Zwitterionic Biomaterials

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(23), P. 17073 - 17154

Published: Oct. 6, 2022

The term "zwitterionic polymers" refers to polymers that bear a pair of oppositely charged groups in their repeating units. When these are equally distributed at the molecular level, molecules exhibit an overall neutral charge with strong hydration effect via ionic solvation. constitutes foundation series exceptional properties zwitterionic materials, including resistance protein adsorption, lubrication interfaces, promotion stabilities, antifreezing solutions, etc. As result, materials have drawn great attention biomedical and engineering applications recent years. In this review, we give comprehensive panoramic overview covering fundamentals nonfouling behaviors, different types surfaces polymers, applications.

Language: Английский

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Hydrogel interfaces for merging humans and machines

Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(12), P. 935 - 952

Published: Oct. 13, 2022

Language: Английский

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Device integration of electrochemical biosensors

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(5), P. 346 - 360

Published: Feb. 24, 2023

Language: Английский

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Soft Bioelectronics Based on Nanomaterials

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(5), P. 5068 - 5143

Published: Dec. 28, 2021

Recent advances in nanostructured materials and unconventional device designs have transformed the bioelectronics from a rigid bulky form into soft ultrathin brought enormous advantages to bioelectronics. For example, mechanical deformability of thus its conformal contact onto curved organs such as brain, heart, skin allowed researchers measure high-quality biosignals, deliver real-time feedback treatments, lower long-term side-effects vivo. Here, we review various materials, fabrication methods, strategies for flexible stretchable electronics, especially focusing on biointegrated electronics using nanomaterials their composites. First, summarize top-down material processing bottom-up synthesis methods nanomaterials. Next, discuss state-of-the-art technologies intrinsically nanocomposites composed incorporated elastomers or hydrogels. We also briefly design Then individual components bioelectronics, biosensing, data storage, display, therapeutic stimulation, power supply devices, are introduced. Afterward, representative application examples described. A brief summary with discussion remaining challenges concludes review.

Language: Английский

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Immunopolarization-regulated 3D printed-electrospun fibrous scaffolds for bone regeneration

Biomaterials, Journal Year: 2021, Volume and Issue: 276, P. 121037 - 121037

Published: July 23, 2021

Language: Английский

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Current trends in the detection and removal of heavy metal ions using functional materials

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(17), P. 5827 - 5860

Published: Jan. 1, 2023

The shortage of freshwater resources caused by heavy metal pollution is an acute global issue, which has a great impact on environmental protection and human health. Therefore, the exploitation new strategies for designing synthesizing green, efficient, economical materials detection removal ions crucial. Among various methods ions, advanced functional systems including nanomaterials, polymers, porous materials, biomaterials have attracted considerable attention over past several years due to their capabilities real-time detection, excellent efficiency, anti-interference, quick response, high selectivity, low limit detection. In this tutorial review, we review general design principles underlying aforementioned in particular highlight fundamental mechanisms specific examples detecting removing ions. Additionally, enhance water purification quality using these been reviewed, also current challenges opportunities exciting field highlighted, fabrication, subsequent treatment, potential future applications such materials. We envision that will provide invaluable guidance tailored towards metals, thereby expediting development high-performance fostering more efficient approaches remediation.

Language: Английский

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Immunomodulatory bioactive glasses for tissue regeneration

Acta Biomaterialia, Journal Year: 2021, Volume and Issue: 133, P. 168 - 186

Published: Aug. 18, 2021

The regulatory functions of the immune response in tissue healing, repair, and regeneration have been evidenced last decade. Immune cells play central roles responses toward inducing favorable regenerative processes. Modulating controlling cell (particularly macrophages) is an emerging approach to enhance regeneration. Bioactive glasses (BGs) are multifunctional materials exhibiting osteogenic, angiogenic, antibacterial properties, being increasingly investigated for various scenarios, including bone wound healing. On other hand, immunomodulatory effects BGs relation regenerating tissues started be understood, key knowledge emerging. This first review article summarizing repair firstly introduced, discussing potential mechanisms regarding immunomodulation induced by BGs. Moreover, interactions between involved process (dissolution products) summarized detail. Particularly, a well-regulated timely switch macrophage phenotype from pro-inflammatory anti-inflammatory crucial constructive through modulating osteogenesis, osteoclastogenesis, angiogenesis. influence BG characteristics on discussed. We highlight strategies employed harness enhanced regeneration, incorporation active ions, surface functionalization, controlled release molecules. Finally, we conclude with our perspectives future research challenges directions field Immunomodulatory bioactive healing understood. summarize those studies which focused introduce Interactions processes (and their dissolution products, biologically ions) elaborated. modulate enhancing agents. outlining anticipate that increasing efforts will start emerge area

Language: Английский

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Design the molecule structures to achieve functional advantages of hydrogel wound dressings: Advances and strategies

Composites Part B Engineering, Journal Year: 2022, Volume and Issue: 247, P. 110313 - 110313

Published: Oct. 4, 2022

Language: Английский

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A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions

Bioactive Materials, Journal Year: 2022, Volume and Issue: 14, P. 364 - 376

Published: Feb. 1, 2022

Polyetheretherketone (PEEK) is a desirable alternative to conventional biomedical metals for orthopedic implants due the excellent mechanical properties. However, inherent bioinertness of PEEK contributes inferior osseointegration implants, especially under pathological conditions osteoporosis. Herein, programmed surface designed and fabricated on dictate osteoimmunomodulation bone regeneration sequentially. A degradable hybrid coating consisting poly(lactide-co-glycolide) alendronate (ALN) loaded nano-hydroxyapatite deposited then interleukin-4 (IL-4) grafted onto outer with aid N2 plasma immersion ion implantation subsequent in IL-4 solution. Dominant release together ALN Ca2+ during first few days synergistically mitigates early acute inflammatory reactions creates an osteoimmunomodulatory microenvironment that facilitates regeneration. Afterwards, slow sustained delivery following weeks boosts osteogenesis suppresses osteoclastogenesis simultaneously, consequently ameliorating bone-implant even osteoporotic conditions. By taking into account different phases repair, this strategy constructing advanced sequential functions provides customizable clinically viable therapy patients.

Language: Английский

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Bionic artificial skin with a fully implantable wireless tactile sensory system for wound healing and restoring skin tactile function

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 2, 2024

Abstract Tactile function is essential for human life as it enables us to recognize texture and respond external stimuli, including potential threats with sharp objects that may result in punctures or lacerations. Severe skin damage caused by severe burns, cancer, chemical accidents, industrial accidents the structure of tissue well nerve system, resulting permanent tactile sensory dysfunction, which significantly impacts an individual’s daily life. Here, we introduce a fully-implantable wireless powered system embedded artificial (WTSA), stable operation, restore permanently damaged promote wound healing regenerating severely skin. The fabricated WTSA facilitates (i) replacement broad biocompatibility, (ii) promoting regeneration through collagen fibrin-based (CFAS), (iii) minimization foreign body reaction via hydrogel coating on neural interface electrodes. Furthermore, shows operation evidenced quantitative analysis leg movement angle electromyogram (EMG) signals response varying intensities applied pressures.

Language: Английский

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