Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

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A MOF-Based Potent Ferroptosis Inducer for Enhanced Radiotherapy of Triple Negative Breast Cancer

ACS Nano, Journal Year: 2023, Volume and Issue: 17(14), P. 13195 - 13210

Published: May 31, 2023

Radiotherapy (RT) is one of the important clinical treatments for local control triple-negative breast cancer (TNBC), but radioresistance still exists. Ferroptosis has been recognized as a natural barrier progression and represents significant role RT-mediated anticancer effects, while simultaneous activation ferroptosis defensive system during RT limits synergistic effect between ferroptosis. Herein, we engineered tumor microenvironment (TME) degradable nanohybrid with dual radiosensitization manner to combine induction high-Z based on metal-organic frameworks ferroptosis-augmented TNBC. The encapsulated l-buthionine-sulfoximine (BSO) could inhibit glutathione (GSH) biosynthesis peroxidase 4 (GPX4) inactivation break down system, delivered ferrous ions act powerful executor via triggering Fenton reaction; combination them induces potent ferroptosis, which synergize surface decorated Gold (Au) NPs-mediated improve efficacy. In vivo antitumor results revealed that significantly therapeutic efficacy antimetastasis efficiency combinational mechanism RT. This work thus demonstrated combining efficient through nanotechnology was feasible promising strategy TNBC treatment.

Language: Английский

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Radiotherapy-mediated redox homeostasis-controllable nanomedicine for enhanced ferroptosis sensitivity in tumor therapy

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 159, P. 300 - 311

Published: Jan. 13, 2023

Language: Английский

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Ferroptosis Nanomedicine: Clinical Challenges and Opportunities for Modulating Tumor Metabolic and Immunological Landscape

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15328 - 15353

Published: Aug. 13, 2023

Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid peroxidation, has captured much attention in the field nanomedicine since it was coined 2012. Compared with other modes such as apoptosis and pyroptosis, ferroptosis many distinct features molecular mechanisms cellular morphology, representing promising strategy for treating cancers that are resistant to conventional therapeutic modalities. Moreover, recent insights collectively reveal is tightly connected maintenance tumor immune microenvironment (TIME), suggesting potential application therapies evoking robust antitumor immunity. From biochemical perspective, intricately multiple metabolic pathways, including iron metabolism, lipid redox etc., highlighting importance elucidate relationship between metabolism developing therapies. In this review, we provide comprehensive discussion on current understanding ferroptosis-inducing thoroughly discuss various traits tumors, which offer opportunities direct inhibition through nanointegrated approach. Extending from complex impact TIME, also discussed those important considerations development ferroptosis-based immunotherapy, challenges strategies enhance ferroptosis-enabled immunostimulatory effects while avoiding side effects. We envision study may facilitate translation nanomedicines treatment.

Language: Английский

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Nanomedomics

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 10979 - 11024

Published: April 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Language: Английский

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A wearable electrostimulation-augmented ionic-gel photothermal patch doped with MXene for skin tumor treatment

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 26, 2024

Abstract A wearable biological patch capable of producing multiple responses to light and electricity without interfering with daily activities is highly desired for skin cancer treatment, but remains a key challenge. Herein, the skin-mountable electrostimulation-augmented photothermal (eT-patch) comprising transparent ionic gel MXene (Ti 3 C 2 T x) doping developed applied treatment melanoma under photostimulation at 0.5 W/cm . The eT-patch designed has superior electrical characteristics owing gels doped which provides high conversion efficiency conductivity as medium. Simultaneously, gel-based having excellent optical transparency actualizes real-time observation response process stimulation (PES) co-therapy. Systematical cellular study on anti-tumor mechanism PES revealed that can synergically trigger cell apoptosis pyroptosis, together lead death cells. Due obvious advantages relatively safe less side effects in healthy organs, promising cost-effective therapeutic strategy tumors will open new avenue biomedical applications gels.

Language: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

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Iron-Containing Protein-Mimic Supramolecular Iron Delivery Systems for Ferroptosis Tumor Therapy

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 145(1), P. 160 - 170

Published: Dec. 21, 2022

Ferroptosis provides an innovative theoretical basis and method for tumor therapy but is limited by the low efficiency of conventional iron delivery systems. Herein, efficient supramolecular system (SIDS) demonstrated upon hydrolysis FeCl3, condensation amino acids, self-assembly iron-containing components. The as-assembled SIDS possesses a shuttle-like core/shell structure with β-FeOOH as core Fe3+/polyamino acid coordinated networks shells. content up to 42 wt %, which greatly higher than that ferritin. protein-mimic morphology facilitate accumulation cell internalization. Once exposed microenvironment overexpressed glutathione (GSH), will disassemble, accompanied depletion GSH release Fe2+, leading dual amplified ferroptosis. Primary studies indicate exhibits outstanding antitumor efficacy on bladder cancer.

Language: Английский

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Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

Regenerative Biomaterials, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 1, 2023

Abstract Ferroptosis, a completely new form of regulated cell death, is mainly caused by an imbalance between oxidative damage and reductive protection has shown great anti-cancer potential. However, existing small-molecule ferroptosis inducers have various limitations, such as poor water solubility, drug resistance low targeting ability, hindering their clinical applications. Nanotechnology provides opportunities for ferroptosis-driven tumor therapy. Especially, stimuli-responsive nanomaterials stand out among others been widely researched because unique spatiotemporal control advantages. Therefore, it’s necessary to summarize the application those in ferroptosis. Here, we describe physiological feature illustrate current challenges induce cancer Then, that are classified elaborated according external internal stimuli. Finally, future perspectives field proposed. We hope this review facilitates paving way design intelligent nano-ferroptosis inducers.

Language: Английский

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DNAzyme‐Mediated Cascade Nanoreactor for Cuproptosis‐Promoted Pancreatic Cancer Synergistic Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(28)

Published: Aug. 7, 2023

Abstract Cuproptosis, a kind of newly recognized cell death modality, shows enormous prospect in cancer treatment. The inducer cuproptosis has more advantages tumor therapy, especially that can trigger and chemodynamic therapy (CDT) simultaneously. However, is restricted to the deficiency intracellular copper ions nonspecific delivery copper‐based ionophores. Therefore, high level delivery, responsive release, utilizing synergistic‐function become key on cuproptosis‐based oncotherapy. In this work, cascade nanosystem constructed for enhanced CDT. weak acidic environment cells, DNA, zinc ions, Cu + release from nanosystem. Since having superior performance mediating both Fenton‐like reaction cuproptosis, released induces CDT efficiently, accompanied by 2+ generation. Then be converted into partially glutathione (GSH) supply loop ensure synergistic action. Meanwhile, consumption GSH also contributes return. Finally, DNA Zn form DNAzyme shear catalase‐related RNA, resulting accumulation hydrogen peroxide further enhancing combination therapy. These results provide promising nanotherapeutic platform may inspire design potential treatment based cuproptosis.

Language: Английский

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