Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

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Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review

Molecules, Journal Year: 2024, Volume and Issue: 29(12), P. 2812 - 2812

Published: June 13, 2024

Tau protein is a microtubule-associated that widely distributed in the central nervous system and maintains regulates neuronal morphology function. aggregates abnormally forms neurofibrillary tangles neurodegenerative diseases, disrupting structure function of neurons leading to death, which triggers initiation progression neurological disorders. The aggregation tau diseases associated with post-translational modifications, may affect hydrophilicity, spatial conformation, stability protein, promoting formation tangles. Therefore, studying role mechanism aberrant important for understanding finding therapeutic approaches. This review describes possible mechanisms by promotes modifications influencing factors, current status drug discovery development related contribute new approaches alleviate or treat diseases.

Language: Английский

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Amyloid-β-targeting immunotherapies for Alzheimer's disease

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 346 - 365

Published: Sept. 18, 2024

Language: Английский

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Breaking Barriers in Huntington’s Disease Therapy: Focused Ultrasound for Targeted Drug Delivery

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(1)

Published: Jan. 3, 2025

Abstract Huntington’s disease (HD) is a progressive neurodegenerative resulting from mutation in the huntingtin (HTT) gene and characterized by motor dysfunction, cognitive decline, psychiatric disturbances. Currently, no disease-modifying treatments are available. Recent research has developed therapeutic agents that may have potential to directly target pathology, such as silencing or clearing mutant protein. However, these limited their inability cross blood-brain barrier (BBB), preventing optimal effects. Although various techniques been explored overcome BBB, focused ultrasound (FUS) emerged promising non-invasive modality offering for targeted intervention diseases, including HD. Preclinical studies demonstrated safety efficacy of FUS delivering agents, siRNAs AAV vector-based therapy, significant reductions HTT expression improvements function HD mouse models. Furthermore, profile FUS-induced BBB opening established clinical trials on human patients diseases other than HD, showing adverse effects brain structure function. This review provides comprehensive overview current state connects existing evidence with its promise establishing therapies Graphical

Language: Английский

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Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(18), P. 6149 - 6159

Published: Jan. 1, 2023

Controlled drug release of nanoparticles was achieved by irreversibly disrupting polymer micelles through high-intensity focused ultrasound (HIFU) induction. An ultrasound-responsive block copolymer synthesized, comprising an end-functional Eosin Y fluorophore, 2-tetrahydropyranyl acrylate (THPA), and mannose (MAN). The then self-assembled to produce micelles. chemotherapy dasatinib (DAS) the sonodynamic therapy agent methylene blue (MB) were encapsulated self-assembly copolymer. This targeted nanoparticle enables while triggering disassembly for controlled release. ultrasound-mediated, non-invasive strategy provides external spatiotemporal control tumour treatment.

Language: Английский

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Co-Culture Models: Key Players in In Vitro Neurotoxicity, Neurodegeneration and BBB Modeling Studies

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 626 - 626

Published: March 12, 2024

The biological barriers existing in the human body separate blood circulation from interstitial fluid tissues. blood-brain barrier (BBB) isolates central nervous system bloodstream, presenting a dual role: protection of brain against potentially toxic/harmful substances coming blood, while providing nutrients to and removing metabolites. In terms architectural features, presence junctional proteins (that restrict paracellular transport) existence efflux transporters at BBB are two major vivo characteristics that increase difficulty creating an ideal vitro model for drug permeability studies neurotoxicity assessments. purpose this work is provide up-to-date literature review on current models used studies, focusing characteristics, advantages, disadvantages both primary cultures immortalized cell lines. An accurate analysis more recent emerging techniques implemented optimize also provided, based need recreating as closely possible microenvironment. fact, acceptance phenotype much than endothelial cells monolayer has led shift single-cell multicellular models. Thus, co-culture have narrowed gap between faithfully phenotype. This relevant assays, related neurodegenerative diseases. Several with these purposes will be presented discussed.

