Vascular Health and Risk Management,
Год журнала:
2023,
Номер
Volume 19, С. 237 - 253
Опубликована: Апрель 1, 2023
Purpose
of
Review:
The
relationship
between
cardiovascular
health
and
diet
is
evolving.
Lifestyle
modifications
including
changes
are
the
primary
approach
in
managing
cardiometabolic
risk
factors.
Thus,
understanding
different
diets
their
impact
on
important
guiding
secondary
prevention
disease
(CVD).
Yet,
there
many
barriers
limitations
to
adopting
a
heart
healthy
diet.
Recent
Findings:
Diets
rich
fruits,
vegetables,
legumes,
whole
grains,
lean
protein
sources,
with
minimization/avoidance
processed
foods,
trans-fats,
sugar
sweetened
beverages,
recommended
by
guidelines.
Mediterranean,
DASH,
plant-based
have
all
proven
cardioprotective
varying
degrees
endorsed
professional
healthcare
societies,
while
other
emerging
such
as
ketogenic
intermittent
fasting
require
more
long-term
study.
effects
gut
microbiome
opened
new
path
for
precision
medicine
improve
certain
dietary
metabolites,
trimethylamine
N-oxide,
factors,
along
diversity
gene
pathways
relation
CVD
management,
being
explored.
Summary:
In
this
review,
we
provide
comprehensive
up-to-date
overview
established
health.
We
discuss
effectiveness
various
most
importantly
approaches
nutritional
counseling
where
traditional
non-traditional
practiced,
helping
patients
adopt
diets.
address
regarding
food
insecurity,
poor
access,
socioeconomic
burden.
Lastly,
need
multidisciplinary
team-based
approach,
role
nutrition
specialist,
implementing
culturally-tailored
recommendations.
Understanding
finding
ways
overcome
heart-healthy
will
take
us
miles
management.
Keywords:
disease,
diet,
guidelines,
nutrition,
disparities,
Clocks & Sleep,
Год журнала:
2023,
Номер
5(3), С. 507 - 535
Опубликована: Сен. 6, 2023
Achieving
synchronization
between
the
central
and
peripheral
body
clocks
is
essential
for
ensuring
optimal
metabolic
function.
Meal
timing
an
emerging
field
of
research
that
investigates
influence
eating
patterns
on
our
circadian
rhythm,
metabolism,
overall
health.
This
narrative
review
examines
relationship
meal
timing,
clock
genes,
hormones,
It
analyzes
existing
literature
experimental
data
to
explore
connection
mealtime,
rhythms,
processes.
The
available
evidence
highlights
importance
aligning
mealtime
with
body’s
natural
rhythms
promote
health
prevent
disorders.
Specifically,
studies
show
consuming
meals
later
in
day
associated
elevated
prevalence
disorders,
while
early
time-restricted
eating,
such
as
having
breakfast
earlier
dinner,
improves
levels
glucose
blood
substrate
oxidation.
Circadian
including
cortisol
melatonin,
interact
mealtimes
play
vital
roles
regulating
Cortisol,
aligned
dawn
diurnal
mammals,
activates
energy
reserves,
stimulates
appetite,
influences
gene
expression,
synchronizes
clocks.
Consuming
during
periods
melatonin
levels,
specifically
night,
has
been
correlated
potential
implications
tolerance.
Understanding
mechanisms
synchronization,
genetics,
interactions
chronotype,
sleep
duration,
hormonal
changes,
provides
valuable
insights
optimizing
dietary
strategies
timing.
knowledge
contributes
improved
well-being
by
rhythm.
Current Obesity Reports,
Год журнала:
2025,
Номер
14(1)
Опубликована: Фев. 13, 2025
Abstract
Purpose
of
the
Review
This
review
summarizes
recent
evidence
for
a
role
clock
in
adipose
tissue
physiology
and
impact
circadian
desynchrony
on
development
obesity.
Recent
Findings
Circadian
disruptions
due
to
shift
work,
late
time
eating
nighttime
light
exposure
are
associated
with
obesity
its
metabolic
cardiovascular
consequences.
Studies
mice
harboring
tissue-specific
gain/loss
function
mutations
genes
revealed
that
acts
multiple
pathways
control
adipogenesis,
lipogenesis/lipolysis
thermogenesis.
