Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 19, 2025
Introduction
Colorectal
cancer
is
a
leading
cause
of
related-death
worldwide,
and
resistance
to
5-fluorouracil
(5FU,
key
component
chemotherapy
regimens,
major
clinical
concern.
We
have
previously
elucidated
the
effects
Rhus
coriaria
ethanolic
extract
(RCE)
in
triple-negative
breast
cancer,
CRC,
pancreatic
cells.
Here,
we
explored
anticancer
RCE
parental
(HCT-116-WT)
5FU-resistant
HCT-116
(HCT-116-5FU-R)
CRC
Methods
MTT
assay
was
used
assess
cell
viability.
Muse
analyzer
viability,
cycle
distribution,
apoptosis.
Additionally,
colony
formation
growth
assays
western
blots
were
performed.
In
vivo
assessed
by
an
ovo
chick
embryo
tumor
assay.
Results
found
that
inhibited
viability
capacities
HCT-116-WT
HCT-116-5FU-R
The
antiproliferative
attributed
DNA
damage-mediated
impairment
at
S
phase,
induction
Beclin-1-independent
autophagy
both
lines.
Mechanistically,
inhibition
mTOR,
STAT3
p38
MAPK
pathways
implicated
latter.
induced
caspase-7-independent
apoptosis
However,
cells
resistant
through
upregulation
survivin,
downregulation
Bax.
Using
proteasome
inhibitors,
clarified
pathway
contributed
RCE-mediated
death
Lastly,
confirmed
xenografts
model.
Discussion
Collectively,
our
findings
highlight
source
phytochemicals
can
be
as
agents
for
CRC.
Pharmaceutics,
Год журнала:
2024,
Номер
16(4), С. 569 - 569
Опубликована: Апрель 22, 2024
Overcoming
the
limited
bioavailability
and
extensive
metabolism
of
effective
in
vitro
drugs
remains
a
challenge
that
limits
translation
promising
into
clinical
trials.
Resveratrol,
despite
its
well-reported
therapeutic
benefits,
is
not
metabolically
stable
thus
has
been
utilized
as
an
drug.
This
because
it
needs
to
be
consumed
large
amounts
overcome
burdens
conversion
less
metabolites.
Herein,
we
summarize
more
relevant
approaches
modify
resveratrol,
aiming
increase
biological
efficacy.
We
discuss
combination
therapies,
derivatization,
use
resveratrol
nanoparticles.
Interestingly,
with
established
chemotherapeutic
shown
effects
on
colon
cancer
(with
oxaliplatin),
liver
cisplatin,
5-FU),
gastric
doxorubicin).
On
other
hand,
derivatizing
including
hydroxylation,
amination,
amidation,
imidation,
methoxylation,
prenylation,
halogenation,
glycosylation,
oligomerization,
differentially
modifies
could
used
for
preferential
outcomes.
Moreover,
encapsulation
allows
trapping
within
different
forms
shells
targeted
therapy.
Depending
nanoparticle
used,
can
enhance
solubility
absorption,
increasing
These
include
polymers,
metals,
solid
lipids,
nanoparticles
have
preclinical
results,
adding
“hype”
research
resveratrol.
review
provides
platform
compare
allow
directed
better
treatment
options
Food Reviews International,
Год журнала:
2025,
Номер
unknown, С. 1 - 50
Опубликована: Янв. 4, 2025
Cancer
is
the
world's
second
most
common
cause
of
death,
with
colon
cancer
(CC)
ranking
third
in
prevalence
and
cancer-related
fatalities.
CC
originates
or
rectum
influenced
by
genetic
mutations,
lifestyle,
diet.
Although
chemotherapy,
especially
5-fluorouracil
(5-FU),
fundamental
to
treatment
has
improved
patient
survival,
its
benefits
are
often
limited
significant
side
effects
emerging
drug
resistance.
Recently,
plant-based
foods
have
drawn
interest
research
for
their
natural
bioactive
compounds
relatively
low
toxicity.
Certain
plant
not
only
exhibit
anti-cancer
activity
but
may
also
boost
effectiveness
5-FU
while
reducing
adverse
effects.
Despite
evidence
suggesting
a
synergistic
effect
between
5-FU,
this
area
remains
fragmented.
