Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 167, P. 104403 - 104403
Published: Dec. 3, 2024
Language: Английский
Schizophrenia Bulletin, Journal Year: 2023, Volume and Issue: 50(3), P. 600 - 614
Published: Dec. 12, 2023
Abstract Background and Hypothesis Schizophrenia (SCZ) is a multifaceted mental disorder marked by spectrum of symptoms, including hallucinations, delusions, cognitive deficits, negative symptoms. Its etiology involves intricate interactions between genetic environmental factors, posing significant challenges for effective treatment. We hypothesized that intranasal administration exosomes derived from nasal olfactory mucosal mesenchymal stem cells (OM-MSCs-exos) could alleviate SCZ-like behaviors in murine model induced methylazoxymethanol (MAM). Study Design conducted comprehensive investigation to assess the impact intranasally delivered OM-MSC-exos on MAM-induced mice. This study encompassed behavioral assessments, neuroinflammatory markers, glial activation, synaptic protein expression, neurogenesis within hippocampus. Results Our findings demonstrated effectively ameliorated behaviors, specifically addressing social withdrawal sensory gating deficits model. Furthermore, intervention yielded reduction markers suppression microglial activation Simultaneously, we observed an upregulation key PSD95 TH, rate-limiting enzyme dopamine biosynthesis. Conclusions underscores therapeutic potential mitigating behavior. The have capacity modulate cell diminish neuroinflammation, promote BDNF-associated plasticity neurogenesis, thus ameliorating behaviors. In summary, offers approach address SCZ mechanisms, promising innovative treatments this disorder.
Language: Английский
Citations
16
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 10, 2024
Resistance of cancer cells to anticancer drugs remains a major challenge in modern medicine. Understanding the mechanisms behind development chemoresistance is key developing appropriate therapies counteract it. Nowadays, with advances technology, we are paying more and attention role tumor microenvironment (TME) intercellular interactions this process. We also know that important elements TME not only themselves but other cell types, such as mesenchymal stem cells, cancer-associated fibroblasts, stromal macrophages. can communicate each indirectly (via cytokines, chemokines, growth factors, extracellular vesicles [EVs]) directly gap junctions, ligand-receptor pairs, adhesion, tunnel nanotubes). This communication appears be critical for chemoresistance. EVs seem particularly interesting structures regard. Within these structures, lipids, proteins, nucleic acids transported, acting signaling molecules interact numerous biochemical pathways, thereby contributing Moreover, drug efflux pumps, which responsible removing from transported via EVs.
Language: Английский
Citations
6
Biological Procedures Online, Journal Year: 2024, Volume and Issue: 26(1)
Published: May 27, 2024
Abstract Exosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. can be derived from cells well cellular components tumor microenvironment. After secretion, the exosomes carrying a wide range bioactive cargos ingested by local or distant recipient cells. The released act through variety mechanisms to elicit multiple biological effects and impact most if not all hallmarks cancer. Moreover, owing their excellent biocompatibility capability being easily engineered modified, currently exploited promising platform for targeted therapy. In this review, we first summarize current knowledge roles risk etiology, initiation progression cancer, underlying molecular mechanisms. aptamer-modified exosome therapy is then briefly introduced. We also discuss future directions emerging biology perspective
Language: Английский
Citations
5
Technology and Health Care, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Uveal melanoma (UM) is a common intraocular malignancy in adults frequently with metastasis and poor survival. This study aimed to identify genes, pathways the ceRNA axes related of UM. The GSE73652 dataset was downloaded 1719 differentially expressed RNAs (DE-RNAs), including 13 lncRNAs, 5 miRNAs, 1701 were identified metastatic UM samples compared non-metastatic ones. A total 11 lncRNA-miRNA pairs by interviewing DIANA-LncBase database. In addition, 49 UM-related KEGG filtered CTD search term "uveal melanoma". involving genes (DEGs) among miRNA targets found overlapped pathways. Accordingly, two crucial (Wnt Chemokine signaling pathway) mediated consisting 6 lncRNAs (such as H19, PVT1 SNGHG1), 3 miRNAs (including hsa-miR-1228, hsa-miR-106b hsa-miR-6836) 12 mRNAs CTNNB1, MAP3K7, WNT7B, MAPK10 PLCB4). results showed that involvement Wnt/β-catenin regulatory noteworthy interest metastasis.
