Predictors of a metabolically unhealthy obesity

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2025, Volume and Issue: 24(2), P. 4212 - 4212

Published: Jan. 21, 2025

Over the past 50 years, number of obese people has increased many times. Despite excess weight, patients may be metabolically healthy. But studies show that this condition is an intermediate stage ending with a unhealthy phenotype, which associated increase in incidence cardiovascular events. The concept obesity characterized by altered levels various biomarkers, significance context predicting phenotype remains to studied. review devoted analysis modern research data on role hyperuricemia, gut microbiota and its metabolites, adipocytokines, as well assessment their relationship obesity.

Language: Английский

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VISCERAL ADIPOSITY AS A GLOBAL FACTOR OF CARDIOVASCULAR RISK

Russian Journal of Cardiology, Journal Year: 2018, Volume and Issue: 5, P. 7 - 14

Published: June 2, 2018

Obesity becomes one of the main risk factors development and progression cardiovascular diseases. Association high values body mass index with overall mortality is confirmed by results meta-analyses multiple prospective studies. On other hand, two most global problems this relationship — "obesity paradox" heterogeneity obesity phenotypes cardiometabolic risk, released discussions on issues predictive value overweight obesity, worth correction in patients under secondary prevention framework. Nowadays, fact became obvious that maximum role raise plays a specific type adipous tissue, morphological changes visceral tissue within processess remodeling inflammation, further dysfunction. In article, an assessment provided ethiopathogenetic continuum; review verification approaches to strategy proposed for stratification association broad clinical

Language: Английский

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Russian Society for the Prevention of Noncommunicable Diseases (ROPNIZ). Alimentary-dependent risk factors for chronic non-communicable diseases and eating habits: dietary correction within the framework of preventive counseling. Methodological Guidelines

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2021, Volume and Issue: 20(5), P. 2952 - 2952

Published: Sept. 16, 2021

The methodological guidelines are developed as a practical document for medical specialists working in the field of preventive medicine, order to expand and improve provision this type service adult population. include an informational informative part patients, presented format memos, contain main sections-healthy nutrition, correction eating habits, issues modifying diet alimentary-dependent risk factors chronic non-communicable diseases, such arterial hypertension, obesity, disorders lipid, carbohydrate purine metabolism, decrease bone mineral density. They intended prevention, doctors secondary personnel offices departments public health prevention centers, healthy lifestyle specialists, teachers educational institutions, who develop implement programs well therapeutic profile.

Language: Английский

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Obesity as a main component of metabolic syndrome and a risk factor for comorbidity

Experimental and Clinical Gastroenterology, Journal Year: 2024, Volume and Issue: 2, P. 101 - 110

Published: March 26, 2024

Obesity is an important medical and social problem, it occupies one of the leading places among cardiovascular risk factors. a major component metabolic syndrome. It has close pathogenetic relationship with its other manifestations, as result which portrait comorbid patient formed. The article presents data on prevalence, criteria for diagnosing obesity, obesity components syndrome shown. role adipose tissue dysfunction in development progression insulin resistance, atherosclerosis, well non-alcoholic fatty liver disease arterial hypertension discussed. shown that comorbidity factor basis syndrome, mechanism formation components, preceding their occurrence. This allows us to conclude weight loss can reduce risks, manifestations some cases even eliminate them completely.

Language: Английский

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Anthropometric indices obesity and cardiometabolic risk: is there a link?

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2021, Volume and Issue: 20(4), P. 2746 - 2746

Published: July 17, 2021

Adipose tissue is currently regarded as a key organ for excess dietary lipids, which determine whether the body will maintain normal homeostasis or inflammation and insulin resistance develop. In recent years, there more information about novel prognostic models — visceral adiposity index lipid accumulation product. The aim of this review was to analyze results studies examining relationship between various indices obesity cardiometabolic risk. We analyzed 105 literature sources, 53 were ruled out, becausethe processes interest not described in detail included anassessment with metabolic parameters. obtained indicate advisability using indices, have good predictive ability are simple convenient use. It necessary use additional methods anthropometric clinical examination order assess phenotype obesity, make it possible stratify patients by level

Language: Английский

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Influence of the initial state of the subcutaneous cell in overweight and obesity patients on the development of complications in the postoperative period

Issues of Reconstructive and Plastic Surgery, Journal Year: 2024, Volume and Issue: 26(4), P. 58 - 66

