Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Feb. 22, 2024
Abstract
Wet-tissue
adhesives
have
long
been
attractive
materials
for
realizing
complicated
biomedical
functions.
However,
the
hydration
film
on
wet
tissues
can
generate
a
boundary,
forming
hydrogen
bonds
with
that
weaken
adhesive
strength.
Introducing
black
phosphorus
(BP)
is
believed
to
enhance
water
absorption
capacity
of
tape-type
and
effectively
eliminate
layers
between
tissue
adhesive.
This
study
reports
composite
patch
integrated
BP
nanosheets
(CPB)
wet-tissue
adhesion.
The
patch’s
improved
mechanical
properties
ensure
its
immediate
robust
adhesion
tissues.
Various
bioapplications
CPB
are
demonstrated,
such
as
rapid
hemostasis
(within
~1-2
seconds),
monitoring
physical-activity
prevention
tumour-recurrence,
all
validated
via
in
vivo
studies.
Given
good
practicability,
histocompatibility
biodegradability
CPB,
proposed
patches
hold
significant
promise
wide
range
applications.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: May 25, 2023
Abstract
Blood–brain
barrier
(BBB)
is
a
natural
protective
membrane
that
prevents
central
nervous
system
(CNS)
from
toxins
and
pathogens
in
blood.
However,
the
presence
of
BBB
complicates
pharmacotherapy
for
CNS
disorders
as
most
chemical
drugs
biopharmaceuticals
have
been
impeded
to
enter
brain.
Insufficient
drug
delivery
into
brain
leads
low
therapeutic
efficacy
well
aggravated
side
effects
due
accumulation
other
organs
tissues.
Recent
breakthrough
materials
science
nanotechnology
provides
library
advanced
with
customized
structure
property
serving
powerful
toolkit
targeted
delivery.
In-depth
research
field
anatomical
pathological
study
on
further
facilitates
development
brain-targeted
strategies
enhanced
crossing.
In
this
review,
physiological
different
cells
contributing
are
summarized.
Various
emerging
permeability
regulation
crossing
including
passive
transcytosis,
intranasal
administration,
ligands
conjugation,
coating,
stimuli-triggered
disruption,
overcome
obstacle
highlighted.
Versatile
systems
ranging
organic,
inorganic,
biologics-derived
their
synthesis
procedures
unique
physio-chemical
properties
summarized
analyzed.
This
review
aims
provide
an
up-to-date
comprehensive
guideline
researchers
diverse
fields,
offering
perspectives
system.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(12), P. 18895 - 18930
Published: Dec. 6, 2021
Light
is
an
attractive
tool
that
has
a
profound
impact
on
modern
medicine.
Particularly,
light-based
photothermal
therapy
(PTT)
and
photodynamic
(PDT)
show
great
application
prospects
in
the
prevention
of
wound
infection
promoting
healing.
In
addition,
hydrogels
have
shown
advantages
field
dressings
due
to
their
excellent
biochemical
effects.
Therefore,
multifunctional
photoresponsive
(MPRHs)
integrate
light
are
increasingly
used
biomedicine,
especially
repair.
However,
comprehensive
review
MPRHs
for
regeneration
still
lacking.
This
first
focuses
various
types
prepared
by
diverse
photosensitizers,
agents
(PHTAs)
including
transition
metal
sulfide/oxides
nanomaterials,
nanostructure-based
PHTAs,
carbon-based
conjugated
polymer
or
complex-based
and/or
(PHDAs)
such
as
ZnO-based,
black-phosphorus-based,
TiO2-based,
small
organic
molecule-based
PHDAs.
We
also
then
discuss
how
PTT,
PDT,
photothermal/photodynamic
synergistic
can
modulate
microenvironments
bacteria
inhibit
infection.
Overall,
with
both
therapeutic
tissue
capabilities
been
discussed
existing
challenges,
well
future
research
directions
management
argued.
Frontiers in Chemistry,
Journal Year:
2020,
Volume and Issue:
8
Published: May 27, 2020
Coronavirus
disease
2019
(COVID-19)
outbreak
has
become
a
global
pandemic.
The
deleterious
effects
of
coronavirus
have
prompted
the
development
diagnostic
tools
to
manage
its
spread.
While
conventional
technologies
such
as
quantitative
real
time
polymerase
chain
reaction
(qPCR)
been
broadly
used
detect
COVID-19,
they
are
time-consuming,
labor-intensive
and
unavailable
in
remote
settings.
