Evolution of fatty acid taste in drosophilids DOI Creative Commons
Manali Dey, Elizabeth Brown,

Sandhya Charlu

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(10), P. 113297 - 113297

Published: Oct. 1, 2023

Comparative studies of related but ecologically distinct species can reveal how the nervous system evolves to drive behaviors that are particularly suited certain environments. Drosophila melanogaster is a generalist feeds and oviposits on most overripe fruits. A sibling species, D. sechellia, an obligate specialist Morinda citrifolia (noni) fruit, which rich in fatty acids (FAs). To understand evolution noni taste preference, we characterized behavioral cellular responses noni-associated FAs three drosophilids. We find mixtures sugar evoke strong aversion not sechellia. Surveys sensory FA- species-specific differences at least two mechanisms—bitter neuron activation sweet inhibition–that correlate with shifts preference. Chemoreceptor mutant analysis predicts multiple genetic changes account for gustatory preference

Language: Английский

A molecular mechanism for high salt taste in Drosophila DOI Creative Commons
Sasha A.T. McDowell, Molly Stanley, Michael D. Gordon

et al.

Current Biology, Journal Year: 2022, Volume and Issue: 32(14), P. 3070 - 3081.e5

Published: June 29, 2022

Language: Английский

Citations

42
Molecular sensors in the taste system of Drosophila DOI
Bhanu Shrestha, Youngseok Lee

Genes & Genomics, Journal Year: 2023, Volume and Issue: 45(6), P. 693 - 707

Published: Feb. 24, 2023

Language: Английский

Citations

23
Molecular and Cellular Mechanisms of Salt Taste DOI
Akiyuki Taruno, Michael D. Gordon

Annual Review of Physiology, Journal Year: 2022, Volume and Issue: 85(1), P. 25 - 45

Published: Nov. 5, 2022

Salt taste, the taste of sodium chloride (NaCl), is mechanistically one most complex and puzzling among basic tastes. Sodium has essential functions in body but causes harm excess. Thus, animals use salt to ingest right amount salt, which fluctuates by physiological needs: typically, attraction low concentrations rejection high salt. This concentration-valence relationship universally observed terrestrial animals, research revealed peripheral codes for NaCl involving multiple pathways opposing valence. Sodium-dependent -independent mediate aversion NaCl, respectively. Gustatory sensors cells that transduce have been uncovered, along with downstream signal transduction neurotransmission mechanisms. However, much remains unknown. article reviews classical recent advances our understanding molecular cellular mechanisms underlying mammals insects discusses perspectives on human taste.

Language: Английский

Citations

36
Taste coding of heavy metal ion-induced avoidance in Drosophila DOI Creative Commons
Xiaonan Li, Yuanjie Sun, Shan Gao

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(5), P. 106607 - 106607

Published: April 7, 2023

Increasing pollution of heavy metals poses great risks to animals globally. Their survival likely relies on an ability detect and avoid harmful metal ions (HMIs). Currently, little is known about the neural mechanisms HMI detection. Here, we show that Drosophila related species Drosophilidae actively toxic HMIs at micromolar concentrations. The high sensitivity biologically relevant. Particularly, their cadmium as most bitter substance, denatonium. Detection in food requires Gr66a+ gustatory neurons but independent bitter-taste receptors. In these neurons, ionotropic receptors IR76b, IR25a, IR7a are required for perception metals. Furthermore, IR47a mediates activation a distinct group non-Gr66a+ elicited by HMIs. Together, our findings reveal surprising taste quality represented noxious ions.

Language: Английский

Citations

20
A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster DOI Creative Commons
Jiun Sang, Subash Dhakal, Bhanu Shrestha

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Dec. 27, 2023

Salt (NaCl), is an essential nutrient for survival, while excessive salt can be detrimental. In the fruit fly, Drosophila melanogaster , internal taste organs in pharynx are critical gatekeepers impacting decision to accept or reject a food. Currently, our understanding of mechanism through which pharyngeal gustatory receptor neurons (GRNs) sense high rudimentary. Here, we found that member ionotropic family, Ir60b expressed exclusively pair GRNs activated by salt. Using two-way choice assay (DrosoX) measure ingestion volume, demonstrate IR60b and two co-receptors IR25a IR76b required prevent consumption. Mutants lacking external but retaining exhibit much higher avoidance than flies with all missing three IRs. Our findings highlight vital role IRs GRN control

Language: Английский

Citations

17
Avoiding alkaline taste through ionotropic receptors DOI Creative Commons
Prakash Pandey,

Bhanu Shrestha,

Youngseok Lee

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 110087 - 110087

Published: May 23, 2024

Taste organs contain distinct gustatory receptors that help organisms differentiate between nourishing and potentially harmful foods. The detection of high pH levels plays a crucial role in food selection, but the specific responsible for perceiving elevated foods have remained unknown. By using

Language: Английский

Citations

7
Alkaline taste sensation through the alkaliphile chloride channel in Drosophila DOI
Ting‐Wei Mi, J. Mack,

Wyatt Koolmees

et al.

Nature Metabolism, Journal Year: 2023, Volume and Issue: 5(3), P. 466 - 480

Published: March 20, 2023

Language: Английский

Citations

16
The taste of vitamin C in Drosophila DOI
Bhanu Shrestha, Binod Aryal, Youngseok Lee

et al.

EMBO Reports, Journal Year: 2023, Volume and Issue: 24(6)

Published: April 28, 2023

Language: Английский

Citations

16
Tastant-receptor interactions: insights from the fruit fly DOI

Christian Arntsen,

Jacqueline Guillemin,

Kayla Audette

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 11, 2024

Across species, taste provides important chemical information about potential food sources and the surrounding environment. As details chemicals receptors responsible for gustation are discovered, a complex view of system is emerging with significant contributions from research using fruit fly, Drosophila melanogaster , as model organism. In this brief review, we summarize recent advances in their relevance to more broadly. Our goal highlight molecular mechanisms underlying first step gustatory circuits: ligand-receptor interactions primary cells. After an introduction how it encodes canonical modalities sweet, bitter, salty, describe insights into nature carboxylic acid amino detection context sour umami taste, respectively. analysis extends non-canonical including metals, fatty acids, bacterial components, highlights unexpected signaling pathways that have recently been identified Comparing intricate cellular underpinnings ligands detected vivo flies reveals both specific promiscuous receptor selectivity encoding. Throughout compare contextualize these findings mammalian not only emphasize conservation chemosensory systems, but demonstrate power organism elucidating neurobiology feeding.

Language: Английский

Citations

5
Taste cells expressing Ionotropic Receptor 94e reciprocally impact feeding and egg laying in Drosophila DOI Creative Commons

Jacqueline Guillemin,

Jinfang Li,

Viktoriya Li

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(8), P. 114625 - 114625

Published: Aug. 1, 2024

Chemosensory cells across the body of Drosophila melanogaster evaluate environment to prioritize certain behaviors. Previous mapping gustatory receptor neurons (GRNs) on fly labellum identified a set in L-type sensilla that express Ionotropic Receptor 94e (IR94e), but impact IR94e GRNs behavior remains unclear. We used optogenetics and chemogenetics activate found they drive mild feeding suppression enhance egg laying. In vivo calcium imaging revealed respond strongly amino acids, including glutamate, plus co-receptors IR25a IR76b are required for acid detection. Furthermore, mutants show behavioral changes solutions containing increased consumption decreased Overall, our results suggest discourage encourage laying as part an important switch response chemical cues.

Language: Английский

Citations

5