Published: Feb. 13, 2024

The World Obesity Federation published an atlas in 2023, which reports that if the current trend continues, 2035 every second person will be overweight or obese. Often, obese patients turn to a plastic surgeon for help, as “easiest way” solve this problem. Nevertheless, initial state of patient's health is fundamental obtain satisfying result both and patient aesthetic intervention. Therefore, thorough understanding pathomorphological processes occurring body with obesity necessary, determines relevance study. Purpose study: study morphological picture subcutaneous tissue obesity. Material methods. A immunohistochemical assessment was carried out 49 women who, period from 2019 2020, underwent planned surgical interventions indications aimed at correcting contours. After operation, were observed 6 months, assessing timing wound healing, well presence absence seromas, ligature fistulas, infection. We comparative analysis different course process, studied prognostic significance identified morphotypes relation risk delayed complicated healing. Results. Histological examination revealed two types adipose structure: adipocyte adipocyte-fibrous. type structure represented by itself typical mature adipocytes interadipocyte small capillaries, has lobular thin layers interlobular connective tissue. This mainly group standard postoperative period. mixed adipocyte-fibrous characterized ratio components - fatty fibrous. process established changes histological structure, cell infiltration increase number CD68+ positive macrophages HLA-DR+ immune cells, perivascular CD20+ B-lymphocytes fat indicates healing have already been admitted clinic local chronic inflammation Conclusion. during our can partially explain prolongation development complications patients. However, order create routine algorithm preoperative identification risk, it necessary identify correlations between biochemical blood

Language: Английский

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Obesity in the 21st Century. Prevalence, Phenotypes, Course Variants and Consequences

Bulletin of Science and Practice, Journal Year: 2024, Volume and Issue: 10(4), P. 268 - 303

Published: April 15, 2024

The review article examines the issues of obesity regarding its prevalence, phenotypes, course and consequences. anatomical, physiological functional features adipose tissue are discussed. “Discussion” section presents authors’ own clinical observations on therapeutic surgical in treatment obesity. Currently, is divided into white, brown beige. White can turn each other through beige stage. volume activity require greater expenditure metabolism oxygen molecules more pronounced women. components extracellular matrix collagen types I, III, V, VI. structure varies depending location, size fat, age, gender, state kidneys, thyroid gland, nature food, energy sleep patterns. With intense work cold exposure, hormone irisin formed skeletal muscles, which promotes transformation white or beige, helps reduce body weight obesity, has a beneficial effect type 2 diabetes mellitus associated diseases. Traditionally, obese individuals metabolically healthy unhealthy based degree metabolic disorders. In visceral lipolysis occurs with high intensity, supports development inflammation. decreased expression adiponectin accelerates atherosclerotic cardiovascular As increases, acquires an inflammatory phenotype, manifested by increased cytokines (interleukin-6, interleukin-1, interleukin-17, tumor necrosis factor-alpha), hyperactivation renin-angiotensin-aldosterone system, as well excessive cell infiltration immune system (leukocytes, neutrophils, T-lymphocytes, monocytes, macrophages). During inflammation tissue, (M1) atherogenic (M4) phenotypes macrophages dominate. morbid number reach up to 50% all cells.

Language: Английский

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Metabolic health of the population: a modern view of the problem and solutions

Russian Journal of Cardiology, Journal Year: 2024, Volume and Issue: 29(5), P. 5896 - 5896

Published: April 11, 2024

Studying the metabolic health of population around world is becoming a priority area modern medicine. This associated with an increase in prevalence overweight and obesity, which leads to significant related diseases, are actually complications primarily visceral. According 2019 data, obesity 5 million deaths 160 disability-adjusted life years, more than half due cardiovascular diseases. challenge requires development cardiometabolic medicine training new specialists.

Language: Английский

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The Association Between Obesity Phenotypes and Cardiovascular Diseases

Juvenis scientia, Journal Year: 2024, Volume and Issue: 10(2), P. 5 - 14

Published: April 30, 2024

Cardiovascular diseases and obesity are related medical social problems. However, some obese people remain free of cardiovascular disease for long periods time, the concept phenotypes that differ in risk has been actively studied. Currently, there no generally accepted diagnostic criteria them, mechanisms underlying their formation unclear. The purpose this article is to discuss literature data on phenotypes, relationship with mortality, as well place domestic algorithm diagnosing stable coronary heart disease.

Language: Английский

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Effectiveness of in insulin resistance correction and the adipokines level reduction in patients with arterial hypertension in comparison with other ARBs

Russian Journal of Cardiology, Journal Year: 2019, Volume and Issue: 1, P. 70 - 79

Published: Feb. 9, 2019

Aim. To assess the possibility of azilsartan medoxomil to achieve target blood pressure (BP) (less than 130/80 mm Hg), study angioprotective features and reduction adipokines levels inflammatory markers in patients with hypertension previous therapy other ARBs. Material methods . In open observational 24 weeks follow-up were included 60 (losartan or valsartan telmisartan). All underwent ambulatory BP monitoring, applanation tonometry (determination augmentation index central BP), measurement pulse wave velocity, laboratory tests (lipid profile, uric acid, fasting glucose, Homeostasis Model Assessment, homocysteine, leptin, adiponectin, highly sensitive C-reactive protein, tumor necrosis factor alpha, interleukin-6). Results. Azilsartan provided systolic (29,05%, 22,5% 8,9%) diastolic 18,82%, 20,46% 8,54% (p<0,05) previously treated losartan, telmisartan, respectively. Central (by 25,95%, 8,78%, 11,94%), 40%, 18,38% 19,6%), 28,87%, 20,69% 14,29%) velocity 21,57%, 24,56% 24,92%) decreased (p<0,05). There positive changes IL-6, adiponectin all telmisartan initial Conclusion. has advantages control, arterial elasticity improving, reducing insulin-resistance inflammation.

Language: Английский

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