General and Comparative Endocrinology, Journal Year: 2023, Volume and Issue: 347, P. 114421 - 114421
Published: Dec. 9, 2023
Language: Английский
Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(10)
Published: March 21, 2024
Elevated bone resorption and diminished formation have been recognized as the primary features of glucocorticoid-associated skeletal disorders. However, direct effects excess glucocorticoids on turnover remains unclear. Here, we explored outcomes exogenous glucocorticoid treatment loss delayed fracture healing in mice found that reduced was a dominant feature, resulting net mass. The effect osteogenic differentiation not inhibitory; instead, they cooperated with macrophages to facilitate osteogenesis. Impaired local nutrient status, notably, obstructed fatty acid transportation, key factor contributing glucocorticoid-induced impairment vivo. Furthermore, oxidation fueled ability glucocorticoid-liganded receptors enter nucleus then promoted expression Bmp2, cytokine facilitates Metabolic reprogramming by localized delivery partly rescued pathology restoring healthier immune-metabolic milieu. These data provide insights into multifactorial metabolic mechanisms which generate disorders, thus suggesting possible therapeutic avenues.
Language: Английский
Citations
11
Nature Aging, Journal Year: 2024, Volume and Issue: 4(10), P. 1354 - 1371
Published: Oct. 8, 2024
Language: Английский
Citations
8
Learning and Instruction, Journal Year: 2024, Volume and Issue: 92, P. 101939 - 101939
Published: May 22, 2024
Language: Английский
Citations
6
Journal of Animal Ecology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
Challenging events in the environment that are both predictable (e.g. seasonal patterns breeding activities) and unpredictable predator encounter) known to induce a glucocorticoid response facilitates metabolic requirements during challenge. Given its role mobilizing energy, levels can influence nutritional ecology of an individual by shifting dietary intake or retention patterns, but this relationship has not been tested free-ranging vertebrates. Using tropical lizard species (Psammophilus dorsalis) as model system, we whether elemental composition excretion (faecal samples) varies with stress-induced corticosterone males females across different seasons. From lizards wild, measured glucose blood determined diet from gut-flushing. Elemental was analysing carbon nitrogen content identified prey Orders caught wild. We also collected faecal samples estimated their composition. found varied seasons, lowest season for females. Despite high variation responsiveness, did shift diets maintained carbon:nitrogen ratio 4.56. did, however, find negative correlation between composition, suggesting selective individuals have higher responsiveness. This study highlights interplay responsiveness ecology, challenging existing links literature illustrating how animals, such lizards, adjust intakes potential strategy modulate natural physiological ecological challenges.
Language: Английский
Citations
0
BMC Veterinary Research, Journal Year: 2025, Volume and Issue: 21(1)
Published: April 14, 2025
Abstract Background Extensive animal production systems, such as reindeer husbandry may represent a system to further study the context dependence of stress responses and potential implications for welfare research on food has so far primarily focused animals in intensive systems while from extensive reindeer, are yet underrepresented. We investigated short- longer-term repeated herding, handling restraint its effect semi-domesticated adult female ( Rangifer tarandus ). also assessed seasonal differences additional stressor calf removal using serum concentrations glucocorticoids (cortisol, cortisone corticosterone), their precursors (11-desoxcortisol, 17-α-hydroxyprogesterone deoxycorticosterone) catecholamine metabolites (metanephrine normetanephrine) combination with immunological proxy leukocyte coping capacity (LCC) rectal temperature. Additionally, we interconnections among different indices suitability indicators evaluate handling-induced where temperature, other than cortisol levels, emerged robust integrative parameter. Results Herding, handling, elicited marked seasonally short-term response higher mediator levels winter. Further, females who had removed shortly after parturition showed increased based LCC. The exposure same stressors led habituation, decreasing procedure both seasons. This outcome implies that present were able cope well manipulations this intensification not compromise welfare. Notably, traditional index body temperature correlated various encompassing HPA axis (cortisol corticosterone summer additionally 11-deoxycortisol winter), sympathetic-adrenal-medullary (metanephrine) (LCC), Conclusion Our results emphasise (rectal) parameter our study. findings add foundation evaluating available individual environmental contexts contribute improved management practices aimed at reducing enhancing
