Ferroptosis
is
a
form
of
programmed
cell
death
that
distinct
from
apoptosis.
The
mechanism
involves
redox‑active
metallic
iron
and
characterized
by
an
abnormal
increase
in
iron‑dependent
lipid
reactive
oxygen
species,
which
results
high
levels
membrane
peroxides.
relationship
between
ferroptosis
gynaecological
tumours
complex.
can
regulate
tumour
proliferation,
metastasis
chemotherapy
resistance,
targeting
promising
antitumour
approach.
interacts
with
mechanisms
related
to
tumorigenesis
development,
such
as
macrophage
polarization,
the
neutrophil
trap
network,
mitochondrial
autophagy
cuproptosis.
present
review
examines
recent
information
on
interaction
molecular
other
tumour‑related
mechanisms,
well
involvement
tumours,
identify
implications
for
cancer
therapy.
Redox Biology,
Год журнала:
2024,
Номер
75, С. 103259 - 103259
Опубликована: Июнь 27, 2024
Ferroptosis
is
a
form
of
iron-related
oxidative
cell
death
governed
by
an
integrated
redox
system,
encompassing
pro-oxidative
proteins
and
antioxidative
proteins.
These
undergo
precise
control
through
diverse
post-translational
modifications,
including
ubiquitination,
phosphorylation,
acetylation,
O-GlcNAcylation,
SUMOylation,
methylation,
N-myristoylation,
palmitoylation,
modification.
modifications
play
pivotal
roles
in
regulating
protein
stability,
activity,
localization,
interactions,
ultimately
influencing
both
the
buildup
iron
lipid
peroxidation.
In
mammalian
cells,
regulators
ferroptosis
typically
degradation
via
two
principal
pathways:
ubiquitin-proteasome
which
handles
majority
degradation,
autophagy,
primarily
targeting
long-lived
or
aggregated
This
comprehensive
review
aims
to
summarize
recent
advances
modification
linked
ferroptosis.
It
also
discusses
strategies
for
modulating
systems,
providing
new
insights
into
potential
therapeutic
applications
cancer
non-neoplastic
diseases.
Molecules,
Год журнала:
2024,
Номер
29(16), С. 3886 - 3886
Опубликована: Авг. 16, 2024
Artemisinin
is
a
natural
sesquiterpene
lactone
obtained
from
the
traditional
Chinese
medicinal
herb
Artemisia
annua
L.
(qinghao).
and
its
derivatives
share
an
unusual
endoperoxide
bridge
are
extensively
used
for
malaria
treatment
worldwide.
In
addition
to
antimalarial
activities,
artemisinin
have
been
reported
exhibit
promising
anticancer
effects
in
recent
decades.
this
review,
we
focused
on
research
progress
of
with
potential
activities.
The
pharmacological
effects,
mechanisms,
clinical
trials
cancer
therapy
were
discussed.
This
review
may
facilitate
future
exploration
as
effective
agents.
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(9)
Опубликована: Май 1, 2024
Abstract
Hypoxia
and
Ferroptosis
are
associated
with
the
malignant
behaviour
of
cervical
cancer.
Endothelial
PAS
domain‐containing
protein
1
(EPAS1)
contributes
to
progression
EPAS1
plays
important
roles
in
hypoxia
ferroptosis.
Using
GEO
dataset,
machine‐learning
algorithms
were
used
screen
for
hypoxia‐
ferroptosis‐related
genes
(HFRGs)
was
identified
as
hub
gene.
qPCR
WB
investigate
expression
normal
cancer
tissues.
The
proliferation,
invasion
migration
cells
HeLa
SiHa
cell
lines
detected
using
CCK8,
transwell
wound
healing
assays,
respectively.
Apoptosis
by
flow
cytometry.
A
dual‐luciferase
assay
analyse
MALAT1‐miR‐182‐5P‐EPAS1
mRNA
axis
core
promoter
elements
super‐enhancer.
significantly
overexpressed
could
increase
invasion,
reduce
apoptosis
cell.
According
double‐luciferase
assay,
regulated
MALAT1‐Mir‐182‐5p‐EPAS1
axis.
is
super‐enhancers.
Double‐luciferase
showed
that
super‐enhancer
E1
E3.
EPAS1,
an
HFRG,
promotes
cells.
super‐enhancers
MALAT1‐miR‐182‐5P‐
may
be
a
target
diagnosis
treatment
The
present
study
aimed
to
investigate
the
anti‑leukemic
effects
of
dihydroartemisinin
(DHA)
on
T‑cell
acute
lymphoblastic
leukemia
(T‑ALL)
cell
lines,
Jurkat
and
Molt‑4,
underlying
mechanisms.
