A dual-responsive polydopamine-modified hydroxybutyl chitosan hydrogel for sequential regulation of bone regeneration

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 297, P. 120027 - 120027

Published: Aug. 27, 2022

Language: Английский

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Diffusion-Limited Processes in Hydrogels with Chosen Applications from Drug Delivery to Electronic Components

Molecules, Journal Year: 2023, Volume and Issue: 28(15), P. 5931 - 5931

Published: Aug. 7, 2023

Diffusion is one of the key nature processes which plays an important role in respiration, digestion, and nutrient transport cells. In this regard, present article aims to review various diffusion approaches used fabricate different functional materials based on hydrogels, unique examples that control diffusion. They have found applications fields such as drug encapsulation delivery, delivery agriculture, developing for regenerative medicine, creating stimuli-responsive soft robotics microrobotics. addition, mechanisms release kinetics tools material design are discussed.

Language: Английский

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A Mechanically Reinforced Super Bone Glue Makes a Leap in Hard Tissue Strong Adhesion and Augmented Bone Regeneration

Advanced Science, Journal Year: 2023, Volume and Issue: 10(11)

Published: Jan. 25, 2023

Abstract Existing bone tissue engineering strategies aim to achieve minimize surgical trauma, stabilize the injured area, and establish a dynamic osteogenic microenvironment. The cutting‐edge glue developed in this study satisfies these criteria. Inspired by excellent adhesive properties of mussels, herein, super (L‐DPZ) that integrates poly(vinyl alcohol), L‐dopa amino acid, zeolitic imidazolate framework‐8 characterized catechol–metal coordination is used successfully adhere hard with maximum strength 10 MPa, which much higher than those commercial previously reported glues. stable adhesion also enables it strongly luxated or broken teeth, Bio‐Oss (a typical graft material), splice fragments from comminuted fractures rabbit femur. Then, testified L‐DPZ hydrogels exhibit satisfactory biocompatibility, degradability, ability vitro. Moreover, anchor sustained osteogenesis result healing calvarial defect models rabbits, as observed increased thickness ingrowth new tissue. These results are expected demonstrate solutions clinical dilemmas such fracture fixation, reconstruction, teeth dislocation replantation.

Language: Английский

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Ten years of injectable platelet‐rich fibrin

Periodontology 2000, Journal Year: 2023, Volume and Issue: 94(1), P. 92 - 113

Published: Nov. 30, 2023

Abstract The use of platelet‐rich fibrin (PRF) has seen widespread advantages over plasma (PRP) in many fields medicine. However, until 2014, PRF remained clinically available only its solid clotted form. Modifications to centrifugation protocols and tube technology have led the development a liquid injectable version (i‐PRF). This narrative review takes look back at technological developments made throughout past decade further elaborates on their future clinical applications. Topics covered include improvements isolation techniques protocols, ways concentrate i‐PRF, impact relevance cooling i‐PRF. Next, various uses i‐PRF are discussed, including regenerative periodontology, implantology, endodontics, temporomandibular joint injections, orthodontic tooth movement. Furthermore, indications medicine also covered, sports injuries osteoarthritis joints, treatment diabetic ulcers/wound care, facial esthetics hair regrowth. Finally, applications mainly as drug delivery vehicle for small biomolecules, such growth factors, antibiotics, exosomes, other medications that may benefit from controlled gradual release biomolecules time.

Language: Английский

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3D Printing‐Based Hydrogel Dressings for Wound Healing

Advanced Science, Journal Year: 2024, Volume and Issue: 11(47)

Published: Nov. 18, 2024

Abstract Skin wounds have become an important issue that affects human health and burdens global medical care. Hydrogel materials similar to the natural extracellular matrix (ECM) are one of best candidates for ideal wound dressings most feasible choices printing inks. Distinct from hydrogels made by traditional technologies, which lack bionic mechanical properties, 3D can promptly accurately create with complex bioactive structures potential promote tissue regeneration healing. Herein, a comprehensive review multi‐functional printing‐based hydrogel healing is presented. The first summarizes techniques dressings, including photo‐curing, extrusion, inkjet, laser‐assisted printing. Then, properties design approaches series bioinks composed natural, synthetic, composite polymers described. Thereafter, application in variety environments discussed depth, hemostasis, anti‐inflammation, antibacterial, skin appendage regeneration, intelligent monitoring, machine learning‐assisted therapy. Finally, challenges prospects

Language: Английский

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Injectable Nanocomposite Hydrogels with Strong Antibacterial, Osteoinductive, and ROS-Scavenging Capabilities for Periodontitis Treatment

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(12), P. 14421 - 14433

Published: March 18, 2024

Injectable antibacterial and osteoinductive hydrogels have received considerable attention for promoting bone regeneration owing to their versatile functionalities. However, a current hydrogel with antibacterial, osteoinductive, antioxidant properties by facile method periodontitis treatment is still missing. To overcome this issue, we designed an injectable system (GPM) composed of gelatin, Ti3C2Tx MXene nanosheets, poly-l-lysine using simple enzymatic cross-linking technique. Physicochemical characterization demonstrated that the GPM matrix exhibited excellent stability, moderate tissue adhesion ability, good mechanical behavior. The significantly inhibited growth Porphyromonas gingivalis, scavenged reactive oxygen species, attenuated inflammatory responses, enhanced regeneration. Intriguingly, arrangement junctional epithelium, alveolar volume, height in GPM-treated periodontal disease group recovered healthy group. Therefore, our functions may serve as scaffold periodontitis.

