Abstract
New
benzimidazole‐based
piperazine
analogues
(
9
a
–
n
)
were
synthesized
and
screened
for
their
cytotoxicity
against
human
breast
cancer
cell
lines
MCF‐7
MDA‐MB‐231
by
employing
Doxorubicin
as
standard
reference.
4‐(trifluoromethyl)benzyl
substituted
compound
f
displayed
outstanding
activity
both
line
with
IC
50
value
of
7.29±0.20
μM
6.92±4.80
respectively,
compared
to
.
Additionally,
butyl
m
showed
superior
cells
7.61±5.90
4‐fluorobenzyl
c
indicated
on
par
the
an
9.15±0.10
The
morphological
study
active
compounds
revealed
have
not
shown
any
toxicity
MCF‐10A
cells.
Molecular
docking
all
Cyclin‐dependent
kinase
6
produced
notable
binding
energies
interactions
in
comparison
co‐crystalized
ligand
Abemaciclib
Pharmacokinetic
evaluation
presented
favourable
drug‐likeness
properties.
Critical Reviews in Analytical Chemistry,
Год журнала:
2022,
Номер
54(6), С. 1810 - 1836
Опубликована: Окт. 17, 2022
Organic
compounds
display
several
electronic
and
structural
features
which
enable
their
application
in
various
fields,
ranging
from
biological
to
non-biological.
These
contain
heteroatoms
like
sulfur,
nitrogen
oxygen,
provide
coordination
sites
act
as
ligands
the
field
of
chemistry
are
used
chemosensors
detect
metal
ions.
This
review
article
covers
different
organic
including
thiourea,
Schiff
base,
pyridine,
thiophene,
coumarin,
triazolyl
pyrenes,
imidazole,
fluorescein,
thiazole,
tricarbocyanine,
rhodanine,
porphyrin,
hydrazone,
benzidine
other
functional
groups
based
chemosensors,
that
and,
oxygen
for
fluorimetric
colorimetric
detection
Ag
Saudi Pharmaceutical Journal,
Год журнала:
2023,
Номер
31(9), С. 101698 - 101698
Опубликована: Июль 7, 2023
Indole,
benzoxazole
benzothiazole
and
benzimidazole
are
excellent
classes
of
organic
heterocyclic
compounds.
These
compounds
show
significant
application
in
pharmacy,
industries,
dyes,
medicine,
polymers
food
packages.
also
form
metal
complexes
with
copper,
zinc,
cadmium,
nickel,
cobalt,
platinum,
gold,
palladium
chromium,
silver,
iron,
other
metals
that
have
shown
to
be
applications.
Recently,
researchers
attracted
enormous
attention
toward
such
as
indole,
benzimidazole,
benzothiazole,
benzoxazole,
their
due
medicinal
applications
anti-ulcerogenic,
anti-cancer,
antihypertensive,
antifungal,
anti-inflammatory,
antitubercular,
antiparasitic,
anti-obesity,
antimalarial,
antiglycation,
antiviral
potency,
antineuropathic,
analgesic
antioxidant,
antihistaminic,
antibacterial
potentials.
In
this
article,
we
summarize
the
these
well
complexes.
We
hope
article
will
help
designing
synthesizing
novel
potent
various
fields.
Chemical Biology & Drug Design,
Год журнала:
2023,
Номер
102(2), С. 357 - 376
Опубликована: Апрель 3, 2023
Cancer
is
the
second
leading
cause
of
death
globally,
with
9.6
million
deaths
yearly.
As
a
life-threatening
disease,
it
necessitates
emergence
new
therapies.
Resistance
to
current
chemotherapies
drives
scientists
develop
medications
that
will
eventually
be
accessible.
Because
heterocycles
are
so
common
in
biological
substances,
compounds
play
big
part
variety
have
been
developed.
The
"Master
Key"
benzimidazole
nucleus,
which
consists
six-membered
benzene
ring
fused
five-membered
imidazole/imidazoline
ring,
an
azapyrrole.
One
aromatic
nitrogen
identified
American
therapies
approved
by
Food
and
Drug
Administration
(FDA).
Our
results
show
benzimidazole's
broad
therapeutic
spectrum
due
its
structural
isosteres
purine,
improves
hydrogen
bonding,
electrostatic
interactions
topoisomerase
complexes,
intercalation
DNA,
other
functions.
It
also
enhances
protein
nucleic
acid
inhibition,
tubulin
microtubule
degeneration,
apoptosis,
DNA
fragmentation,
Additionally,
readers
for
designing
more
recent
analogues
as
prospective
cancer
treatments.
Expert Opinion on Therapeutic Patents,
Год журнала:
2022,
Номер
32(3), С. 299 - 315
Опубликована: Янв. 6, 2022
Benzothiazole
is
a
bicyclic
ring
system
composed
of
thiazole
and
benzene
rings.
It
present
as
an
important
pharmacophore
in
many
marketed
drugs.
The
notable
potential
benzothiazoles
therapeutic
agent
for
different
target
diseases
has
prompted
growing
interest
benzothiazole-based
drug
development
recent
years.This
review
55
benzothiazole-related
patents,
filed
from
2015
to
2020,
covers
wide
range
pharmacological
activities.
These
patents
were
collated
Google
Patents
Lens
search
engines.
inventions
categorized
discussed
based
on
their
respective
group
diseases,
including
metabolic
cancer,
inflammation,
neurodegeneration,
viral
bacterial
infections,
fibrosis
thrombosis.Benzothiazole
shown
be
scaffold
with
great
importance
thus,
serves
building
block
the
derivatives
having
high
activity.
patented
applications,
special
focus
cancer
research.
Several
compounds
have
progress
into
market,
given
that
they
exert
both
selectivity
vivo
efficacy.
Others
require
more
thorough
study
obtain
adequate
information
compounds.
Abstract
Cancer,
one
of
the
most
deadly
diseases
worldwide,
is
still
a
crucial
challenge
to
human
well‐being.
Hence,
design
and
development
modern
protocols
cure
diverse
kinds
cancer
seem
highly
necessary.
On
other
hand,
benzimidazole,
as
an
essential
pharmacophore,
exhibits
various
biological
therapeutic
potency.
This
compound
well‐known
for
its
pharmaceutical
features,
including
antifungal,
antiviral,
antibacterial,
anticancer
activities.
Therefore,
benzimidazole
derivatives
have
played
role
due
their
outstanding
capability,
apoptotic
effect,
inhibitory
potential.
In
recent
decades,
numerous
drug
types
research
been
concentrated
on
finding
new
practical
strategies
employing
benzimidazole‐based
compounds.
review
focuses
latest
advancements
methodologies
exploiting
benzimidazole‐bearing
compounds
treatment
varied
sorts
cancer,
considering
mechanism
function
against
cell
lines.
