Progress in biomaterials inspired by the extracellular matrix DOI Creative Commons

Zhuolin Chen,

Chengcheng Du, Senrui Liu

и другие.

Giant, Год журнала: 2024, Номер 19, С. 100323 - 100323

Опубликована: Июль 10, 2024

Inspired by the extracellular matrix (ECM), biomaterials have emerged as promising strategies in biomedical research and engineering domain, offering unique characteristics for tissue regeneration, drug delivery, therapeutic interventions, cellular investigations. The ECM, a dynamic network structure secreted various cells, primarily comprises diverse proteins capable of facilitating tissue-ECM signaling regulatory functions through its rich array bioactive substances multi-level structural properties. Drawing inspiration from intricate biochemical composition natural researchers developed to encapsulate these features create biomimetic microenvironments, such electrospinning, hydrogels/hydrogel microspheres, decellularized ECM(dECM), ECM-mimicking peptides. Furthermore, mimicking ECM components, ECM-inspired exhibit varying degrees functionalization, including providing support, cell adhesion, signal transduction, mitigating immune responses, remodeling. In summary, advancements offer significant promise addressing key challenges fields engineering, regenerative medicine, delivery.

Язык: Английский

Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer DOI Creative Commons
Yuan Xiong, Qian Feng, Li Lü

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 33(10)

Опубликована: Янв. 1, 2023

Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune microenvironment are comprehensively reviewed. The pathological features healing processes DFUs, followed by summarizing physicochemical properties essential design immunomodulation briefly introduced. Then, potential immuno‐therapeutic modalities emerging trends used treat via multitherapeutic approaches enhanced efficacy safety discussed. Taken together, linking structural their functions therapy with a particular focus on immunomodulatory stimuli, this review can promote further designing advanced resulting improved diabetic wound repair through translation into setting near future.

Язык: Английский

Процитировано

72

Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives DOI Creative Commons

Anthony Ko,

Caizhi Liao

BMEMat, Год журнала: 2023, Номер 1(3)

Опубликована: Июнь 30, 2023

Abstract Diabetic foot ulcers (DFU) are a common and often debilitating complication of diabetes that can result in lower limb amputations if left untreated. Hydrogel dressings three‐dimensional networks hydrophilic polymers absorb retain large amounts water, have been shown to possess excellent biocompatibility, low toxicity, fluid handling properties. In addition, hydrogels create moist wound environment promotes healing by supporting cell proliferation, migration, angiogenesis. Hydrogels, therefore, emerged as promising for promoting DFU healing. this review, we attempt chart the landscape emerging field hydrogel dressing treatment. We will explicitly review assorted preparation methods well detailed discussion various types deployed study. also crystallize key findings, identify remaining challenges, present an outlook on future development enticing field.

Язык: Английский

Процитировано

67

Intelligent biobased hydrogels for diabetic wound healing: A review DOI
Hanzhang Wang, Liming Zhang

Chemical Engineering Journal, Год журнала: 2024, Номер 484, С. 149493 - 149493

Опубликована: Фев. 10, 2024

Язык: Английский

Процитировано

56

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine DOI
Ben Jia,

Heyuan Huang,

Zhicheng Dong

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер 53(8), С. 4086 - 4153

Опубликована: Янв. 1, 2024

This review critically analyzes degradable biomedical elastomers, focusing on their degradation, synthesis, microstructure, and role in tissue repair. It guides experts balancing degradation with repair for improved applications.

Язык: Английский

Процитировано

49

Hydrogel-based dressings designed to facilitate wound healing DOI Creative Commons
Wei Zhang, Lulu Liu, Hui Cheng

и другие.

Materials Advances, Год журнала: 2023, Номер 5(4), С. 1364 - 1394

Опубликована: Дек. 20, 2023

This review provides an overview of the functionalities hydrogel-based dressings and their role in promoting wound healing.

Язык: Английский

Процитировано

43

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration DOI Creative Commons
Amal George Kurian, Rajendra K. Singh,

Varsha Sagar

и другие.

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Язык: Английский

Процитировано

38

Hydrogel-Based Skin Regeneration DOI Open Access
Zohreh Arabpour, Farshad Abedi, Majid Salehi

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 1982 - 1982

Опубликована: Фев. 6, 2024

The skin is subject to damage from the surrounding environment. repair of wounds can be very challenging due several factors such as severe injuries, concomitant infections, or comorbidities diabetes. Different drugs and wound dressings have been used treat wounds. Tissue engineering, a novel therapeutic approach, revolutionized treatment regeneration tissue damage. This field includes use synthetic natural biomaterials that support growth tissues organs outside body. Accordingly, demand for polymer-based strategies defects significantly increasing. Among various 3D scaffolds in hydrogel gained special significance their unique properties mimicry extracellular matrix (ECM), moisture retention, porosity, biocompatibility, biodegradability, biocompatibility properties. First, this article delineates process healing conventional methods treating It then presents an examination structure manufacturing hydrogels, followed by analysis crucial characteristics most recent advancements using purpose. Finally, it discusses potential future materials within realm healing.

Язык: Английский

Процитировано

36

Recent progress of electrospun nanofibers as burning dressings DOI Creative Commons
Shengwei Zhang, Wei Yang,

Wenjian Gong

и другие.

RSC Advances, Год журнала: 2024, Номер 14(20), С. 14374 - 14391

Опубликована: Янв. 1, 2024

Burns are a global public health problem, which brings great challenges to and the economy.

Язык: Английский

Процитировано

22

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review DOI Open Access
Gabriel Olteanu,

Sorinel Marius Neacșu,

FLORIN ALEXANDRU JOIȚA

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3849 - 3849

Опубликована: Март 29, 2024

This state-of-the-art review explores the emerging field of regenerative hydrogels and their profound impact on treatment skin wounds. Regenerative hydrogels, composed mainly water-absorbing polymers, have garnered attention in wound healing, particularly for Their unique properties make them well suited tissue regeneration. Notable benefits include excellent water retention, creating a crucially moist environment optimal facilitating cell migration, proliferation. Biocompatibility is key feature, minimizing adverse reactions promoting natural healing process. Acting as supportive scaffold growth, mimic extracellular matrix, aiding attachment proliferation cells like fibroblasts keratinocytes. Engineered controlled drug release, enhance by angiogenesis, reducing inflammation, preventing infection. The demonstrated acceleration process, beneficial chronic or impaired wounds, adds to appeal. Easy application conformity various shapes practical, including irregular challenging areas. Scar minimization through regeneration crucial, especially cosmetic functional regions. Hydrogels contribute pain management protective barrier, friction, fostering soothing environment. Some with inherent antimicrobial properties, aid infection prevention, which crucial aspect successful healing. flexibility ability conform contours ensure contact, enhancing overall effectiveness. In summary, present promising approach improving outcomes across diverse clinical scenarios. provides comprehensive analysis benefits, mechanisms, challenges associated use this review, authors likely delve into rational design principles efficacy performance Through an exploration methodologies approaches, paper poised highlight how these been instrumental refining potentially revolutionizing therapeutic potential addressing By synthesizing current knowledge highlighting avenues future research, aims advancement medicine ultimately improve patients

Язык: Английский

Процитировано

21

Research progress of natural polysaccharide-based and natural protein-based hydrogels for bacteria-infected wound healing DOI

XU Hui-qing,

Yilin Che,

Rui Zhou

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 153803 - 153803

Опубликована: Июль 6, 2024

Язык: Английский

Процитировано

21