Steering Piezocatalytic Therapy for Optimized Tumoricidal Effect DOI
Huijuan Zheng, Huimin Lin, Hao Tian

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: May 16, 2024

Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.

Language: Английский

Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications DOI
Si Chen,

Piao Zhu,

Lijie Mao

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: Jan. 12, 2023

Abstract Emerging piezocatalysts have demonstrated their remarkable application potential in diverse medical fields. In addition to ultrahigh catalytic activities, inherent and unique charge‐carrier‐releasing properties can be used initiate various redox reactions, displaying bright prospects for future applications. Triggered by mechanical energy, piezocatalytic materials release electrons/holes, catalyze reactions of substrates, or intervene biological processes promote the production effector molecules purposes, such as decontamination, sterilization, therapy. Such a piezocatalysis is termed medicine (PCM) herein. To pioneer novel technologies, especially therapeutic modalities, this review provides an overview state‐of‐the‐art research progress medicine. First, principle preparation methodologies piezoelectric are introduced. Then, comprehensive summary applications tumor treatment, antisepsis, organic degradation, tissue repair regeneration, biosensing provided. Finally, main challenges perspectives discussed proposed, expecting fuel development emerging scientific discipline.

Language: Английский

Citations

204
Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing DOI
Limin Shang, Yixin Yu, Yujie Jiang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15962 - 15977

Published: Aug. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Language: Английский

Citations

116
Piezo-photocatalysts in the field of energy and environment: Designs, applications, and prospects DOI
Liquan Jing, Yuanguo Xu, Meng Xie

et al.

Nano Energy, Journal Year: 2023, Volume and Issue: 112, P. 108508 - 108508

Published: May 6, 2023

Language: Английский

Citations

84
Achieving Clearance of Drug‐Resistant Bacterial Infection and Rapid Cutaneous Wound Regeneration Using an ROS‐Balancing‐Engineered Heterojunction DOI

Chong Geng,

Shuai He, Sheng Yu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(16)

Published: Feb. 1, 2024

Abstract Intractable infected microenvironments caused by drug‐resistant bacteria stalls the normal course of wound healing. Sono‐piezodynamic therapy (SPT) is harnessed to combat pathogenic bacteria, but superabundant reactive oxygen species (ROS) generated during SPT inevitably provoke severe inflammatory response, hindering tissue regeneration. Consequently, an intelligent nanocatalytic membrane composed poly(lactic‐co‐glycolic acid) (PLGA) and black phosphorus /V 2 C MXene bio‐heterojunctions (2D ‐bioHJs) devised. Under ultrasonication, 2D ‐bioHJs effectively eliminate disrupting metabolism electron transport chain (ETC). When ultrasonication ceases, they enable elimination SPT‐generated ROS. The act as a “lever” that achieves balance between ROS generation annihilation, delivering both antibacterial anti‐inflammatory properties engineered membrane. More importantly, in vivo assays corroborate membranes transform stalled chronic environment into regenerative one eradicating bacterial population, dampening NF‐κB pathway promoting angiogenesis. As envisaged, this work demonstrates novel tactic arm with programmed effects remedy refractory wounds from drug‐fast bacteria.

Language: Английский

Citations

61
Progress in the synthesis and applications of N-rich carbon nitride (C3N5)-based catalysts in environmental and energy catalysis DOI
Chiyu Liu, Junlei Zhang,

Wanglei Wang

et al.

Surfaces and Interfaces, Journal Year: 2023, Volume and Issue: 42, P. 103491 - 103491

Published: Oct. 9, 2023

Language: Английский

Citations

51
Defect Engineering in Nanocatalysts: From Design and Synthesis to Applications DOI
Pir Muhammad, Amir Zada, Jamshaid Rashid

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: Feb. 13, 2024

Abstract Defect engineering is an emerging technology for tailoring nanomaterials' characteristics and catalytic performance in various applications. Recently, defect‐engineered nanoparticles have emerged as highly researched materials applications because of their exceptional redox reaction capabilities physicochemical optical properties. The properties nanomaterials can be readily adjusted by controlling the nature concentration defects within nanoparticles, avoiding need intricate design strategies. This review investigates defect nanocatalysts, including design, fabrication, Initially, categories strategies nanomaterial impacts on nanocatalysts' electronic surface properties, activity, selectivity, stability are summarized. Then, processes uses, gas sensing, hydrogen (H 2 ) evolutions, water splitting, reductions carbon dioxide (CO nitrogen to value‐aided products, pollutant degradation, biomedical (oncotherapy, antibacterial wound healing, biomolecular sensing) discussed. Finally, limitations prospective paths allowing logical optimization nanocatalytic long‐term efficient also examined. comprehensive gives unique insights into current state nanocatalysts inspires future research exploiting shortcomings improve customize performance.

Language: Английский

Citations

49
Cu-GA-coordination polymer nanozymes with triple enzymatic activity for wound disinfection and accelerated wound healing DOI Open Access

Haotian Tian,

Jianqin Yan,

Wei Zhang

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 167, P. 449 - 462

Published: June 2, 2023

Language: Английский

Citations

47
A hyaluronic acid hydrogel as a mild photothermal antibacterial, antioxidant, and nitric oxide release platform for diabetic wound healing DOI
Changyuan He, Siwei Bi,

Rongya Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 543 - 555

Published: May 11, 2024

Language: Английский

Citations

30
Interconversion of sp-hybridized chemical bonds induces piezoelectric enhanced photocatalysis DOI

Wenbo Feng,

Yujie Jiang,

Fuguo Ge

et al.

Applied Catalysis B Environment and Energy, Journal Year: 2024, Volume and Issue: 349, P. 123868 - 123868

Published: April 24, 2024

Language: Английский

Citations

22
Sea Cucumber-Inspired Microneedle Nerve Guidance Conduit for Synergistically Inhibiting Muscle Atrophy and Promoting Nerve Regeneration DOI

Cewen Hu,

Bin Liu,

Xinyue Huang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14427 - 14440

Published: May 22, 2024

Muscle atrophy resulting from peripheral nerve injury (PNI) poses a threat to patient's mobility and sensitivity. However, an effective method inhibit muscle following PNI remains elusive. Drawing inspiration the sea cucumber, we have integrated microneedles (MNs) microchannel technology into guidance conduits (NGCs) develop bionic microneedle NGCs (MNGCs) that emulate structure piezoelectric function of cucumbers. Morphologically, MNGCs feature outer surface with outward-pointing needle tips capable applying electrical stimulation denervated muscles. Simultaneously, interior contains microchannels designed guide migration Schwann cells (SCs). Physiologically, incorporation conductive reduced graphene oxide zinc nanoparticles polycaprolactone scaffold enhances conductivity properties, facilitating SCs' migration, myelin regeneration, axon growth, restoration neuromuscular function. These combined effects ultimately lead inhibition Consequently, concept synergistic effect inhibiting promoting regeneration has capacity transform traditional approach repair find broad applications in repair.

Language: Английский

Citations

22