Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients

Journal of Trace Elements in Medicine and Biology, Journal Year: 2022, Volume and Issue: 73, P. 127044 - 127044

Published: July 20, 2022

Language: Английский

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Global Dietary and Herbal Supplement Use during COVID-19—A Scoping Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 771 - 771

Published: Feb. 2, 2023

During the first year of COVID-19 pandemic, lack cure and intensity global spread raised a common awareness health. The aim this scoping review is to summarize dietary supplement use globally during two years pandemic. A systematic search was conducted in December 2021 following PRISMA guidelines. PubMed, ERIC, Scopus databases were searched, 956 results screened for eligibility. Fourteen cross-sectional studies from 11 countries 3 continents examined. All large population surveys investigating healthy eating COVID-19. Vitamin C, vitamin D, zinc multivitamins most widely reported, as well natural/herbal products such ginger honey. reason cited supplements strengthen immune system prevent infection These reported that populations are relying on healthcare providers, family, friends, social media learn about use. Future treatment should include more evidence

Language: Английский

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The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1345 - 1345

Published: April 29, 2024

This review aims to evaluate the efficacy of any vitamin administration(s) in preventing and managing COVID-19 and/or long-COVID. Databases were searched up May 2023 identify randomized clinical trials comparing data on effects supplementation(s) versus placebo or standard care two conditions interest. Inverse-variance random-effects meta-analyses conducted estimate pooled risk ratios (RRs) 95% confidence intervals (CIs) for all-cause mortality between supplemented non-supplemented individuals. Overall, 37 articles included: regarded long-COVID prevention 35 records management. The D contrasting. Similarly, no conclusion could be drawn multivitamins, A, B A few positive findings reported some C but results inconsistent most outcomes, excluding (RR = 0.84; CI: 0.72–0.97). Vitamin mixed aspects, including mortality, which benefits observed regular administrations only 0.67; 0.49–0.91). Despite benefits, mostly contradictory. Variety recruitment treatment protocols might explain this heterogeneity. Better-designed studies are needed clarify these vitamins’ potential against SARS-CoV-2.

Language: Английский

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The effect of adherence to high‐quality dietary pattern on COVID‐19 outcomes: A systematic review and meta‐analysis

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Nov. 11, 2022

Dietary quality and patterns may influence SARS-CoV-2 infection outcomes, but scientific data evidence to support such a role are lacking. Therefore, this meta-analysis aims elucidate the effect of prepandemic diet on risk COVID-19 hospitalization. PubMed/MEDLINE, CENTRAL, Scopus, EMBASE were systematically searched for articles published up September 1, 2022. A systematic review performed calculate each outcome's ratio (RR) 95% confidence interval (CI). Five studies including 4 023 663 individuals (3 149 784 high-quality 873 881 controls) included in present meta-analysis. The effectiveness dietary pattern against hospitalization was 28% (95% CI 19%-36%) 62% 25%-80%); respectively. Subgroup analysis based different levels showed no difference between middle high reducing infection. Interestingly, subgroup types diets revealed that plant-based 50% 30%-65%); while Mediterranean 22% 12%-31%). Adherence is associated with lower More required confirm these findings, future should determine biological mechanisms underlying association

Language: Английский

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Importance of Magnesium Status in COVID-19

Biology, Journal Year: 2023, Volume and Issue: 12(5), P. 735 - 735

Published: May 18, 2023

A large amount of published research points to the interesting concept (hypothesis) that magnesium (Mg) status may have relevance for outcome COVID-19 and Mg could be protective during COVID disease course. As an essential element, plays basic biochemical, cellular, physiological roles required cardiovascular, immunological, respiratory, neurological functions. Both low serum dietary been associated with severity outcomes, including mortality; both are also risk factors such as older age, obesity, type 2 diabetes, kidney disease, cardiovascular hypertension, asthma. In addition, populations high rates mortality hospitalization tend consume diets in modern processed foods, which generally Mg. this review, we review describe consider possible impact on showing (1) between 2.19 2.26 mg/dL intakes > 329 mg/day course (2) inhaled improve oxygenation hypoxic patients. spite promise, oral has thus far studied only combination other nutrients. deficiency is involved occurrence aggravation neuropsychiatric complications COVID-19, memory loss, cognition, loss taste smell, ataxia, confusion, dizziness, headache. Potential zinc and/or useful increasing drug therapy effectiveness or reducing adverse effect anti-COVID-19 drugs reviewed. Oral trials patients warranted.