Time-restricted
(TRE),
aligning
feeding
active
period
restore
function,
represents
promising
strategy
curb
Summary
While
TRE
has
shown
clear
benefits,
especially
participants
at
higher
cardiometabolic
risk,
current
studies
limited
size
duration.
Larger,
well-controlled
warranted
conclusively
assess
effects
relation
status
gender.
Field
shift-workers,
comparing
permanent
night
versus
rotating
shifts,
also
necessary
identify
optimal
window
TRE.
Abstract
Time‐restricted
feeding
(TRF)
holds
promise
for
alleviating
cognitive
decline
in
aging,
albeit
the
precise
mechanism
via
gut‐brain
axis
remains
elusive.
In
a
clinical
trial,
we
observed,
first
time,
that
4‐month
TRF
ameliorated
impairments
among
Alzheimer's
disease
(AD)
patients.
Experiments
5xFAD
mice
corroborated
gut
microbiota‐dependent
effect
of
on
mitigating
dysfunction,
amyloid‐beta
deposition,
and
neuroinflammation.
Multi‐omics
integration
linked
Bifidobacterium
pseudolongum
(
B.
)
propionic
acid
(PA)
with
key
genes
AD
pathogenesis.
Oral
supplementation
or
PA
mimicked
TRF's
protective
effects.
Positron
emission
tomography
imaging
confirmed
PA's
blood‐brain
barrier
penetration,
while
knockdown
free
fatty
receptor
3
(FFAR3)
diminished
benefits.
Notably,
observed
positive
correlation
between
fecal
improved
function
an
cohort,
further
indicating
enhanced
production.
These
findings
highlight
microbiota‐metabolites‐brain
as
pivotal
benefits,
proposing
potential
therapies.
Overnutrition
is
a
risk
factor
for
various
human
diseases,
including
neurodegenerative
metabolic
disorders,
and
cancers.
Therefore,
targeting
overnutrition
represents
simple
but
attractive
strategy
the
treatment
of
these
increasing
public
health
threats.
Fasting
as
dietary
intervention
combating
has
been
extensively
studied.
practiced
millennia,
only
recently
have
its
roles
in
molecular
clock,
gut
microbiome,
tissue
homeostasis
function
emerged.
can
slow
aging
most
species
protect
against
These
centuried
unfading
adventures
explorations
suggest
that
fasting
potential
to
delay
help
prevent
treat
diseases
while
minimizing
side
effects
caused
by
chronic
interventions.
In
this
review,
recent
animal
studies
concerning
role
underlying
mechanism
physiology
pathology
are
summarized,
therapeutic
highlighted,
combination
pharmacological
discussed
new
regimen
diseases.
Gut,
Год журнала:
2023,
Номер
72(8), С. 1607 - 1619
Опубликована: Июнь 7, 2023
Non-alcoholic
fatty
liver
disease
(NAFLD)
represents
a
major
public
health
concern
and
is
associated
with
substantial
global
burden
of
liver-related
cardiovascular-related
morbidity
mortality.
High
total
energy
intake
coupled
unhealthy
consumption
ultra-processed
foods
saturated
fats
have
long
been
regarded
as
dietary
drivers
NAFLD.
However,
there
an
accumulating
body
evidence
demonstrating
that
the
timing
across
day
also
important
determinant
individual
risk
for
NAFLD
metabolic
conditions.
This
review
summarises
available
observational
epidemiological
data
describing
associations
between
eating
patterns
disease,
including
negative
effects
irregular
meal
patterns,
skipping
breakfast
night-time
on
health.
We
suggest
these
harmful
behaviours
deserve
greater
consideration
in
stratification
management
patients
particularly
24-hour
society
continuous
availability
food
up
to
20%
population
now
engaged
shiftwork
mistimed
patterns.
draw
studies
reporting
liver-specific
impact
Ramadan,
which
unique
real-world
opportunity
explore
physiological
fasting.
By
highlighting
from
preclinical
pilot
human
studies,
we
present
further
biological
rationale
manipulating
improve
discuss
how
this
may
be
mediated
through
restoration
natural
circadian
rhythms.
Lastly,
comprehensively
landscape
trials
intermittent
fasting
time-restricted
offer
look
future
about
strategies
benefit
non-alcoholic
steatohepatitis.
