Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Language: Английский

---

Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: June 2, 2024

Abstract Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic extracellular matrix, promoting cell adhesion. Further enhancing proliferation within these matrix‐metalloproteinase‐triggered amino acid motifs. Integration cell‐friendly modules like peptides proteins expands hydrogel functionality. These exceptional properties position for diverse applications, including biomedicine, biosensors, remediation, food industry. Despite progress, there is ongoing research to optimize biomedical further. Engineering novel favorable characteristics crucial regulating tissue architecture facilitating ecological remediation. This review explores synthesis, physicochemical properties, biological implications various types their extensive biomedicine It elaborates on potential bridging gap between advancements sector solutions issues.

Language: Английский

---

Bioinspired Supramolecular Hydrogel from Design to Applications

Small Methods, Journal Year: 2023, Volume and Issue: 8(4)

Published: Aug. 20, 2023

Nature offers a wealth of opportunities to solve scientific and technological issues based on its unique structures function. The dynamic non-covalent interaction is considered be the main base living functions creatures including humans, animals, plants. Supramolecular hydrogels formed by bonding interactions has become platform for constructing promising materials medicine, energy, electronic, biological substitute. In this review, self-assemble principle supramolecular summarized. Next, stimulation external environment that triggers assembly or disassembly are recapitulated, temperature, mechanics, light, pH, ions, etc. applications bioinspired in terms bionic objects plants also described. Although so many efforts done revealing synergized mechanism function hydrogel, complexity variability between stimulus system still require impeccable theories. As an outlook, hydrogel just beginning exhibit great potential human life, offering significant drug delivery screening, implantable devices substitutions, tissue engineering, micro-fluidic devices, biosensors.

Language: Английский

---

Macrophage‐Derived Extracellular Vesicles‐Coated Palladium Nanoformulations Modulate Inflammatory and Immune Homeostasis for Targeting Therapy of Ulcerative Colitis

Advanced Science, Journal Year: 2023, Volume and Issue: 10(33)

Published: Oct. 9, 2023

Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease mainly involving the colon and rectum, which features recurrent mucosal inflammation. The excessive production of reactive oxygen species (ROS) trigger for pathological changes such as cell apoptosis disordered immune microenvironments, are crucial progression UC can be promising therapeutic target. Nowadays, development targeted strategies still in its infancy. Thus, developing effective therapies based on ROS scavenging elucidating their molecular pathways urgently needed. Herein, biomimetic nanoformulation (Pd@M) with cubic palladium (Pd) core macrophage‐derived extracellular vesicles (MEVs) shell synthesized treatment UC. These Pd@M nanoformulations exhibit multienzyme‐like activities scavenging, excellent targeting ability well good biocompatibility. It verified that regulate polarization state macrophages by inhibiting glycolysis, decrease neutrophil infiltration recruitment. In this way, colonic microenvironment remodeled, prevented, ultimately improving barrier function alleviating mouse model. This finding provides alternative option patients.

Language: Английский

---

Artificial mucus layer formed in response to ROS for the oral treatment of inflammatory bowel disease

Science Advances, Journal Year: 2024, Volume and Issue: 10(30)

Published: July 26, 2024

The artificial mucus layer, such as hydrogels, used to repair the damaged intestinal barrier, is a promising treatment for inflammatory bowel disease (IBD). However, currently reported hydrogel-based barriers are administered via rectal injection, causing unnecessary discomfort patients. Herein, we report an oral hydrogel precursor solution based on thiol-modified hyaluronic acid (HASH). Owing reactive oxygen species (ROS)–responsive gelling behavior, our formed coating over inflamed regions of intestines, blocking microbial invasion and reducing abnormally activated immune responses. Notably, HASH also modulated gut microbiota, including increasing diversity enhancing abundance short-chain fatty acid–associated bacteria, which play key role in homeostasis. We believe that ROS-responsive layer strategy IBD.