Language: Английский

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Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: April 16, 2024

Platelet-rich fibrin, a classical autologous-derived bioactive material, consists of fibrin scaffold and its internal loading growth factors, platelets, leukocytes, with the gradual degradation slow release physiological doses factors. PRF promotes vascular regeneration, proliferation migration osteoblast-related cells such as mesenchymal cells, osteoblasts, osteoclasts while having certain immunomodulatory anti-bacterial effects. has excellent osteogenic potential been widely used in field bone tissue engineering dentistry. However, there are still some limitations PRF, improvement biological properties is one most important issues to be solved. Therefore, it often combined scaffolds enhance mechanical delay degradation. In this paper, we present systematic review development platelet-rich derivatives, structure mechanisms, applications, optimization broaden their clinical applications provide guidance for translation.

Language: Английский

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APCs in sinus floor augmentation

Periodontology 2000, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 16, 2024

Abstract After tooth loss in the posterior area of maxilla, sinus floor elevation is often required to compensate vertical bone due pneumatization. This narrative review reports on potential benefits autologous platelet concentrates (APCs) during this procedure. As for transcrestal approach, APCs have been used as “sole” substitute/graft. However, because low number clinical trials available with PRGF, and even none PRP, no definitive conclusions can be made regarding their efficacy. The studies use L‐PRF were outnumbered indicating good feasibility gain, a high implant survival rate degree complications. PRP PRGF not studied “single/sole” substitute one‐stage lateral window probably weak physical characteristics membranes. alone appears predictable grafting material maxillary reduced RBH should considered risk factor. Compared “standard” shows slightly less gain (consider enough membrane application bony new roof over apices), enhanced early resorption (first 6 months after application), but similar stable afterward. For two‐stage “alone” cannot recommended, withstand pneumatization forces. combined substitutes seem accelerate formation, without any additional long‐term gain. membranes treatment perforations an effective option, further are needed confirm this. Even though abovementioned statements based large numbers studies, RCTs comparing different types procedures needed.

Language: Английский

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Development of an Injectable Biphasic Hyaluronic Acid‐Based Hydrogel With Stress Relaxation Properties for Cartilage Regeneration

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(18)

Published: April 3, 2024

Biomimetic stress-relaxing hydrogels with reversible crosslinks attract significant attention for stem cell tissue regeneration compared elastic hydrogels. However, hyaluronic acid (HA)-based fabricated using conventional technologies lack stability, biocompatibility, and mechanical tunability. Here, it is aimed to address these challenges by incorporating calcium or phosphate components into the HA backbone, which allows crosslinking of alginate form interpenetrating networks, offering stability tunability mimicking cartilage. Diverse (τ1/2; SR50, 60-2000 s) are successfully prepared at ≈3 kPa stiffness self-healing shear-thinning abilities, favoring hydrogel injection. In vitro experiments RNA sequencing analysis demonstrate that tune chondrogenesis in a biphasic manner (hyaline calcified) depending on stress-relaxation properties components. vivo studies confirm potential chondrogenesis. These results indicate proposed HA-based promising material cartilage regeneration.

Language: Английский

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Ligand‐Selective Targeting of Macrophage Hydrogel Elicits Bone Immune‐Stem Cell Endogenous Self‐Healing Program to Promote Bone Regeneration

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(11)

Published: Jan. 16, 2024

Targeting macrophages can facilitate the site-specific repair of critical bone defects. Herein, a composite hydrogel, gelatin-Bletilla striata polysaccharide-mesoporous bioactive glass hydrogel (GBMgel), is constructed via self-assembly mesoporous on polysaccharide structures, through Schiff base reaction. GBMgel efficiently capture and drive recruitment seed stem cells vascular budding required for regeneration in early stages injury, observed sustained release inorganic silicon ions further enhances matrix deposition, mineralization, maturation. Moreover, use macrophage-depleted rat calvarial defect models confirms that GBMgel, with ligand-selective macrophage targeting, increases area proportion mature bone. Mechanistic studies reveal upregulates TLR4/NF-κB MAPK pathways JAK/STAT3 pathway later stages; thus initiating polarization at different time points. In conclusion, this study based endogenous self-healing properties macrophages, which cell homing, provides research theoretical basis upon tissue be reshaped regenerated using body's immune power, providing new strategy treatment

Language: Английский

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