Inorganic nanomaterials with rapid clearance for biomedical applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742

Published: Jan. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Language: Английский

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Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 2, 2020

Abstract The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy against malignant tumors. Nanomaterial‐based photothermal (PTT) and magnetic (MHT), highly effective noninvasive treatment models, offer advantages over other strategies in the of different types However, both PTT MHT cannot completely cure cancer due to recurrence distal metastasis. In recent years, immunotherapy has attracted widespread attention owing its capability activate body's own natural defense identify, attack, eradicate cells. Significant efforts been devoted studying activated immune responses caused by hyperthermia‐ablated this article, synergistic mechanism HTT immunotherapy, including immunogenic cell death reversal immunosuppressive tumor microenvironment is discussed. reports combination or HTT‐based multimodal with immunoadjuvant exploitation, checkpoint blockade therapy, adoptive cellular are summarized. As highlighted, these could achieve synergistically enhanced therapeutic outcomes primary tumors metastatic lesions, prevent recurrence, prolong survival period. Finally, current challenges prospective developments HTT‐synergized also reviewed.

Language: Английский

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Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

Advanced Science, Journal Year: 2018, Volume and Issue: 5(5)

Published: March 3, 2018

Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated thermosensitive hydrogel [poly(d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide) (PDLLA-PEG-PDLLA: PLEL)] to produce new system postoperative cancer. The BP@PLEL exhibits excellent near infrared (NIR) photothermal performance rapid NIR-induced sol-gel transition well good biocompatibility in vitro vivo. Based on these merits, vivo established. Under NIR irradiation, sprayed enables gelation forming gelled membrane wounds offers high efficacy eliminate residual tumor tissues after removal surgery. Furthermore, antibacterial prevents infection this biodegradable very promising

Language: Английский

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Enhancing Both Biodegradability and Efficacy of Semiconducting Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy

ACS Nano, Journal Year: 2018, Volume and Issue: 12(2), P. 1801 - 1810

Published: Jan. 31, 2018

Theranostic nanoagents are promising for precision medicine. However, biodegradable with the ability photoacoustic (PA) imaging guided photothermal therapy (PTT) rare. We herein report development of semiconducting polymer nanoparticles (SPNs) enhanced PA and PTT efficacy cancer therapy. The design capitalizes on enzymatically oxidizable nature vinylene bonds in conjunction chemistry to synthesize a (DPPV) transform it into water-soluble (SPNV). As compared its counterpart SPN (SPNT), presence within backbone also endows SPNV significantly mass absorption coefficient (1.3-fold) conversion (2.4-fold). such, provides signals maximum temperature higher than SPNT, allowing detection ablation tumors living mice more sensitive effective way. Our study thus reveals general molecular enhance biodegradability optically active while dramatically elevating their therapeutic capabilities.

Language: Английский

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X-ray-activated nanosystems for theranostic applications

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(11), P. 3073 - 3101

Published: Jan. 1, 2019

X-rays are widely applied in clinical medical facilities for radiotherapy (RT) and biomedical imaging. However, the sole use of cancer treatment leads to insufficient radiation energy deposition due low X-ray attenuation coefficients living tissues organs, producing unavoidable excessive doses with serious side effects healthy body parts. Over past decade, developments materials science nanotechnology have led rapid progress field X-ray-activated tumor-targeting nanosystems, which able tackle even systemic tumors relieve burden exposure large doses. Additionally, novel imaging contrast agents techniques also been developed. In comparison conventional external light sources (e.g., near infrared), technique is ideal activation nanosystems applications its nearly unlimited penetration depth organisms. this review, we systematically describe interaction mechanisms between provide an overview X-ray-sensitive recent on cancer-associated theranostic applications.

Language: Английский

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Iron Oxide Nanoparticles in Photothermal Therapy

Molecules, Journal Year: 2018, Volume and Issue: 23(7), P. 1567 - 1567

Published: June 28, 2018

Photothermal therapy is a kind of based on increasing the temperature tumoral cells above 42 °C. To this aim, must be illuminated with laser, and energy radiation transformed in heat. Usually, employed belongs to near-infrared range. At range, absorption scattering by body minimal. Thus, tissues are almost transparent. improve efficacy selectivity energy-to-heat transduction, light-absorbing material, photothermal agent, introduced into tumor. present, vast array compounds available as agents. Among substances used agents, gold-based one most employed. However, undefined toxicity metal hinders their clinical investigations long run. Magnetic nanoparticles good alternative for use agent treatment tumors. Such nanoparticles, especially those formed iron oxides, can combination other or themselves The magnetic agents adds more capabilities therapeutic system: directed magnetically site interest (the tumor) distribution tumors organs imaged. When alone, theory, an important limitation: molar coefficient near infrared region low. controlled clustering solve drawback. In such conditions, indicated higher conversion heat efficient than individual nanoparticles. On hand, it designed system, which generated after irradiation light release drug attached manner. This form targeted delivery seems promising tool chemo-phototherapy. Finally, heating efficiency oxide increased if combined alternating field.

