Piezoelectric Biomaterials Inspired by Nature for Applications in Biomedicine and Nanotechnology

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 22, 2024

Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.

Language: Английский

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A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Language: Английский

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Mechanical energy harvesting based on the piezoelectric materials: Recent advances and future perspectives

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154249 - 154249

Published: July 30, 2024

Language: Английский

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Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(4), P. 114 - 114

Published: March 24, 2025

Cancer significantly impacts human quality of life and expectancy, with an estimated 20 million new cases 10 cancer-related deaths worldwide every year. Standard treatments including chemotherapy, radiotherapy, surgical removal, for aggressive cancers, such as glioblastoma, are often ineffective in late stages. Glioblastoma, example, is known its poor prognosis post-diagnosis, a median survival time approximately 15 months. Novel therapies using local electric fields have shown anti-tumour effects glioblastoma by disrupting mitotic spindle assembly inhibiting cell growth. However, constant application poses risks like patient burns. Wireless stimulation via piezoelectric nanomaterials offers safer alternative, requiring ultrasound activation to induce therapeutic effects, altering voltage-gated ion channel conductance depolarising membrane potentials. This review highlights the mechanism, drug delivery, activation, current technologies cancer therapy, emphasising need further research address limitations biocompatibility whole systems. The goal underscore these areas inspire avenues overcome barriers developing nanoparticle-based therapies.

Language: Английский

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Advances in near-infrared-activated lanthanide-doped optical nanomaterials: imaging, sensing, and therapy

Materials & Design, Journal Year: 2023, Volume and Issue: 231, P. 112036 - 112036

Published: May 25, 2023

As the population ages, cancer has become a major health concern. Although surgical treatment, chemoradiotherapy, and other clinical treatments have dominant, their strong invasiveness intolerable toxic side effects seriously affect patients' quality of life. Therefore, developing non-invasive optical therapy with high safety is great significance. In last two decades development, progress been made in lanthanide doped nanoparticles on biomedical applications under near-infrared (NIR) light due to unique properties. These nanomaterials used wide range applications, including bioluminescence marker detection, vitro vivo imaging, photodynamic (PDT), photothermal (PTT), therapeutic applications. therapies rapidly developed profession involving oncology non-invasive, spatiotemporal controllability, efficiency. For this key review, based listed as follows: bioimaging, biosensors, PDT PTT. Some emerging biological lanthanide-doped currently at forefront nano/biological interface are also discussed. Finally, review summarizes future opportunities challenges nanotechnology research nanoparticles.

Language: Английский

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Near‐Infrared‐Responsive Rare Earth Nanoparticles for Optical Imaging and Wireless Phototherapy

Advanced Science, Journal Year: 2023, Volume and Issue: 11(8)

Published: Nov. 9, 2023

Abstract Near‐infrared (NIR) light is well‐suited for the optical imaging and wireless phototherapy of malignant diseases because its deep tissue penetration, low autofluorescence, weak scattering, non‐invasiveness. Rare earth nanoparticles (RENPs) are promising NIR‐responsive materials, owing to their excellent physical chemical properties. The 4f electron subshell lanthanides, main group rare elements, has rich energy‐level structures. This facilitates broad‐spectrum light‐to‐light conversion other forms energy, such as thermal energies. In addition, abundant loadable modifiable sites on surface offer favorable conditions functional expansion RENPs. this review, authors systematically discuss processes mechanisms underlying response RENPs NIR summarize recent advances in applications imaging, photothermal therapy, photodynamic photoimmunotherapy, optogenetics, light‐responsive drug release. Finally, challenges opportunities application under activation considered.

Language: Английский

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Interplay of piezoelectricity and electrical stimulation in tissue engineering and regenerative medicine

Applied Materials Today, Journal Year: 2024, Volume and Issue: 39, P. 102332 - 102332

Published: July 20, 2024

Language: Английский

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Synergizing Pyroelectric Catalysis and Enzyme Catalysis: Establishing a Reciprocal and Synergistic Model to Enhance Anti‐Tumor Activity

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)

Published: Feb. 27, 2024

Nanozyme activity is greatly weakened by the microenvironment and multidrug resistance of tumor cells. Hence, a bi-catalytic nanoplatform, which promotes anti-tumor through "charging empowerment" "mutual complementation" processes involved in enzymatic pyroelectric catalysis, loading ultra-small nanoparticles (USNPs) ZnSnO

Language: Английский

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Recent advancements in bio-based dielectric and piezoelectric polymers and their biomedical applications

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(22), P. 5272 - 5298

Published: Jan. 1, 2024

Bio-based polymers possess distinctive dielectric and piezoelectric properties that make them extremely attractive in a variety of biomedical applications.

Language: Английский

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Piezoelectric Catalysis Induces Tumor Cell Senescence to Boost Chemo‐Immunotherapy

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 10, 2024

Abstract Cellular senescence, a vulnerable state of growth arrest, has been regarded as potential strategy to weaken the resistance tumor cells, leading dramatic improvements in treatment efficacy. However, selective and efficient for inducing local cellular senescence not yet reported. Herein, piezoelectric catalysis is utilized reduce intracellular NAD + NADH cell first time. In detail, biocompatible nanomedicine (BTO/Rh‐D@M) constructed by wrapping BaTiO 3 /(Cp * RhCl 2 ) (BTO/Rh) doxorubicin (DOX) homologous cytomembrane with target. After tumors are stimulated ultrasound, negative positive charges generated on BTO/Rh catalysis, which oxidize H O reactive oxygen species (ROS) mitochondrial damage. Thus, therapeutic efficacy immunogenic death‐induced chemo‐immunotherapy boosted combining DOX, ROS. The results indicate that 23.9% catalysis‐treated cells senesced, solid mice disappeared completely after therapy. Collectively, this study highlights novel realize utilizing significance improve

Language: Английский

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