework Nucleic Acids Based Small Interfering RNA Targeting Receptor for Advanced Glycation End Products for Diabetic Complications Treatment DOI
Zhengwen Cai, Yong Li, Long Bai

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(22), P. 22668 - 22683

Published: Sept. 26, 2023

Complications arising from diabetes can threaten multiple organs. Advanced glycation end products (AGEs) play a significant role in inducing these complications. Highly processed diets and hyperglycemia facilitate the accumulation of AGEs body. Interaction between their main receptor (RAGE) initiates transmission intracellular inflammatory cell death signals, which ultimately lead to To counter AGEs-induced damage, we developed an siRNA-binding tetrahedral framework nucleic acids (TDN) system, termed Tsi, combines potent membrane penetrability serum stability TDN with gene-targeting specificity siRNA-RAGE. Tsi effectively persistently downregulates expression RAGE, thereby suppressing inflammation by blocking NF-κB pathway as well exhibiting antioxidant functions. Furthermore, regulates pyroptosis state macrophages via NLRP3/caspase-1 axis, inhibits spread signals maintains homeostasis. This is great significance for synergistic treatment strategy systemic complications patients refractory hyperglycemia. In summary, this study describes nanomedicine that targets RAGE suppresses AGE-induced inflammation. acid drug holds long-lasting efficacy independent lowering hyperglycemia, provides diabetic age-related diseases.

Language: Английский

Citations

28