Point-of-care
(POC)
biosensors,
including
chip-based
paper-based
biosensors
typically
low-cost
user-friendly,
which
offer
tremendous
potential
for
rapid
medical
diagnosis.
This
mini
review
article
discusses
recent
advances
POC
COVID-19.
First,
made
polydimethylsiloxane
(PDMS),
papers
other
flexible
materials
textile,
film
carbon
nanosheets
reviewed.
advantages
each
along
with
commercially
available
COVID-19
highlighted.
Lastly,
existing
challenges
future
perspectives
developing
robust
rapidly
identify
spread
briefly
discussed.
Bioactive Materials,
Journal Year:
2020,
Volume and Issue:
6(5), P. 1491 - 1511
Published: Nov. 16, 2020
Successful
regeneration
of
large
segmental
bone
defects
remains
a
major
challenge
in
clinical
orthopedics,
thus
it
is
important
significance
to
fabricate
suitable
alternative
material
stimulate
regeneration.
Due
their
excellent
biocompatibility,
sufficient
mechanical
strength,
and
similar
structure
composition
natural
bone,
the
mineralized
collagen
scaffolds
(MCSs)
have
been
increasingly
used
as
substitutes
via
tissue
engineering
approaches.
Herein,
we
thoroughly
summarize
state
art
MCSs
tissue-engineered
for
acceleration
repair,
including
fabrication
methods,
critical
factors
osteogenesis
regulation,
current
opportunities
challenges
future.
First,
methods
MCSs,
mainly
direct
mineral
composite,
in-situ
mineralization
3D
printing
techniques,
proposed
improve
biomimetic
physical
structures
this
review.
Meanwhile,
three
aspects
(mechanics
morphology),
biological
(cells
growth
factors)
chemical
(composition
cross-linking)
cues
are
described
regulating
osteogenic
feature
MCSs.
Finally,
associated
with
also
discussed
point
out
future
directions
building
next
generation
that
should
be
endowed
satisfactorily
mimetic
appropriately
characters
Theranostics,
Journal Year:
2019,
Volume and Issue:
10(2), P. 757 - 781
Published: Dec. 6, 2019
The
marked
augment
of
drug-resistance
to
traditional
antibiotics
underlines
the
crying
need
for
novel
replaceable
antibacterials.Research
advances
have
revealed
considerable
sterilization
potential
two-dimension
graphene-based
nanomaterials.Subsequently,
two-dimensional
nanomaterials
beyond
graphene
(2D
NBG)
as
antibacterials
also
demonstrated
their
power
disinfection
due
unique
physicochemical
properties
and
good
biocompatibility.Therefore,
exploration
antibacterial
mechanisms
2D
NBG
is
vital
manipulate
future
applications.Herein,
we
summarize
recent
research
progress
NBG-based
agents,
starting
with
a
detailed
introduction
relevant
mechanisms,
including
direct
contact
destruction,
oxidative
stress,
photo-induced
antibacterial,
control
drug/metallic
ions
releasing,
multi-mode
synergistic
antibacterial.Then,
effect
on
activities
discussed.Additionally,
summary
different
kinds
given,
such
transition-metal
dichalcogenides/oxides,
metal-based
compounds,
nitride-based
nanomaterials,
black
phosphorus,
transition
metal
carbides,
nitrides.Finally,
rationally
analyze
current
challenges
new
perspectives
study
more
effective
agents.This
review
not
only
can
help
researchers
grasp
status
antibacterials,
but
may
catalyze
breakthroughs
in
this
fast-growing
field.
ACS Applied Nano Materials,
Journal Year:
2021,
Volume and Issue:
4(11), P. 11353 - 11385
Published: Nov. 16, 2021
Photothermal
therapy
(PTT)
is
recognized
as
a
promising
approach
for
cancer
theranostics
via
the
nonradiative
conversion
of
light
into
heat
energy.
PTT
treatment
able
to
reduce
adverse
side
effects
traditional
chemotherapy.
Some
nanomaterials
functionalized
with
unique
physical
and
chemical
properties
have
been
integrated
multiple
imaging
modalities
therapeutic
function
applications.
In
past
decade,
various
applications
reviewed,
but
comprehensive
survey
all
classes
photothermal
developed
in
recent
years
has
not
done.
A
discussion
mechanisms
using
different
their
application
combination
useful
providing
insights
material
development
disease
future.
this
review,
advancement
excellence
combined
therapies
field
anticancer
are
discussed.
The
momentous
property
tailored
advancing
noninvasive
also
highlighted.
Because
great
deal
decades
reviewed
years,
we
only
include
latest
results
reported
5
comparison.