This
review
consolidates
current
on
including
fruits,
vegetables,
legumes,
tea
bioactives
treatment.
Besides,
it
explores
mechanisms
through
which
these
enhance
efficacy
reduce
effects,
evaluates
clinical
application
prospects,
identifies
challenges
future
directions.
comprehensive
analysis
aims
provide
scientific
foundation
integrated
CC,
highlighting
potential
enhancing
chemotherapy
associated
toxicities.
Biomedicines,
Год журнала:
2023,
Номер
11(1), С. 208 - 208
Опубликована: Янв. 14, 2023
Drug
resistance
is
a
major
problem
in
cancer
treatment,
as
it
limits
the
effectiveness
of
pharmacological
agents
and
can
lead
to
disease
progression.
Cold
atmospheric
plasma
(CAP)
technology
that
uses
ionized
gas
(plasma)
generate
reactive
oxygen
nitrogen
species
(RONS)
kill
cells.
CAP
novel
approach
for
overcoming
drug
cancer.
In
recent
years,
there
has
been
growing
interest
using
enhance
chemotherapy
drugs.
this
review,
we
discuss
mechanisms
behind
phenomenon
explore
its
potential
applications
treatment.
Going
through
existing
literature
on
cancer,
highlight
challenges
opportunities
further
research
field.
Our
review
suggests
could
be
promising
option
warrants
investigation.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Сен. 19, 2023
A
large
body
of
evidence
indicates
the
existence
a
complex
pathophysiological
relationship
between
cardiovascular
diseases
and
cancer.
Mitochondria
are
crucial
organelles
whose
optimal
activity
is
determined
by
quality
control
systems,
which
regulate
critical
cellular
events,
ranging
from
intermediary
metabolism
calcium
signaling
to
mitochondrial
dynamics,
cell
death
mitophagy.
Emerging
data
indicate
that
impaired
drives
myocardial
dysfunction
occurring
in
several
heart
diseases,
including
cardiac
hypertrophy,
infarction,
ischaemia/reperfusion
damage
metabolic
cardiomyopathies.
On
other
hand,
diverse
human
cancers
also
dysregulate
promote
their
initiation
progression,
suggesting
modulating
homeostasis
may
represent
promising
therapeutic
strategy
both
cardiology
oncology.
In
this
review,
first
we
briefly
introduce
physiological
mechanisms
underlying
system,
then
summarize
current
understanding
about
impact
dysregulated
functions
We
discuss
key
increased
risk
complications
secondary
main
anticancer
strategies,
highlighting
potential
strategies
aimed
at
alleviating
impairment-related
tumorigenesis.
It
hoped
summary
can
provide
novel
insights
into
precision
medicine
approaches
reduce
cancer
morbidities
mortalities.
Cancer Drug Resistance,
Год журнала:
2023,
Номер
6(2), С. 257 - 272
Опубликована: Янв. 1, 2023
The
emergence
of
chemoresistant
disease
during
chemotherapy
with
5-Fluorouracil-based
(5-FU-based)
regimens
is
an
important
factor
in
the
mortality
metastatic
CRC
(mCRC).
causes
5-FU
resistance
are
multi-factorial,
and
besides
DNA
mismatch
repair
deficiency
(MMR-D),
there
no
widely
accepted
criteria
for
determining
which
patients
not
likely
to
be
responsive
5-FU-based
therapy.
Thus,
a
need
systematically
understand
mechanistic
basis
treatment
failure
urgent
develop
new
approaches
circumventing
major
resistance.
In
this
manuscript,
we
review
mechanisms
emphasis
on:
(1)
altered
anabolic
metabolism
limiting
formation
primary
active
metabolite
Fluorodeoxyuridylate
(5-Fluoro-2'-deoxyuridine-5'-O-monophosphate;
FdUMP);
(2)
elevated
expression
or
activity
enzymatic
target
thymidylate
synthase
(TS);
(3)
dysregulated
programmed
cell
death
as
Importantly,
these
can
potentially
overcome
through
use
next-generation
fluoropyrimidine
(FP)
polymers
(e.g.,
CF10)
that
display
reduced
dependence
on
more
potent
TS
inhibitory
activity.