Language: Английский

---

Metabolic Nanoregulator Remodels Gut Microenvironment for Treatment of Inflammatory Bowel Disease

ACS Nano, Journal Year: 2024, Volume and Issue: 18(9), P. 7123 - 7135

Published: Feb. 23, 2024

Inflammatory bowel disease (IBD) is strongly related to the occurrence of accumulation toxic reactive oxygen species (ROS), inflammation mucosa, and an imbalance intestinal microbes. However, current treatments largely focus on a single factor, yielding unsatisfactory clinical outcomes. Herein, we report biocompatible IBD-targeted metabolic nanoregulator (TMNR) that synergistically regulates cellular bacterial metabolism. The TMNR comprises melanin-gallium complex (MNR) encapsulated within thermosensitive colitis-targeting hydrogel, all composed natural FDA-approved components. confers superior broad-spectrum antioxidant properties, effectively scavenging (ROS) blocking inflammatory signaling pathways. presence Ga3+ in selectively disrupts iron metabolism pathogenic microorganisms due its structural resemblance atom. Additionally, incorporating injectable hydrogel enables targeted delivery regions, prolonging their retention time providing physical barrier function for optimizing IBD treatment efficacy. Collectively, modulates redox balance inflamed colonic epithelial tissue microorganisms, thereby eliminating restoring homeostasis against IBD. Hence, this work presents comprehensive approach precise spatiotemporal regulation microenvironmental treatment.

Language: Английский

---

Orally administered metal–organic framework nanocubes for sequence-targeted quercetin delivery in colitis alleviation

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160373 - 160373

Published: Feb. 1, 2025

Language: Английский

---

Advancements in hydrogel-based drug delivery systems for the treatment of inflammatory bowel disease: a review

Biomaterials Science, Journal Year: 2023, Volume and Issue: 12(4), P. 837 - 862

Published: Dec. 22, 2023

Inflammatory bowel disease (IBD) is a chronic disorder that affects millions of individuals worldwide. However, current drug therapies for IBD are plagued by significant side effects, low efficacy, and poor patient compliance. Consequently, there an urgent need novel therapeutic approaches to alleviate IBD. Hydrogels, three-dimensional networks hydrophilic polymers with the ability swell retain water, have emerged as promising materials delivery in treatment due their biocompatibility, tunability, responsiveness various stimuli. In this review, we summarize recent advancements hydrogel-based systems We first identify three pathophysiological alterations be addressed IBD: damage intestinal mucosal barrier, dysbiosis flora, activation inflammatory signaling pathways leading disequilibrium within intestines. Subsequently, discuss depth processes required prepare hydrogel systems, from selection materials, types drugs loaded, methods loading release mechanisms key points preparation systems. Additionally, highlight progress impact system through regulation physical barrier immune responses, promotion repair, improvement gut microbiota. conclusion, analyze challenges clinical applications treatment, propose potential solutions our perspective.

Language: Английский

---

Self-crosslinking hyaluronic acid hydrogel as an enteroprotective agent for the treatment of inflammatory bowel disease

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132909 - 132909

Published: June 6, 2024

Language: Английский

---

ZnO-Cu/Mn nanozyme for rescuing the intestinal homeostasis in Salmonella-induced colitis

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 20, 2025

Salmonella is one of the most common foodborne pathogens, which can cause severe enteritis and intestinal microbiota imbalance. However, there are limited strategies currently available for preventing or treating Salmonella-induced colitis. Herein, we developed Cu/Mn-co-doped ZnO tandem nanozyme (ZnO-CM) with pH-responsive multienzyme-mimicking activities via doping engineering treatment Benefiting from co-doping Cu Mn, ZnO-CM nanospheres exhibit remarkable peroxidase-like activity in acidic condition superoxide dismutase- catalase-like neutral environment. Animal experiments show that efficiently inhibit bacterial growth, alleviate inflammation, restore barrier, resulting good antibacterial anti-inflammatory effects on Mechanistically, functions through inhibiting continuous accumulation ROS, increasing levels tight junction proteins occludin claudin-1, decreasing expression pro-inflammatory cytokines IL-1β IL-6 intestine. This work not only presents an effective paradigm colitis therapy, but also provides new sights into prevention other enteritis.

Language: Английский

---