Language: Английский
Citations
0
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 168 - 168
Published: Jan. 12, 2025
Background/Objectives: It remains challenging to treat recurrent ovarian cancer effectively as traditional interventions like chemotherapy and surgery have limited long-term efficacy, highlighting an urgent need for innovative approaches. Immunotherapy offers potential advantages in modulating the immune response against tumor cells has emerged a promising strategy management. This review discusses various immunotherapy modalities, including active passive strategies, cancer. Methods: We systematically reviewed recent advances cancer, efficacy mechanisms of single dual checkpoint inhibitors, inhibitor combinations with or radiotherapy, anti-angiogenic agents, PARP antibody–drug conjugates (ADC), vaccines, adoptive cell therapies (ACT). Additionally, we assessed emerging research on biomarkers predictive responsiveness Results: The findings indicate that immunotherapy, particularly involving inhibitors other demonstrates some showing enhanced benefits specific subtypes. microenvironment platinum-sensitive -resistant cases exhibits distinct immunological profiles, influencing therapy outcomes. Several been identified, potentially aiding patient stratification treatment optimization. Conclusions: significantly treatment, improving Further characteristics is crucial personalizing approaches enhancing their managing
Language: Английский
Citations
0
Cancer Gene Therapy, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Language: Английский
Citations
0
Advances in Medical Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Extracellular Vesicles and Circulating Nucleic Acids, Journal Year: 2025, Volume and Issue: 6(1), P. 112 - 27
Published: Feb. 24, 2025
The role of extracellular vesicles (EVs) in mediating chemoresistance has gained significant attention due to their ability transfer bioactive molecules between drug-resistant and drug-sensitive cells. In particular, they have been demonstrated play an active part breast cancer by the horizontal genetic protein material. This review highlights EVs, particularly miRNA cargo, driving drug resistance cancer. EVs derived from chemoresistant cells carry miRNAs lncRNAs, which are known modulate gene networks involved cell proliferation survival. These cargo suppress apoptosis targeting pro-apoptotic genes like PTEN BIM, promote epithelial-mesenchymal transition (EMT) through regulation pathways such as TGF-β Wnt/b-catenin, contribute tumor growth enhancing angiogenesis modulating microenvironment. Beyond RNA-mediated effects, also functional proteins, including P-glycoprotein Hsp70, impact cellular metabolism survival pathways. Our findings underscore significance chemoresistance, suggesting potential involvement possible prognostic factors predict therapy response therapeutic targets combination with usual therapy.
Language: Английский
Citations
0
Radiation Oncology, Journal Year: 2023, Volume and Issue: 18(1)
Published: Nov. 7, 2023
Radiotherapy is widely used in treating cervical cancer patients, however, radioresistance unavoidably occurs and seriously affects the treatment effect. It well known that hypoxia plays an important role promoting tumor microenvironment, yet our understanding of effect small extracellular vesicles miRNA on radiosensitivity hypoxic environment still limited.Small extracted from normoxic cultured cells were evaluated for their effects radioresistance. miR-152-3p was found to be a potential effector hypoxia-derived by searching GEO database. Its downstream substrate confirmed double luciferase report, which KLF15. The KLF15 regulating detected cell activity assays. findings vivo animal models. expression quantified qRT-PCR its prognostic significance evaluated.Hypoxic promoted secretion vesicles, reduced apoptosis DNA damage caused radiation, accompanied increased cells. Furthermore, Hela xenograft growth vivo. Mechanism studies revealed protein target radioresistance.Our suggest therapeutic radiotherapy holds as biomarker or prognosis improving radiotherapy.
Language: Английский
Citations
10
Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: unknown, P. 101170 - 101170
Published: Dec. 1, 2024
Language: Английский
Citations
3