Language: Английский

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A patient-derived amyotrophic lateral sclerosis blood-brain barrier model for focused ultrasound-mediated anti-TDP-43 antibody delivery

Fluids and Barriers of the CNS, Journal Year: 2024, Volume and Issue: 21(1)

Published: Aug. 13, 2024

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder with minimally effective treatment options. An important hurdle in ALS drug development the non-invasive therapeutic access to motor cortex currently limited by presence of blood-brain barrier (BBB). Focused ultrasound and microbubble (FUS

Language: Английский

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Human mini-blood–brain barrier models for biomedical neuroscience research: a review

Biomaterials Research, Journal Year: 2022, Volume and Issue: 26(1)

Published: Sept. 30, 2022

The human blood-brain barrier (BBB) is a unique multicellular structure that in critical demand for fundamental neuroscience studies and therapeutic evaluation. Despite substantial achievements creating vitro BBB platforms, challenges generating specifics of physiopathological relevance are viewed as impediments to the establishment models. In this review, we provide insight into development deployment models allow investigation physiology pathology neurological avenues. First, highlight components, including cell sources, biomaterial glue collections, engineering techniques reconstruct miniaturized BBB. Second, describe recent breakthroughs mini-BBBs investigating biological mechanisms neurology. Finally, discuss application medical approaches. This review provides strategies understanding diseases, validation model drug discovery, potential approach personalized medicine.

Language: Английский

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Patient-Derived Blood-Brain Barrier Model for Screening Copper Bis(thiosemicarbazone) Complexes as Potential Therapeutics in Alzheimer’s Disease

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(7), P. 1432 - 1455

Published: March 13, 2024

Alzheimer's disease (AD) is the most prevalent cause of dementia characterized by a progressive cognitive decline. Addressing neuroinflammation represents promising therapeutic avenue to treat AD; however, development effective antineuroinflammatory compounds often hindered their limited blood-brain barrier (BBB) permeability. Consequently, there an urgent need for accurate, preclinical AD patient-specific BBB models facilitate early identification immunomodulatory drugs capable efficiently crossing human BBB. This study presents unique approach drug permeability screening as it utilizes familial patient-derived induced brain endothelial-like cell (iBEC)-based model, which exhibits increased relevance and serves improved assessment tool when compared traditionally employed in vitro models. To demonstrate its utility small molecule candidate platform, we investigated effects diacetylbis(N(4)-methylthiosemicarbazonato)copper(II) (CuII(atsm)) library metal bis(thiosemicarbazone) complexes─a class exhibiting potential neurodegenerative disorders. By evaluating toxicity, cellular accumulation, those iBEC, have identified 3,4-hexanedione bis(N(4)-methylthiosemicarbazonato)copper(II) (CuII(dtsm)) with good transport across Furthermore, developed multiplex where iBEC were combined immune modulators TNFα IFNγ establish model representing characteristic neuroinflammatory phenotype at patient's Here, observed that treatment CuII(dtsm) not only reduced expression proinflammatory cytokine genes but also reversed detrimental on integrity function monolayer. suggests novel pathway through copper complexes may exert neurotherapeutic mitigating related impairment. Together, presented provides easily scalable platform candidates. Its translational makes valuable advancing metal-based aimed modulating AD.

Language: Английский

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New Insights into Alzheimer’s Disease: Novel Pathogenesis, Drug Target and Delivery

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1133 - 1133

Published: April 3, 2023

Alzheimer’s disease (AD), the most common type of dementia, is characterized by senile plaques composed amyloid β protein (Aβ) and neurofilament tangles derived from hyperphosphorylation tau protein. However, developed medicines targeting Aβ have not obtained ideal clinical efficacy, which raises a challenge to hypothesis that AD cascade-induced. A critical problem pathogenesis endogenous factor induces aggregation phosphorylation. Recently, age-associated formaldehyde has been suggested be direct trigger for Aβ- tau-related pathology. Another key issue whether or drugs are successfully delivered damaged neurons. Both blood–brain barrier (BBB) extracellular space (ECS) barriers drug delivery. Unexpectedly, Aβ-related SP deposition in ECS slows down stops interstitial fluid drainage AD, reason delivery failure. Here, we propose new perspectives on direction development delivery: (1) aging-related assembly hyperphosphorylation, target therapy formaldehyde; (2) nano-packaging physical may promising strategy increasing BBB permeability accelerating drainage.

Language: Английский

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