Language: Английский
Citations
0
Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: 177, P. 107474 - 107474
Published: April 25, 2025
Language: Английский
Citations
0
Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 227(14)
Published: July 1, 2024
ABSTRACT Glucocorticoid (GC) hormones have traditionally been interpreted as indicators of stress, but the extent to which they provide information on physiological state remains debated. GCs are metabolic that amongst other functions ensure increasing fuel (i.e. glucose) supply face fluctuating energetic demands, a role often overlooked by ecological studies investigating consequences GC variation. Furthermore, because energy budget is limited, in natural contexts where multiple stimuli coexist, organisms' ability respond physiologically may be constrained when triggers responses overlap time. Using free-living spotless starling (Sturnus unicolor) chicks, we experimentally tested whether two different nature known trigger or response, respectively, cause comparable increase plasma and glucose. We further response patterns differed both occurred consecutively. found experimental treatments caused increases glucose similar magnitude, suggesting variables fluctuate along with variation expenditure, independently trigger. Exposure occurring subsequently did not difference compared exposure single stimulus, limited capacity an additional stimulus during ongoing acute response. Lastly, positive significant correlation between after treatments. Our results add research expenditure variation, providing evidence association metabolism.
Language: Английский
Citations
2
American Journal of Human Biology, Journal Year: 2024, Volume and Issue: 36(10)
Published: July 21, 2024
Abstract Pubertal research has primarily focused on hypothalamic–pituitary–gonadal axis (HPG) regulation of puberty, though the hypothalamic–pituitary–adrenal (HPA) is increasingly considered critical. Heightened HPA function proxied by increasing cortisol levels may play a role in accelerated pubertal timing. However, extent to which varies across ages and its relation changes linear growth are less well substantiated. We explored relationships between age, growth, adiposity, C‐peptide (proxy for insulin), we tested whether higher associated with earlier at menarche peak height velocity. utilize longitudinal data ( n = 777 urine samples) from Qom females 7–14 46) test our pre‐registered analysis using Bayesian mixed effects models joint modeling techniques. find limited evidence supporting overarching hypothesis that upregulation maturation or some upregulation, as cortisol, be more clearly related differences relative early‐mid measured height‐for‐age z ‐scores. Transdisciplinary perspectives including assumption stressors acting via accelerate development, discussed.
Language: Английский
Citations
2
Biology Letters, Journal Year: 2024, Volume and Issue: 20(11)
Published: Nov. 1, 2024
The accident that occurred at the Chornobyl nuclear power plant (Ukraine, 1986) contaminated a large extension of territory after deposition radioactive material. It is still under debate whether chronic exposure to radiation levels currently present in area has long-term effects on organisms, such as decreases longevity. Here, we investigate current negatively impact age Eastern tree frog Hyla orientalis . We also explore induces changes an ageing marker, telomere length or stress hormone corticosterone. found no effect total individual absorbed (including both external and internal exposure) ( n = 197 individuals sampled 3 consecutive years). did not find any relationship between length, nor corticosterone levels. Our results suggest experienced by frogs may be high enough cause severe damage semi-aquatic vertebrates this species. This first study addressing hormones wildlife, thus future research will confirm if these can extended other taxa.
Language: Английский
Citations
2
Published: Nov. 24, 2023
Aging involves seemingly paradoxical changes in energy metabolism. Molecular damage accumulation increases cellular expenditure, yet whole-body expenditure remains stable or decreases with age. We resolve this apparent contradiction by positioning the brain as mediator and broker organismal economy. As somatic tissues accumulate over time, costly intracellular stress responses are activated, causing aging/senescent cells to secrete cytokines that convey increased demand – hypermetabolism brain. To conserve face of a shrinking budget, deploys conservation responses, which suppress low priority processes, producing fatigue, physical inactivity, blunted sensory capacities, immune alterations, endocrine “deficits”. term cascade Brain-body Energy Conservation (BEC) model aging. The BEC outlines 1) energetic cost aging, 2) how perception senescence-associated may drive phenotypic manifestations 3) principles underlying modifiability aging trajectories stressors geroscience interventions.
Language: Английский
Citations
2