A shift in the mechanisms controlling hippocampal engram formation during brain maturation

Science, Journal Year: 2023, Volume and Issue: 380(6644), P. 543 - 551

Published: May 4, 2023

The ability to form precise, episodic memories develops with age, young children only able gist-like that lack precision. cellular and molecular events in the developing hippocampus underlie emergence of episodic-like memory are unclear. In mice, absence a competitive neuronal engram allocation process immature precluded formation sparse engrams precise until fourth postnatal week, when inhibitory circuits mature. This age-dependent shift precision involved functional maturation parvalbumin-expressing interneurons subfield CA1 through assembly extracellular perineuronal nets, which is necessary sufficient for onset allocation, formation,

Language: Английский

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Network state transitions during cortical development

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(8), P. 535 - 552

Published: May 23, 2024

Language: Английский

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Remapping revisited: how the hippocampus represents different spaces

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(6), P. 428 - 448

Published: May 7, 2024

Language: Английский

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Principles of GABAergic signaling in developing cortical network dynamics

Cell Reports, Journal Year: 2022, Volume and Issue: 38(13), P. 110568 - 110568

Published: March 1, 2022

GABAergic signaling provides inhibitory stabilization and spatiotemporally coordinates the firing of recurrently connected excitatory neurons in mature cortical circuits. Inhibition thus enables self-generated neuronal activity patterns that underlie various aspects sensation cognition. In this review, we aim to provide a conceptual framework describing how when GABA-releasing interneurons acquire their network functions during development. Focusing on developing visual neocortex hippocampus mice rats vivo, hypothesize at onset patterned activity, glutamatergic are stable by themselves is not yet functional. We review important milestones development illustrate cell-type-specific strengthening synaptic inhibition toward eye opening shapes dynamics allows cortex progressively disengage from extra-cortical drive. translate human discuss clinical implications for treatment neonatal seizures.

Language: Английский

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Extrinsic control of the early postnatal CA1 hippocampal circuits

Neuron, Journal Year: 2023, Volume and Issue: 111(6), P. 888 - 902.e8

Published: Jan. 5, 2023

Language: Английский

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A developmental increase of inhibition promotes the emergence of hippocampal ripples

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 25, 2024

Abstract Sharp wave-ripples (SPW-Rs) are a hippocampal network phenomenon critical for memory consolidation and planning. SPW-Rs have been extensively studied in the adult brain, yet their developmental trajectory is poorly understood. While SPWs recorded rodents shortly after birth, time point mechanisms of ripple emergence still unclear. Here, we combine vivo electrophysiology with optogenetics chemogenetics 4 to 12-day-old mice address this knowledge gap. We show that ripples robustly detected induced by light stimulation channelrhodopsin-2-transfected CA1 pyramidal neurons only from postnatal day 10 onwards. Leveraging spiking neural model, mechanistically link maturation inhibition emergence. corroborate these findings reducing rate upon chemogenetic silencing interneurons. Finally, early elicit more robust prefrontal cortex response than lacking ripples. Thus, development promotes

Language: Английский

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Multiphoton imaging of hippocampal neural circuits: techniques and biological insights into region-, cell-type-, and pathway-specific functions

Neurophotonics, Journal Year: 2024, Volume and Issue: 11(03)

Published: March 8, 2024

SignificanceThe function of the hippocampus in behavior and cognition has long been studied primarily through electrophysiological recordings from freely moving rodents. However, application optical recording methods, particularly multiphoton fluorescence microscopy, last decade or two dramatically advanced our understanding hippocampal function. This article provides a comprehensive overview techniques biological findings obtained imaging neural circuits.AimThis review aims to summarize discuss recent technical advances circuits accumulated knowledge gained this technology.ApproachFirst, we provide brief various its advantages, drawbacks, associated key innovations practices. Then, large body by region (CA1 dentate gyrus), cell type (pyramidal neurons, inhibitory interneurons, glial cells), cellular compartment (dendrite axon).ResultsMultiphoton is performed under head-fixed conditions can reveal detailed mechanisms circuit operation owing high spatial resolution specificity. As lies deep below cortex, requires elaborate methods. These include cannula implantation, microendoscopy, use long-wavelength light sources. Although many studies have focused on dorsal CA1 pyramidal cells, other local inter-areal circuitry elements also helped more picture information processing circuits. Imaging mouse models Alzheimer's disease brain disorders such as autism spectrum disorder contributed greatly their pathophysiology.ConclusionsMultiphoton revealed much regarding region-, cell-type-, pathway-specific dysfunction health disease. Future technological will allow further illustration operating principle via large-scale, high-resolution, multimodal, minimally invasive imaging.

Language: Английский

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The evolving neurobiology of early-life stress

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Development of Prefrontal Circuits and Cognitive Abilities

Cold Spring Harbor Perspectives in Biology, Journal Year: 2024, Volume and Issue: 16(10), P. a041502 - a041502

Published: May 1, 2024

The prefrontal cortex is considered as the site of multifaceted higher-order cognitive abilities. These abilities emerge late in life long after full sensorimotor maturation, line with protracted development circuits that has been identified on molecular, structural, and functional levels. Only recently, a result impressive methodological progress last several decades, mechanisms clinical implications have begun to be elucidated, yet major knowledge gaps still persist. Here, we provide an overview how develop enable processing at adulthood. First, review recent insights into circuit assembly, focus contribution early electrical activity. Second, highlight reorganization during adolescence. Finally, link plasticity specific developmental time windows mental health disorders discuss potential approaches for therapeutic interventions.

Language: Английский

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cFOS as a biomarker of activity maturation in the hippocampal formation

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: July 13, 2023

We explored the potential for cFOS expression as a marker of functional development “resting-state” waking activity in extended network hippocampus and entorhinal cortex. examined sleeping awake mice at (P)ostnatal days 5, 9, 13, 17 well adulthood. find that is state-dependent even 5 old, with reliable staining occurring only mice. Even during waking, was rare weak P5. The septal nuclei, cortex layer (L)2, anterodorsal thalamus were exceptional they had robust P5 similar to or greater than Significant also observed dentate gyrus, L6, postsubiculum L4-6, ventral subiculum, supramammillary nucleus, posterior hypothalamic nucleus. these regions grew stronger age, new added progressively P9 P13 by which point overall pattern many qualitatively adult. Six regions—CA1, dorsal L2-3, reuniens perirhinal postrhinal cortices—were very late developing, mostly achieving adult levels after P17. Our findings support number developmental principles. First, early spontaneous patterns induced muscle twitches sleep do not induce hippocampal network. Second, follows progressive activation along trisynaptic circuit, rather birth date cellular maturation. Third, we reveal components egocentric head-direction theta-rhythm circuits earliest active forebrain. results suggest may provide sensitive biomarker formation development, particularly regard attainment normal state synchronizing rhythms such theta gamma.

Language: Английский

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