Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 27, 2024
Abstract
Reactive
oxygen
species
(ROS)‐mediated
sonodynamic
therapy
(SDT)
holds
increasing
potential
in
treating
deep‐seated
tumor
owing
to
the
high
tissue‐penetration
depth.
However,
inevitable
accumulation
of
sonosensitizers
normal
tissues
not
only
make
it
difficult
realize
situ
SDT,
but
also
induces
effects
tissues.
Herein,
this
work
reports
passivation
and
selective
activation
strategies
for
near‐infrared
(NIR)
imaging
performances
an
intelligent
antitumor
theranostic
platform
termed
Cu‐IR783
nanoparticles
(NPs).
Owing
ruptured
coordination
bond
between
IR783
with
Cu
ions
by
responding
microenvironment
(TME),
occurred
achieve
visualized
in‐situ
SDT.
The
tumor‐specific
released
realized
cascade
amplification
ROS
generation
through
+
‐mediated
Fenton‐like
reaction,
triggered
cuproptosis
‐induced
DLAT
oligomerization
mitochondrial
dysfunction.
More
importantly,
immunosuppressive
TME
can
be
reversed
greatly
enhanced
levels
high‐efficiency
cuproptosis,
ultimately
inducing
immunogenic
cell
death
that
promotes
robust
systemic
immune
responses
eradication
primary
tumors
suppression
distant
tumors.
This
provides
a
distinct
paradigm
integration
CDT,
controlled
manner
therapy.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(27), P. 17852 - 17868
Published: June 28, 2024
The
discovery
of
cuproptosis,
a
copper-dependent
mechanism
programmed
cell
death,
has
provided
way
for
cancer
treatment.
However,
cuproptosis
inherent
limitations,
including
potential
cellular
harm,
the
lack
targeting,
and
insufficient
efficacy
as
standalone
Therefore,
exogenously
controlled
combination
treatments
have
emerged
key
strategies
cuproptosis-based
oncotherapy.
In
this
study,
Cu2–xSe@cMOF
nanoplatform
was
constructed
combined
sonodynamic/cuproptosis/gas
therapy.
This
platform
enabled
precise
cotreatment,
with
external
control
allowing
selective
induction
in
cells.
approach
effectively
prevented
metastasis
recurrence.
Furthermore,
antiprogrammed
death
protein
ligand-1
antibody
(aPD-L1),
maximized
advantages
immune
checkpoint
Additionally,
under
ultrasound
irradiation,
H2Se
gas
generated
from
induced
cytotoxicity
Further,
it
reactive
oxygen
species,
which
hindered
survival
proliferation.
study
reports
an
externally
system
that
combines
carbonized
metal–organic
framework
aPD-L1
to
enhance
precision
reinforced
therapy
could
be
valuable
effective
therapeutic
agent
reduce
mortality
morbidity
future.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
This
review
explores
the
synthesis,
drug
loading,
and
surface
modifications
of
metal–organic
frameworks
(MOFs),
highlighting
their
role
in
improving
cancer
immunotherapy
paving
way
for
safer
more
effective
treatments.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(15)
Published: Feb. 11, 2024
Abstract
Overproduction
of
reactive
oxygen
species
(ROS),
metal
ion
accumulation,
and
tricarboxylic
acid
cycle
collapse
are
crucial
factors
in
mitochondria‐mediated
cell
death.
However,
the
highly
adaptive
nature
damage‐repair
capabilities
malignant
tumors
strongly
limit
efficacy
treatments
based
on
a
single
treatment
mode.
To
address
this
challenge,
self‐reinforced
bimetallic
Mito‐Jammer
is
developed
by
incorporating
doxorubicin
(DOX)
calcium
peroxide
(CaO
2
)
into
hyaluronic
(HA)
‐modified
metal‐organic
frameworks
(MOF).
After
cellular,
dissociates
CaO
Cu
2+
tumor
microenvironment.
The
exposed
further
yields
hydrogen
(H
O
Ca
weakly
acidic
environment
to
strengthen
‐based
Fenton‐like
reaction.
Furthermore,
combination
chemodynamic
therapy
overload
exacerbates
ROS
storms
mitochondrial
damage,
resulting
downregulation
intracellular
adenosine
triphosphate
(ATP)
levels
blocking
Cu‐ATPase
sensitize
cuproptosis.
This
multilevel
interaction
strategy
also
activates
robust
immunogenic
death
suppresses
metastasis
simultaneously.
study
presents
multivariate
model
for
revolutionizing
mitochondria
relying
continuous
retention
ions
boost
cuproptosis/immunotherapy
cancer.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(18)
Published: March 26, 2024
Cuproptosis
is
dependent
on
mitochondrial
respiration
modulation
by
targeting
lipoylated
tricarboxylic
acid
cycle
(TCA)
proteins,
showing
great
potential
in
cancer
treatment.
However,
the
specific
release
of
copper
ions
at
highly
needed
and
still
a
major
challenge
to
trigger
cellular
cuproptosis.
Herein,
metal-organic
framework-based
nanoplatform
(ZCProP)
designed
for
mitochondrial-targeted
ATP/pH-responsive
Cu
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 22, 2025
Cuproptosis
differs
from
other
forms
of
cell
death,
such
as
apoptosis,
necroptosis,
and
ferroptosis,
in
its
unique
molecular
mechanisms
signaling
pathways.
In
this
review,
we
delve
into
the
cellular
metabolic
pathways
copper,
highlighting
role
copper
biomolecule
synthesis,
mitochondrial
respiration,
antioxidant
defense.
Furthermore,
elucidate
relationship
between
cuproptosis-related
genes
(CRGs)
cancer
prognosis,
analyzing
their
expression
patterns
across
various
tumor
types
impact
on
patient
outcomes.
Our
review
also
uncovers
potential
therapeutic
applications
chelators,
ionophores,
copper-based
nanomaterials
oncology.
addition,
discuss
emerging
cuproptosis
remodeling
microenvironment,
enhancing
immune
infiltration,
converting
"cold
tumors"
"hot
that
respond
better
to
immunotherapy.
short,
underscores
pivotal
importance
biology
highlights
translational
a
novel
target.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Abstract
Cuproptosis,
a
newly
identified
copper
(Cu)-dependent
form
of
cell
death,
stands
out
due
to
its
distinct
mechanism
that
sets
it
apart
from
other
known
death
pathways.
The
molecular
underpinnings
cuproptosis
involve
the
binding
Cu
lipoylated
enzymes
in
tricarboxylic
acid
cycle.
This
interaction
triggers
enzyme
aggregation
and
proteotoxic
stress,
culminating
death.
specific
has
yet
be
fully
elucidated.
recognized
sparked
numerous
investigations
into
role
tumorigenesis
cancer
therapy.
In
this
review,
we
summarized
current
knowledge
on
metabolism
link
cancer.
Furthermore,
delineated
mechanisms
roles
cuproptosis-related
genes
Finally,
offered
comprehensive
discussion
most
recent
advancements
ionophores
nanoparticle
delivery
systems
utilize
as
cutting-edge
strategy
for
treatment.