Cell
Counting
Kit‑8
was
performed
measure
viability.
apoptosis
cycle
distribution
were
assessed
by
flow
cytometry.
expression
levels
ATF4
CHOP
mRNA
reverse
transcription‑quantitative
PCR,
while
protein
abundance
SLC7A11,
GPX4,
determined
western
blotting.
Moreover,
malondialdehyde,
glutathione
(GSH)
reactive
oxygen
species
(ROS)
assays
used
detect
ferroptosis.
results
showed
that
DHA
suppressed
T‑ALL
viability
in
vitro,
induced
arrest
at
S
or
G2/M
phase.
also
ROS
burst,
activated
endoplasmic
reticulum
(ER)
stress,
disrupted
system
Xc‑‑GSH‑GSH
peroxidase
4
antioxidant
system,
increased
lipid
peroxide
accumulation,
resulting
in
death.
By
contrast,
pharmacological
inhibition
ferroptosis
alleviated
DHA‑induced
death,
confirming
induces
death
via
Mechanistically,
effect
partly
mediated
downregulating
SLC7A11
upregulating
ATF4‑CHOP
signaling
pathway,
which
is
associated
with
ER
stress.
These
indicated
may
induce
lines
could
represent
a
promising
therapeutic
agent
for
treating
T‑ALL.
Infection Genetics and Evolution,
Год журнала:
2023,
Номер
112, С. 105460 - 105460
Опубликована: Июнь 1, 2023
Malaria
still
poses
a
major
burden
on
human
health
around
the
world,
especially
in
endemic
areas.
Plasmodium
resistance
to
several
antimalarial
drugs
has
been
one
of
hindrances
control
malaria.
Thus,
World
Health
Organization
recommended
artemisinin-based
combination
therapy
(ACT)
as
front-line
treatment
for
The
emergence
parasites
resistant
artemisinin,
along
with
ACT
partner
drugs,
led
failure.
artemisinin
is
mostly
related
mutations
propeller
domain
kelch13
(k13)
gene
that
encodes
protein
Kelch13
(K13).
K13
an
important
role
parasite
reaction
oxidative
stress.
most
widely
spread
mutation
K13,
highest
degree
resistance,
C580Y
mutation.
Other
mutations,
which
are
already
identified
markers
R539T,
I543T,
and
Y493H.
objective
this
review
provide
current
molecular
insights
into
falciparum.
trending
use
beyond
its
effect
described.
Immediate
challenges
future
research
directions
discussed.
Better
understanding
mechanisms
underlying
will
accelerate
implementation
scientific
findings
solve
problems
malarial
infection.
Frontiers in Public Health,
Год журнала:
2023,
Номер
11
Опубликована: Авг. 28, 2023
To
explore
the
positivity
rate
and
genotype
distribution
of
human
papillomavirus
(HPV)
in
cervical
squamous
cell
carcinoma
(CSCC)
tissues
central
eastern
China
to
provide
theoretical
basis
for
cancer
screening
prophylactic
HPV
vaccine
development
China.
DNA
was
extracted
from
paraffin-embedded
CSCC
samples
exfoliated
cells
populations.
23
genotypes
were
detected
by
combining
polymerase
chain
reaction
(PCR)
reverse
dot
hybridized
gene
chip
detection
technology
2,306
10,245
The
infection
analyzed.
overall
HPVs
patients
92.71%.
frequency
single-type
multiple-type
86.48%
13.51%,
respectively.
most
common
Chinese
HPV-16,
HPV-18,
HPV-31,
HPV-33,
HPV-45,
HPV-52,
HPV-58,
HPV-59.
these
eight
high-risk
(HR-HPV)
HPV-positive
as
high
96.91%.
Of
which
seven
HR-HPV
related
nine-valent
vaccines
95.09%.
Meanwhile,
rates
low-risk
(LR-HPV)
female
aged
35-64
years
who
underwent
13.16%
1.32%,
high-frequency
women
HPV-53,
HPV-68,
HPV-39,
HPV-51,
HPV-56,
with
2.25%,
1.60%,
1.31%,
1.22%,
0.93%,
0.92%,
0.78%,
0.74%,
Among
screened
China,
detecting
8
can
reduce
technical
difficulty
reagent
costs,
while
also
improving
efficiency
effectiveness
screening.
genotyping
assists
gynecologists
assessing
risk
HR-HPV-positive
intraepithelial
neoplasia
guiding
them
implementing
appropriate
interventions.
Furthermore,
is
helpful
doctors
follow
up
evaluate
protective
effect
vaccine.