Language: Английский

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The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review

Life Sciences, Journal Year: 2024, Volume and Issue: 342, P. 122535 - 122535

Published: Feb. 24, 2024

Emerging evidence highlights the role of COVID-19 in instigating gut dysbiosis, with repercussions on disease severity and bidirectional gut-organ communication involving lung, heart, brain, liver. This study aims to evaluate efficacy probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT) addressing dysbiosis associated COVID-19, as well their impact related clinical outcomes. We systematically review 27 studies exploring different microbiome-modulating therapies: potential interventions for COVID-19. The probiotics synbiotics investigated encompassed a spectrum eight bacterial fungal genera, namely Lactobacillus, Bifidobacterium, Streptococcus, Enterococcus, Pediococcus, Bacillus, Saccharomyces, Kluyveromyces. Noteworthy prebiotics employed these included chestnut tannin, galactooligosaccharides, fructooligosaccharides, xylooligosaccharide, resistant dextrin. majority biotics exhibited positive effects patients, manifesting symptom alleviation, inflammation reduction, notable decreases mortality rates. Five reported death rates, showing an average ranging from 0 % 11 intervention groups, compared 3 30 control groups. Specifically, demonstrated diminishing duration symptoms while significantly accelerating viral symptomatic remission. FMT emerged particularly effective strategy, successfully restoring ameliorating gastrointestinal disorders. insights gleaned this contribute our broader comprehension therapeutic COVID-19-related mitigating secondary multi-organ complications.

Language: Английский

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High-dose vitamin D substitution in patients with COVID-19: study protocol for a randomized, double-blind, placebo-controlled, multi-center study—VitCov Trial

Trials, Journal Year: 2022, Volume and Issue: 23(1)

Published: Feb. 4, 2022

Abstract Background The coronavirus disease 19 (COVID-19) pandemic has caused millions of deaths, and new treatments are urgently needed. Factors associated with a worse COVID-19 prognosis include old age (> 65 years), ethnicity, male sex, obesity, people comorbidities. Furthermore, vitamin D deficiency was reported as predictor poor in patients acute respiratory failure due to COVID-19. According recent clinical case series, is modifiable risk factor, which the prospect reducing hospital stay, intensive care, fatal outcomes. Vitamin potent immunomodulatory properties, its supplementation might improve important outcomes critically ill D-deficient patients. Despite evidence that supports an association between severity, there uncertainty about direct link. Therefore, aim trial assess if high-dose therapeutic effect Methods As design, randomized, placebo-controlled, double-blind, multi-center approach chosen compare high single dose (140,000 IU) followed by treatment usual (TAU) (VitD + TAU) only (placebo deficiency. Discussion substitution should be investigated for efficacy safety. study test hypothesis suffering from treated under standardized conditions will recover faster when additionally supplementation. Latest studies suggest highly recommended positively influence course disease. With this randomized controlled trial, contribution guidelines shall made. Trial registration ClinicalTrials.gov NCT04525820 SNCTP 2020-01401

Language: Английский

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The impact of vitamin and mineral supplements usage prior to COVID-19 infection on disease severity and hospitalization

Bosnian Journal of Basic Medical Sciences, Journal Year: 2022, Volume and Issue: unknown

Published: Feb. 28, 2022

The COVID-19 pandemic has caused a global public health emergency. Nutritional status is suggested to be related the severity of infection. Herein, we aimed explore impact using vitamin and mineral supplements prior infection on disease hospitalization. In addition, use aspirin as an anticoagulant was investigated. A cross-sectional, self-administered survey conducted between March July 2021. Recovered individuals (age ≥ 18 years, n = 2148) were recruited in study. multivariate logistic regression used evaluate associations with hospitalization status. Among participants, 12.1% reported symptoms consistent severe COVID-19, 10.2% hospitalized due COVID-19. After adjustment for confounding variables (age, gender, BMI, cigarette smoking status, number comorbidities), model showed that consumption D associated significant decrease (OR 0.68, 95% CI 0.50 - 0.92; P 0.01), lower risk 0.64, 0.45 0.89; 0.01). On other hand, there no differences frequencies illness hospitalizations A, folic acid, B12, B complex, C, zinc, iron, selenium, calcium, magnesium, omega 3, before investigated nutrients, reduced However, more studies are required confirm this finding.

Language: Английский

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Vitamin D and COVID-19: Clinical Evidence and Immunological Insights

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 733 - 733

Published: April 30, 2025

Vitamin D has emerged as a potential modulator of immune responses, sparking interest in its role COVID-19 susceptibility and clinical outcomes. This review synthesizes current evidence explores immunological insights into the relationship between vitamin levels infection severity. Epidemiological studies indicate an inverse correlation deficiency increased risk severe disease, hospitalization, mortality patients. Immunologically, exerts regulatory effects on both innate adaptive immunity, enhancing antimicrobial defense mechanisms, reducing excessive inflammatory potentially mitigating cytokine storm events observed cases. Despite promising observational data, trials evaluating supplementation have shown mixed results, underscoring need for standardized dosing regimens patient stratification. Future research should focus large-scale randomized controlled to conclusively determine therapeutic optimal strategies managing COVID-19.

Language: Английский

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Microwave-assisted Click Synthesis of Levoglucosan Triazolyl Glycoconjugates using Ascorbyl palmitate sodium salt (Asp-Na) as a Green Co-catalyst

Carbohydrate Research, Journal Year: 2025, Volume and Issue: unknown, P. 109511 - 109511

Published: May 1, 2025

Language: Английский

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