Near-Infrared-II-Activatable Self-Assembled Manganese Porphyrin-Gold Heterostructures for Photoacoustic Imaging-Guided Sonodynamic-Augmented Photothermal/Photodynamic Therapy

ACS Nano, Год журнала: 2023, Номер 18(1), С. 713 - 727

Опубликована: Дек. 20, 2023

Porphyrins and their derivatives are widely used as photosensitizers sonosensitizers in tumor treatment. Nevertheless, poor water solubility low chemical stability reduce singlet oxygen (1O2) yield and, consequently, photodynamic therapy (PDT) sonodynamic (SDT) efficiency. Although strategies for porphyrin molecule assembly have been developed to augment 1O2 generation, there is scope further improving PDT SDT efficiencies. Herein, we synthesized ordered manganese (SM) nanoparticles with well-defined self-assembled metalloporphyrin networks that enabled efficient energy transfer enhanced photocatalytic sonocatalytic activity production. Subsequently, Au were grown situ on the SM surface by anchoring terminal alkynyl of form plasmonic SMA heterostructures, which showed excellent near-infrared-II (NIR-II) region absorption photothermal properties, facilitated electron–hole pair separation transfer. With modification hyaluronic acid (HA), SMAH heterostructure nanocomposites exhibited good actively targeted cancer cells. Under NIR-II light ultrasound (US) irradiation, generates hyperthermia, a large amount 1O2, inducing cell damage. Both vitro vivo studies confirmed effectively suppressed growth decreasing GSH levels SDT-augmented PDT/PTT. Moreover, utilizing strong window, can achieve photoacoustic imaging-guided combined This work provides paradigm enhancing metalloporphyrins improve synergistic therapeutic effect SDT/PDT/PTT.

Язык: Английский

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Strategies to engineer various nanocarrier-based hybrid catalysts for enhanced chemodynamic cancer therapy

Chemical Society Reviews, Год журнала: 2023, Номер 52(22), С. 7707 - 7736

Опубликована: Янв. 1, 2023

This review summarizes the strategies to engineer CDT nanocatalysts based on diverse nanocarriers, especially those with intrinsic therapeutic activities.

Язык: Английский

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Piezoelectric Biomaterials Inspired by Nature for Applications in Biomedicine and Nanotechnology

Advanced Materials, Год журнала: 2024, Номер 36(35)

Опубликована: Июнь 22, 2024

Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.

Язык: Английский

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A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Год журнала: 2024, Номер 20(25)

Опубликована: Янв. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Язык: Английский

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Doping Engineering of Piezo‐Sonocatalytic Nanocoating Confer Dental Implants with Enhanced Antibacterial Performances and Osteogenic Activity

Advanced Functional Materials, Год журнала: 2024, Номер 34(21)

Опубликована: Янв. 30, 2024

Abstract Rescuing dental implants from plaque‐induced infection and implementing effective plaque control methods in a limited oral environment pose challenges for modern dentistry. To address this issue, Al ion doped strontium titanate/titanium dioxide nanotubes (Al‐SrTiO 3 /TiO 2 nanotubes, Al‐STNT) are designed as an ultrasound‐responsive nanocoating immobilized on the Ti implant surface. Introducing 3+ ions into inorganic sonosensitive SrTiO heterojunction induces oxygen vacancies disrupts lattice of . By overcoming bandgap barrier through ultrasonic stimulated piezoelectric effect, Al‐STNT produces more reactive species (ROS). In sonodynamic therapy (SDT) process, stimulus abundant ROS efficiently disrupting bacteria biofilm inhibiting metabolism. Moreover, specific nanoscale coating endows with osteogenic activity, facilitating formation rigid osseointegration between surface alveolar bone. mimicking human rats, demonstrates optimal postimplant while retaining its antibacterial ability sonosensitizer. Thanks to portability ultrasound instrument stability implant‐based sonosensitizer, strategy presents attractive option patients self‐treat secure long‐term success their implants.

