Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(11), P. 1136 - 1136
Published: Nov. 11, 2024
Endoplasmic
reticulum
(ER)
stress
is
a
state
in
which
misfolded
or
unfolded
proteins
accumulate
the
lumen
of
ER
as
result
some
exogenous
endogenous
factors.
It
plays
crucial
role
pathogenesis
malignancies,
affecting
cell
survival,
proliferation,
and
metastasis
cancer.
genes
could
provide
new
ideas
for
potential
therapeutic
targets
In
our
study,
we
aimed
to
construct
an
stress-related
(ERGs)
model
hepatocellular
carcinoma
(HCC).
ERGs
with
differential
expression
significant
survival
were
screened
prognostic
model.
The
effectiveness
was
successfully
validated
by
external
datasets.
High
low-risk
groups
classified
based
on
risk
scores.
Functional
analysis
showed
involved
protein
response,
DNA
repair,
other
pathways.
When
compared
patients
low
risk,
prognosis
HCC
high-risk
group
might
be
worsened
disruptions
these
Importantly,
considered
genomic
druggability
predicted
drugs.
Sorafenib-induced
autophagy
cells
through
ES
mechanism.
Sorafenib
more
sensitive
patients.
brief,
provided
novel
treatment
strategies
study
cancers.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
The
crosstalk
between
immunity
and
cancer
in
the
regulation
of
tumor
growth
is
considered
a
hallmark
cancer.
Antitumor
refers
to
innate
adaptive
immune
responses
that
regulate
development
proliferation.
Tumor
evasion
represents
major
hindrance
effective
anticancer
treatment.
Extracellular
vesicles
(EVs)
are
nano-sized
lipid-bilayer-enclosed
particles
secreted
extracellular
space
by
all
cell
types.
They
critically
involved
numerous
biological
functions
including
intercellular
communication.
Tumor-derived
(TEVs)
can
transport
variety
cargo
modulate
cells
microenvironment
(TME).
This
review
provides
latest
update
about
how
evade
surveillance
exploiting
TEVs.
First,
biogenesis
EVs
cargo-sorting
machinery
discussed.
Second,
differentiation,
activation,
function
via
TEVs
illustrated.
Last
but
not
least,
novel
antitumor
strategies
reverse
escape
summarized.
iScience,
Journal Year:
2024,
Volume and Issue:
27(4), P. 109350 - 109350
Published: Feb. 27, 2024
Colorectal
cancer
(CRC)
ranks
as
the
second
leading
cause
of
cancer-related
mortality,
with
metastasis
being
primary
determinant
poor
prognosis
in
patients.
Investigating
molecular
mechanisms
underlying
CRC
is
currently
a
prominent
and
challenging
area
research.
Exosomes,
crucial
intercellular
communication
mediators,
facilitate
transfer
metabolic
genetic
information
from
cells
origin
to
recipient
cells.
Their
roles
mediating
exchange
between
immune
cells,
fibroblasts,
other
cell
types
are
pivotal
reshaping
tumor
microenvironment,
regulating
key
biological
processes
such
invasion,
migration,
formation
pre-metastatic
niche.
This
article
comprehensively
examines
function
mechanism
exosomes
derived
different
metastasis,
while
also
presenting
an
outlook
on
current
research
advancements
future
application
prospects.
The
aim
offer
distinctive
perspective
that
contributes
accurate
diagnosis
rational
treatment
strategies
for
CRC.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3415 - 3415
Published: March 18, 2024
Glioblastoma
multiforme
(GBM)
is
a
malignancy
of
bad
prognosis,
and
advances
in
early
detection
treatment
are
needed.
GBM
heterogenous,
with
varieties
differing
within
tumor
patient
between
patients.
Means
needed
to
distinguish
these
GMB
forms,
so
that
specific
strategies
can
be
deployed
for
management.
We
study
the
participation
chaperone
system
(CS)
carcinogenesis.
The
CS
dynamic,
its
members
moving
around
body
extracellular
vesicles
(EVs)
interacting
components
other
physiological
systems
health
disease,
including
GBM.
Here,
we
describe
finding
high
amounts
Hsp70
(HSPA1A)
calcitonin
receptor
protein
(CTR)
EVs
patients
present
standardized
protocol
collecting,
purifying,
characterizing
carrying
CTR
plasma-derived
from
were
obtained
just
before
ablative
surgery
(T0)
7
days
afterwards
(T1);
was
highly
elevated
at
T0
less
T1,
greatly
increased
reduced
below
normal
values
T1.
Our
results
encourage
further
research
assess
as
biomarkers
differentiating
forms
determine
their
roles
Cancers,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2574 - 2574
Published: July 18, 2024
Extracellular
vesicles,
or
EVs,
are
membrane-bound
nanocompartments
produced
by
tumor
cells.
EVs
carry
proteins
and
nucleic
acids
from
host
cells
to
target
cells,
where
they
can
transfer
lipids,
proteomes,
genetic
material
change
the
function
of
serve
as
reservoirs
for
mobile
cellular
signals.
The
collection
using
less
invasive
processes
has
piqued
interest
many
researchers.
Exosomes
substances
that
suppress
immune
system.
If
results
exosome
screening
negative,
immunotherapy
will
be
beneficial
GC
patients.
In
this
study,
we
provide
an
update
on
based
ongoing
review
papers
clinical
trials.
Life,
Journal Year:
2024,
Volume and Issue:
14(3), P. 408 - 408
Published: March 20, 2024
Extracellular
vesicles
(EVs)
released
from
primary
cell
lines,
originating
resected
tissues
during
biopsies
in
patients
with
non-small
lung
cancer
(NSCLC)
revealing
adenocarcinoma
and
squamous
carcinoma
subtypes,
were
examined
for
membrane
proteomic
fingerprints
using
a
proximity
barcoding
assay.
All
the
collected
EVs
expressed
canonical
tetraspanins
(CD9,
CD63,
CD81)
highly
coexpressed
molecules
such
as
lysosome-associated
protein-1
(LAMP1-CD107a),
sialomucin
core
protein
24
(CD164),
Raph
blood
group
(CD151),
integrins
(ITGB1
ITGA2).
This
representation
of
on
EV
surface
may
provide
valuable
information
NSCLC
subtypes
offer
new
diagnostic
opportunities
next-generation
biomarkers
personalized
oncology.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1599 - 1599
Published: Dec. 14, 2024
Extracellular
vesicles
(EVs)
are
lipid
bilayer
nanoparticles
released
from
all
known
cells
and
involved
in
cell-to-cell
communication
via
their
molecular
content.
EVs
have
been
found
tissues
body
fluids,
carrying
a
variety
of
biomolecules,
including
DNA,
RNA,
proteins,
metabolites,
lipids,
offering
insights
into
cellular
pathophysiological
conditions.
Despite
the
emergence
contents
as
important
biological
indicators,
it
remains
difficult
to
explore
EV-mediated
processes
due
small
size
heterogeneity
technical
challenges
characterizing
EV-associated
RNAs,
especially
microRNAs,
extensively
studied.
However,
other
less
characterized
protein-coding
mRNAs,
long
noncoding
circular
tRNAs,
also
EVs.
Furthermore,
proteins
can
be
used
distinguish
different
types
The
spectrum
well
may
associated
with
Therefore,
ability
comprehensively
characterize
EVs’
content
is
critical
for
understanding
function
potential
applications
disease
diagnosis.
Here,
we
set
out
provide
an
overview
RNAs
approaches
currently
being
them.
