bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 31, 2023
Neuronal hyperexcitability is a hallmark of seizures. It has been recently shown in rodent models seizures that microglia, the brain's resident immune cells, can respond to and modulate neuronal excitability. However, how human microglia interacts with neurons regulate mediated by epilepsy-causing genetic mutation found patients remains unknown. The
Language: Английский
Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(3), P. 181 - 194
Published: Jan. 21, 2024
Language: Английский
Citations
42
Neuron, Journal Year: 2024, Volume and Issue: 112(18), P. 3106 - 3125.e8
Published: July 25, 2024
Microglia are crucial for maintaining brain health and neuron function. Here, we report that microglia establish connections with neurons using tunneling nanotubes (TNTs) in both physiological pathological conditions. These TNTs facilitate the rapid exchange of organelles, vesicles, proteins. In neurodegenerative diseases like Parkinson's Alzheimer's disease, toxic aggregates alpha-synuclein (α-syn) tau accumulate within neurons. Our research demonstrates use to extract from these aggregates, restoring neuronal health. Additionally, share their healthy mitochondria burdened neurons, reducing oxidative stress normalizing gene expression. Disrupting mitochondrial function antimycin A before TNT formation eliminates this neuroprotection. Moreover, co-culturing promoting rescues suppressed activity caused by α-syn or aggregates. Notably, TNT-mediated aggregate transfer is compromised carrying Lrrk22(Gly2019Ser) Trem2(T66M) (R47H) mutations, suggesting a role pathology variants diseases.
Language: Английский
Citations
33
Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(17), P. 3042 - 3060
Published: March 28, 2023
Microglia, the resident immune cells of CNS, sense activity neurons and regulate physiological brain functions. They have been implicated in pathology diseases associated with alterations neural excitability plasticity. However, experimental therapeutic approaches that modulate microglia function a region-specific manner not established. In this study, we tested for effects repetitive transcranial magnetic stimulation (rTMS), clinically used noninvasive technique, on microglia-mediated synaptic plasticity; 10 Hz electromagnetic triggered release plasticity-promoting cytokines from mouse organotypic tissue cultures both sexes, while no significant changes microglial morphology or dynamics were observed. Indeed, substitution tumor necrosis factor α (TNFα) interleukin 6 (IL6) preserved plasticity induced by absence microglia. Consistent these findings,
Language: Английский
Citations
33
eLife, Journal Year: 2023, Volume and Issue: 12
Published: Feb. 7, 2023
Microglia, the resident immune cells of brain, play a complex role in health and disease. They actively survey brain parenchyma by physically interacting with other structurally shaping brain. Yet, mechanisms underlying microglial motility significance for synapse stability, especially hippocampus during adulthood, remain widely unresolved. Here, we investigated effect neuronal activity on implications formation survival dendritic spines hippocampal CA1 neurons vivo. We used repetitive two-photon vivo imaging awake anesthetized mice to simultaneously study microglia their interaction spines. found that CA3 input is sufficient modulate process motility. Simultaneously, more emerged after compared imaging. Interestingly, rate contacts individual dendrites was associated removal, emergence These results suggest might sense via neurotransmitter release participate synaptic rewiring neural network adulthood. Further, this has profound relevance learning memory processes.
Language: Английский
Citations
32
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 558 - 558
Published: May 30, 2024
Mood disorders and substance use disorder (SUD) are of immense medical social concern. Although significant progress on neuronal involvement in mood reward circuitries has been achieved, it is only relatively recently that the role glia these attracted attention. Detailed understanding glial functions devastating diseases could offer novel interventions. Here, following a brief review involved regulation perception, specific contributions neurotrophic factors, neuroinflammation, gut microbiota to highlighted. In this context, cells (e.g., microglia, astroglia, oligodendrocytes, synantocytes) phenotypic manifestation or SUD emphasized. addition, knowledge potential development therapeutics touched upon.
Language: Английский
Citations
13
Nature Neuroscience, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 11, 2024
Language: Английский
Citations
8
Journal of Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 154(3), P. 127 - 138
Published: Jan. 9, 2024
More than half of methamphetamine (METH) users present with cognitive impairment, making it difficult for them to reintegrate into society. However, the mechanisms METH-induced impairment remain unclear. METH causes neuronal hyperactivation in nucleus accumbens (NAc) by aberrantly releasing dopamine, which triggers dependence. In this study, clarify involvement NAc mice were locally microinjected (mice (NAc)) and investigated their phenotype. Mice exhibited dysfunction behavioral analyses decreased long-term potentiation hippocampus, activation confirmed expression FosB, a activity marker. hippocampus (NAc), activated microglia, but not astroglia, upregulated microglia-related genes, Il1b C1qa observed. Finally, administration minocycline, tetracycline antibiotic suppressive effect on microglial activation, ameliorated synaptic suppressing increased hippocampus. conclusion, injection elicited facilitating immune mice. This study suggests that immunological intervention could be therapeutic strategy addiction-related disturbances.
Language: Английский
Citations
4
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: June 7, 2024
There is a well-established link between physical activity and brain health. As such, the effectiveness of exercise as therapeutic strategy has been explored in variety neurological contexts. To determine extent to which could be most beneficial under different circumstances, studies are needed uncover underlying mechanisms behind benefits activity. Interest grown understanding how can regulate microglia, resident immune cells central nervous system. Microglia key mediators neuroinflammatory processes play role maintaining homeostasis healthy pathological settings. Here, we explore evidence suggesting that potential microglia various animal models. We emphasize areas where future research contribute uncovering engaging exercise.
Language: Английский
Citations
4
Developmental Neurobiology, Journal Year: 2020, Volume and Issue: 80(7-8), P. 277 - 301
Published: July 1, 2020
Abstract Axons in the adult mammalian central nervous system (CNS) fail to regenerate inside out due intrinsic and extrinsic neuronal determinants. During CNS development, axon growth, synapse formation, function are tightly regulated processes allowing immature neurons effectively grow an axon, navigate toward target areas, form synaptic contacts become part of information processing networks that control behavior adulthood. Not only able precisely expression a plethora genes necessary for extension pathfinding, formation function, but also non‐neuronal cells such as astrocytes microglia actively participate sculpting through refinement, consolidation, elimination contacts. Recent evidence indicates balancing act between regeneration may be crucial rebuilding functional circuits after trauma disease Here, we review role classical new determinants context injury, disease. Moreover, discuss strategies targeting cell behaviors, either alone or combination, promote circuit
Language: Английский
Citations
29
Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)
Published: Jan. 27, 2025
Language: Английский
Citations
0