Language: Английский

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Recent Advances in Glucose‐Oxidase‐Based Nanocomposites for Tumor Therapy

Small, Journal Year: 2019, Volume and Issue: 15(51)

Published: Nov. 20, 2019

Abstract Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O 2 ) to produce hydrogen peroxide (H O gluconic acid, which cut off the nutrition source of cancer cells consequently inhibit their proliferation. Therefore, GOx is recognised as an ideal endogenous oxido‐reductase for starvation therapy. This process further regulate tumor microenvironment by increasing hypoxia acidity. Thus, offers new possibilities elaborate design multifunctional nanocomposites However, natural expensive prepare purify exhibits immunogenicity, short in vivo half‐life, systemic toxicity. Furthermore, highly prone degrade after exposure biological conditions. These intrinsic shortcomings will undoubtedly limit its biomedical applications. Accordingly, some nanocarriers be used protect from surrounding environment, thus controlling or preserving activity. A variety including hollow mesoporous silica nanoparticles, metal–organic frameworks, organic polymers, magnetic nanoparticles are summarized construction GOx‐based multimodal synergistic In addition, current challenges promising developments this area highlighted.

Language: Английский

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Boosting H₂O₂‐Guided Chemodynamic Therapy of Cancer by Enhancing Reaction Kinetics through Versatile Biomimetic Fenton Nanocatalysts and the Second Near‐Infrared Light Irradiation

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 30(3)

Published: Nov. 4, 2019

Abstract Fenton reaction–based chemodynamic therapy (CDT) has attracted considerable attention for tumor treatment, because the reaction can degrade endogenous H 2 O within to form reactive oxygen species (ROS) kill cancer cells. The kinetics of significantly influenced its treatment efficacy. It is crucial enhance at maximum concentration quickly produce vast amounts ROS achieve efficacy, which date, not been realized. Herein, reported an efficacious CDT breast using biomimetic CS‐GOD@CM nanocatalysts, are rationally designed boost through improvement tumors, and application second near‐infrared (NIR‐II) light irradiation concentration, monitored by photoacoustic imaging. nanocatalysts composed ultra‐small Cu 2− x Se (CS) nanoparticles, glucose oxidase (GOD), cell membrane (CM). be retained in more than two days oxidize approximately 2.6‐fold increase under NIR‐II irradiation. This work demonstrates first time enhanced light.

Language: Английский

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BSA‐IrO₂: Catalase‐like Nanoparticles with High Photothermal Conversion Efficiency and a High X‐ray Absorption Coefficient for Anti‐inflammation and Antitumor Theranostics

Angewandte Chemie International Edition, Journal Year: 2018, Volume and Issue: 57(32), P. 10309 - 10313

Published: June 11, 2018

Intrinsically integrating precise diagnosis, effective therapy, and self-anti-inflammatory action into a single nanoparticle is attractive for tumor treatment future clinical application, but still remains great challenge. In this study, bovine serum albumin-iridium oxide nanoparticles (BSA-IrO2 NPs) with extraordinary photothermal conversion efficiency, good photocatalytic activity, high X-ray absorption coefficient were prepared through one-step biomineralization. The allow phototherapy simultaneous photoacoustic/thermal imaging computed tomography. More importantly, BSA-IrO2 NPs can also act as catalase to protect normal cells against H2 O2 -induced reactive oxygen pressure inflammation while significantly enhancing photoacoustic microbubble-based inertial cavitation. These remarkable features may open up the exploration iridium-based nanomaterials in theranostics.

Language: Английский

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NIR‐II Responsive Inorganic 2D Nanomaterials for Cancer Photothermal Therapy: Recent Advances and Future Challenges

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(32)

Published: June 10, 2021

Abstract Non‐invasive cancer photothermal therapy (PTT) is a promising replacement for traditional treatments. The second near‐infrared region induced PTT (NIR‐II PTT, 1000–1500 nm) with less energy dissipation has been developed deeper‐seated tumor treatment in recent years compared the first light (750–1000 nm). In addition, use of emerging inorganic 2D nanomaterials as agents (PTAs) further enhanced efficiency due to their intrinsic properties. NIR‐II stimulated becoming hot topic both academic and clinical fields. This review summarizes categories, structures, conversion properties time. synergistic strategies responsive combined other approaches including chemotherapy, chemodynamic therapy, photodynamic radiotherapy are summarized. future challenges perspectives on these systems construction discussed.

Language: Английский

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