Язык: Английский

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Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Год журнала: 2024, Номер 36(27)

Опубликована: Март 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Язык: Английский

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A Tribo/Piezoelectric Nanogenerator Based on Bio‐MOFs for Energy Harvesting and Antibacterial Wearable Device

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Abstract New types of metal–organic framework (MOF) materials have great potential in solving the current global dilemma on energy, environment, and medical care. Herein, based two kinds biomolecule‐MOFs (Bio‐MOFs) with favorable biocompatibility degradation‐reconstruction characteristics, we established a self‐powered muti‐functional device to achieve an efficient broad‐spectrum environmental energy collection biomedical applications. Combining Zn(II) carnosine‐based Zn‐Car_MOF possessing high piezoelectric response ( d 33 = 11.17 pm V −1 ) patterned polydimethylsiloxane (PDMS) film, tribo‐piezoelectric hybrid nanogenerator (TPHG) is constructed synergy output triboelectric effects. The Zn‐Car_TPHG demonstrates performance (131 at 100 kPa) wide range pressure (1 Pa–100 kPa), applications sensors. To expand application wearable device, conductive hexagonal prism MOF (Cu 3 (2,3,6,7,10,11‐hexahydroxytriphenylene) 2 (Cu‐HHTP)) synthesized employed load thymol (Thy). Cooperating Zn‐Car_TPHG, resulting Cu‐HHTP/Thy can ROS (singlet oxygen 1 O hydroxyl radical (·OH)) generation drug synergistic sterilization effect (efficiency ≥ 98%). In word, flexible Bio‐MOFs sustainable environmentally friendly, fields collection, biosensors, antibacterial.

Язык: Английский

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Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and subsequent release DNA (mtDNA), which is anticipated to activate cGAS-STING pathway, thereby augmenting antitumor immune response. However, challenges lie in effectively triggering cancer cells subsequently enhancing activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 a semiconductor structure enzyme-like activity generated substantial amount reactive oxygen species (ROS) under stimulation by endogenous H2O2 exogenous ultrasound. Importantly, discovered that Co-based nanomaterials themselves induce cells. Therefore, initially acted as inducers, caspase-1/GSDMD-dependent via Co2+ ROS, leading mtDNA release. Subsequently, were further utilized STING agonists specifically capable detecting pathway. These cascade events triggered robust response, modulating immunosuppressive tumor microenvironment into an immune-supportive state, providing favorable support therapy. This innovative strategy not only significantly impeded growth primary but also elicited response augment efficacy checkpoint inhibitors preventing distant progression. Overall, this study proposed self-cascade activating amplifying pathway specificity mediated pyroptosis, representing valuable avenue future

Язык: Английский

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Sono‐Piezo Dynamic Therapy: Utilizing Piezoelectric Materials as Sonosensitizer for Sonodynamic Therapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Sonodynamic therapy (SDT) represents a promising approach for cancer treatment. Compared to photodynamic therapy, SDT offers increased penetration depth and higher precision. However, the practical application of is constrained by low water solubility, poor tumor specificity, metabolic susceptibility most sonosensitizers. Recent research has explored use piezoelectric materials as sonosensitizers in treatment inhibition bacterial growth. Upon ultrasound excitation, separation electron-hole (e--h+) pairs occurs within material. By improving crystal structure material or incorporating other nanoparticles prevent rapid recombination e--h+ pairs, accumulates charges conduction band valence band, achieving redox potential O2/·O2 -. This enables serve sonosensitizer, leading concept termed Sono-Piezo Dynamic Therapy (SPDT). review aims define SPDT, provide systematic overview historical development SDT, elucidate mechanisms which act Importantly, various will be discussed terms their feasibility, advantages, disadvantages sonosensitizers, offering new perspectives identifying

Язык: Английский

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One Stone, Three Birds: Design and Synthesis of “All-in-One” Nanoscale Mn-Porphyrin Coordination Polymers for Magnetic Resonance Imaging-Guided Synergistic Photodynamic-Sonodynamic Therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 660, С. 1021 - 1029

Опубликована: Янв. 24, 2024

Язык: Английский

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