Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes DOI Creative Commons

Maurizio Gulino,

Dong‐Hoon Kim, Salvador Pané

et al.

Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: July 5, 2019

The development of implantable neuroelectrodes is advancing rapidly as these tools are becoming increasingly ubiquitous in clinical practice, especially for the treatment traumatic and neurodegenerative disorders. Electrodes have been exploited a wide number neural interface devices, such deep brain stimulation, which one most successful therapies with proven efficacy diseases like Parkinson or epilepsy. However, main caveats related to application electrodes nervous tissue response at injury site, characterized by cascade inflammatory events, culminate chronic inflammation, and, turn, result failure implant over extended periods time. To overcome current limitations widespread macroelectrode based systems, new design strategies innovative materials superior biocompatibility characteristics currently being investigated. This review describes state art vitro, ex vivo models available study microelectrodes. We particularly highlight increased complexity that closely mimic scenarios can serve promising alternatives animal studies investigation microelectrodes tissues. Additionally, we also express our view on impact progress field engineering research.

Language: Английский

Hydrogel bioelectronics DOI Creative Commons

Hyunwoo Yuk,

Baoyang Lu,

Xuanhe Zhao

et al.

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(6), P. 1642 - 1667

Published: Nov. 26, 2018

Hydrogels have emerged as a promising bioelectronic interfacing material. This review discusses the fundamentals and recent advances in hydrogel bioelectronics.

Language: Английский

Citations

1642

Glial responses to implanted electrodes in the brain DOI
Joseph W. Salatino, Kip A. Ludwig, Takashi D.Y. Kozai

et al.

Nature Biomedical Engineering, Journal Year: 2017, Volume and Issue: 1(11), P. 862 - 877

Published: Nov. 3, 2017

Language: Английский

Citations

510

Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics DOI
Wenzheng Heng,

Samuel A. Solomon,

Wei Gao

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(16)

Published: Dec. 12, 2021

Abstract Medical robots are invaluable players in non‐pharmaceutical treatment of disabilities. Particularly, using prosthetic and rehabilitation devices with human–machine interfaces can greatly improve the quality life for impaired patients. In recent years, flexible electronic soft robotics have attracted tremendous attention this field due to their high biocompatibility, functionality, conformability, low‐cost. Flexible on will make a promising alternative conventional rigid devices, which potentially revolutionize paradigm future direction medical terms feedback user experience. review, fundamental components materials, structures, mechanisms human‐machine summarized by renowned applications five primary areas: physical chemical sensing, physiological recording, information processing communication, robotic actuation, stimulation. This review further concludes discussing outlook current challenges these technologies as interface robotics.

Language: Английский

Citations

375

Materials for flexible bioelectronic systems as chronic neural interfaces DOI
Enming Song, Jinghua Li, Sang Min Won

et al.

Nature Materials, Journal Year: 2020, Volume and Issue: 19(6), P. 590 - 603

Published: May 27, 2020

Language: Английский

Citations

371

Wireless and battery-free technologies for neuroengineering DOI Open Access
Sang Min Won, Le Cai, Philipp Gutruf

et al.

Nature Biomedical Engineering, Journal Year: 2021, Volume and Issue: 7(4), P. 405 - 423

Published: March 8, 2021

Language: Английский

Citations

255

Beyond solid-state lighting: Miniaturization, hybrid integration, and applications of GaN nano- and micro-LEDs DOI Creative Commons
Hutomo Suryo Wasisto, Joan Daniel Prades, Jan Gülink

et al.

Applied Physics Reviews, Journal Year: 2019, Volume and Issue: 6(4)

Published: Dec. 1, 2019

Gallium nitride (GaN) light-emitting-diode (LED) technology has been the revolution in modern lighting. In last decade, a huge global market of efficient, long-lasting, and ubiquitous white light sources developed around inception Nobel-prize-winning blue GaN LEDs. Today, optoelectronics is developing beyond solid-state lighting, leading to new innovative devices, e.g., for microdisplays, being core future augmented reality visualization, as well point optical excitation communications, imaging, sensing. This explosion applications driven by two main directions: ability produce very small LEDs (micro-LEDs nano-LEDs) with high efficiency across large areas, combination possibility merge optoelectronic-grade micro-LEDs silicon microelectronics hybrid approach. LED now even spreading into realm display technology, which occupied organic liquid crystal displays decades. this review, technological transition toward micro- nanodevices lighting discussed including an up-to-date overview on state art.

Language: Английский

Citations

251

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials DOI
Donghui Zhang, Qi Chen, Chao Shi

et al.

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 31(6)

Published: Oct. 23, 2020

Abstract Foreign‐body response caused by implanted biomaterials seriously impedes the function of implants and is a major obstacle to development implantable medical devices. Recent advances in devices have provided strategies resist foreign‐body response. In this review, mechanism conventional mitigate briefly introduced. Then, three types promising resisting materials are focused advantages, characteristics, applications each material discussed. Finally, prospects put forward for future current challenges that require in‐depth study.

Language: Английский

Citations

230

Emerging Modalities and Implantable Technologies for Neuromodulation DOI Creative Commons
Sang Min Won, Enming Song, Jonathan T. Reeder

et al.

Cell, Journal Year: 2020, Volume and Issue: 181(1), P. 115 - 135

Published: March 26, 2020

Language: Английский

Citations

217

Recent Advances in Materials, Devices, and Systems for Neural Interfaces DOI
Sang Min Won, Enming Song, Jianing Zhao

et al.

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(30)

Published: May 31, 2018

Abstract Technologies capable of establishing intimate, long‐lived optical/electrical interfaces to neural systems will play critical roles in neuroscience research and the development nonpharmacological treatments for neurological disorders. The high‐density 3D populations neurons across entire tissue living animals, including human subjects, represents a grand challenge field, where advanced biocompatible materials engineered structures electrodes light emitters be essential. This review summarizes recent progress these directions, with an emphasis on most promising demonstrated concepts, materials, devices, systems. article begins overview electrode enhanced electrical and/or mechanical performance, forms ranging from planar films, micro/nanostructured surfaces, porous frameworks soft composites. Subsequent sections highlight integration active components multiplexed addressing, local amplification, wireless data transmission, power harvesting, multimodal operation soft, shape‐conformal These advances establish foundations scalable architectures future, blurring lines between biotic abiotic catalyze profound health/well‐being.

Language: Английский

Citations

176

Interface-engineered atomically thin Ni3S2/MnO2 heterogeneous nanoarrays for efficient overall water splitting in alkaline media DOI
Ye Xiong, Lulu Xu, Chunde Jin

et al.

Applied Catalysis B Environment and Energy, Journal Year: 2019, Volume and Issue: 254, P. 329 - 338

Published: May 3, 2019

Language: Английский

Citations

163