Breast cancer: Biology, biomarkers, and treatments

International Immunopharmacology, Journal Year: 2020, Volume and Issue: 84, P. 106535 - 106535

Published: April 29, 2020

Language: Английский

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Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 47(10), P. 3574 - 3620

Published: Jan. 1, 2018

Peptide- and protein-nanoparticle conjugates have emerged as powerful tools for biomedical applications, enabling the treatment, diagnosis, prevention of disease. In this review, we focus on key roles played by peptides proteins in improving, controlling, defining performance nanotechnologies. Within framework, provide a comprehensive overview sequences structures utilised to biological physical stability nano-constructs, direct particles their target influence cellular tissue distribution, induce control responses, form polypeptide self-assembled nanoparticles. doing so, highlight great advances made field, well challenges still faced achieving clinical translation peptide- protein-functionalised nano-drug delivery vehicles, imaging species, active therapeutics.

Language: Английский

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Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Feb. 3, 2021

Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate pharmacological and biopharmaceutical properties drugs. The peculiar physico-chemical technological nanomaterial-based therapeutics allowed for several successful applications treatment cancer. size, shape, charge patterning nanoscale therapeutic molecules are parameters that need be investigated modulated order promote optimize cell tissue interaction. In this review, use polymeric nanoparticles as drug delivery systems anticancer compounds, their ability efficiently localized specific tumor tissues been described. nanoencapsulation antitumor active compounds is a promising approach improve efficacy various treatments.

Language: Английский

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The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

Molecular Pharmaceutics, Journal Year: 2021, Volume and Issue: 18(5), P. 1862 - 1894

Published: March 31, 2021

Albumin is an appealing carrier in nanomedicine because of its unique features. First, it the most abundant protein plasma, endowing high biocompatibility, biodegradability, nonimmunogenicity, and safety for clinical application. Second, albumin chemical structure conformation allows interaction with many different drugs, potentially protecting them from elimination metabolism vivo, thus improving their pharmacokinetic properties. Finally, can interact receptors overexpressed diseased tissues cells, providing a feature active targeting disease site without addition specific ligands to nanocarrier. For this reason, albumin, characterized by extended serum half-life around 19 days, has potential promoting extension targeted delivery drugs. Therefore, article focuses on importance as nanodrug hydrophobic taking advantage passive well Particular attention paid breakthrough NAB-Technology, emphasis advantages Nab-Paclitaxel (Abraxane), compared solvent-based formulations Paclitaxel, i.e., CrEL-paclitaxel (Taxol) setting. role carrying anticancer compounds depicted, particular focus albumin-based that are currently undergoing trials. The sheds light power endogenous substance, such drug system, signifies vehicle performance biological systems, highlights possible future trends use system.

Language: Английский

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Stimuli‐responsive nanotherapeutics for precision drug delivery and cancer therapy

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2018, Volume and Issue: 11(1)

Published: May 4, 2018

Cancer remains one of the world's leading causes death. However, most conventional chemotherapeutic drugs only show a narrow therapeutic window in patients because their inability to discriminate cancer cells from healthy cells. Nanoparticle-based therapeutics (termed nanotherapeutics) have emerged as potential solutions mitigate many obstacles posed by these free drugs. Deep insights into knowledge tumor microenvironment and materials science make it possible construct nanotherapeutics that are able release cargoes response variety internal stimuli external triggers. Therefore, such highly sophisticated nanosystems could help impede premature toxic blood circulation or tissues, thus enhancing safety profiles encapsulated In this context, review offers comprehensive overview several specific stimuli, including (e.g., pH, temperature, enzyme, redox, H2 O2 ) magnetic, photo, ultrasound). We envision applications smart can benefit provide good chance for clinical translation nanoparticle formulas. This article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease Diagnostic Tools Nanodevices vitro Nanoparticle-Based Sensing.

Language: Английский

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Biodegradable polymers and constructs: A novel approach in drug delivery

European Polymer Journal, Journal Year: 2019, Volume and Issue: 120, P. 109191 - 109191

Published: Aug. 16, 2019

Language: Английский

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Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics

Science Advances, Journal Year: 2019, Volume and Issue: 5(9)

Published: Sept. 6, 2019

Complexation of cyanine dye with albumin produces efficient NIR-II fluorophore improving the resolution in vivo bioimaging.

Language: Английский

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Recent Trends of the Bio-Inspired Nanoparticles in Cancer Theranostics

Frontiers in Pharmacology, Journal Year: 2019, Volume and Issue: 10

Published: Oct. 25, 2019

In recent years, various nanomaterials have emerged as an exciting tool in cancer theranostics applications due to their multifunctional property and intrinsic molecular aiding effective diagnosis, imaging, successful therapy. However, chemically synthesized nanoparticles several issues related the cost, toxicity effectiveness. this context, bio-inspired (NPs) held edges over conventionally low easy synthesis toxicity. present review article, a detailed overview of has been provided. This includes examples liposomes, lipid nanoparticles, protein inorganic viral nanoparticles. Finally, challenges future scopes these NPs therapy diagnostics are highlighted.

Language: Английский

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Structural and Biochemical Features of Human Serum Albumin Essential for Eukaryotic Cell Culture

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(16), P. 8411 - 8411

Published: Aug. 5, 2021

Serum albumin physically interacts with fatty acids, small molecules, metal ions, and several other proteins. Binding a plethora of bioactive substances makes it critical transport molecule. Albumin also scavenges the reactive oxygen species that are harmful to cell survival. These properties make an excellent choice promote growth maintain variety eukaryotic cells under in vitro culture environment. Furthermore, purified recombinant human serum is mostly free from impurities modifications, providing perfect as additive tissue media while avoiding any regulatory constraints. This review discusses key features implicated survival conditions.

Language: Английский

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Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities

ACS Omega, Journal Year: 2023, Volume and Issue: 8(16), P. 14290 - 14320

Published: April 10, 2023

Cancer is ranked as the second leading cause of death globally. Traditional cancer therapies including chemotherapy are flawed, with off-target and on-target toxicities on normal cells, requiring newer strategies to improve cell selective targeting. The application nanomaterial has been extensively studied explored chemical biology tools in theranostics. It shows greater applications toward stability, biocompatibility, increased permeability, resulting precise targeting, mitigating shortcomings traditional therapies. nanoplatform offers an exciting opportunity gain targeting multifunctionality. advent nanotechnology, particular development smart nanomaterials, transformed diagnosis treatment. large surface area nanoparticles enough encapsulate many molecules ability functionalize various biosubstrates such DNA, RNA, aptamers, antibodies, which helps theranostic action. Comparatively, biologically derived nanomaterials perceive advantages over produced by conventional methods terms economy, ease production, reduced toxicity. present review summarizes techniques theranostics emphasizes (such organic (NPs), inorganic NPs, carbon-based NPs). We also critically discussed challenges impeding their translation treatment diagnostic applications. This concludes that use could significantly will facilitate new dimensions for tumor detection therapy.

Language: Английский

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