Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Language: Английский

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Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(11), P. 6007 - 6023

Published: March 7, 2023

Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD) characterized by release pro-inflammatory cytokines. Our knowledge pyroptosis has expanded beyond cellular level and now includes extracellular responses. In recent years, attracted considerable attention due its potential induce host immunity. For instance, at 2022 International Medicinal Chemistry Natural Active Ligand Metal-Based Drugs (MCNALMD) conference, numerous researchers demonstrated an interest in photon-controlled activation ("PhotoPyro"), emerging pyroptosis-engineered approach for activating systemic immunity via photoirradiation. Given this enthusiasm, we share Perspective our views on area expound how why "PhotoPyro" could trigger antitumor (i.e., turning so-called "cold" tumors "hot"). doing so, have tried highlight cutting-edge breakthroughs PhotoPyro while suggesting areas future contributions. By providing insights into current state art serving as a resource individuals interested working area, it is hoped that will set stage evolve broadly applicable cancer treatment strategy.

Language: Английский

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An acid-responsive MOF nanomedicine for augmented anti-tumor immunotherapy via a metal ion interference-mediated pyroptotic pathway

Biomaterials, Journal Year: 2023, Volume and Issue: 302, P. 122333 - 122333

Published: Sept. 16, 2023

Language: Английский

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Stimuli-responsive drug delivery systems triggered by intracellular or subcellular microenvironments

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114773 - 114773

Published: March 9, 2023

Language: Английский

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Recent advances in organelle-targeted organic photosensitizers for efficient photodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215710 - 215710

Published: Feb. 20, 2024

Language: Английский

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Oxygen‐carrying semiconducting polymer nanoprodrugs induce sono‐pyroptosis for deep‐tissue tumor treatment

Exploration, Journal Year: 2024, Volume and Issue: 4(4)

Published: Feb. 19, 2024

Abstract Sonodynamic therapy (SDT) has been explored for cancer therapy, especially deep tumors due to its low tissue penetration restriction. The therapeutic efficacy of SDT is limited the complicated tumor microenvironment. This study reports construction oxygen‐carrying semiconducting polymer nanoprodrugs (OSPN pro ) treatment via combining amplified with pyroptosis. An oxygen carrier perfluorohexane, sonodynamic as sonosensitizer, and reactive species (ROS)‐responsive prodrug are co‐loaded into a nanoparticle system, leading formation these nanoprodrugs. Such OSPN show an effective accumulation in tissues after systemic administration, which they deliver relieve hypoxia microenvironment thus mediate producing ROS under ultrasound (US) irradiation, even when covered 2‐cm chicken breast tissue. In addition, ROS‐responsive prodrugs activated by generated trigger pyroptosis cells. sono‐pyroptosis induces strong antitumor immunity obviously higher level infiltrations effector immune cells tumors. Therefore, ‐based combinational can greatly inhibit growth tissue‐covered suppress metastasis. offers nanoplatform strategy.

Language: Английский

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The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 7, 2024

Abstract Immune checkpoint blockers (ICBs) have been applied for cancer therapy and achieved great success in the field of immunotherapy. Nevertheless, broad application ICBs is limited by low response rate. To address this issue, increasing studies found that induction immunogenic cell death (ICD) tumor cells becoming an emerging therapeutic strategy treatment, not only straightly killing but also enhancing dying immunogenicity activating antitumor immunity. ICD a generic term representing different modes containing ferroptosis, pyroptosis, autophagy apoptosis. Traditional chemotherapeutic agents usually inhibit growth based on apoptotic ICD, most are resistant to Thus, non-apoptotic considered be more efficient approach therapy. In addition, due ineffective localization inducers, various types nanomaterials being developed achieve targeted delivery improved immunotherapeutic efficiency. review, we briefly outline molecular mechanisms pyroptosis autophagy, as well their reciprocal interactions with immunity, then summarize current progress ICD-induced nanoparticles strategies illustrate applications Graphical

Language: Английский

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Circulating immunotherapy strategy based on pyroptosis and STING pathway: Mn-loaded paclitaxel prodrug nanoplatform against tumor progression and metastasis

Biomaterials, Journal Year: 2024, Volume and Issue: 306, P. 122472 - 122472

Published: Jan. 23, 2024

Language: Английский

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Design of Calixarene‐Based ICD Inducer for Efficient Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(16)

Published: Jan. 20, 2023

Abstract Immunogenic cell death (ICD), which in situ generates cancer vaccines and elicits protective cognate anticancer immunity, has brought brightness to immunotherapy. However, poor immunogenicity low response rate of current ICD‐inducing strategies restrict the development clinical application ICD‐based Herein, a novel calixarene, quaternary ammonium‐modified azocalix[4]arene (CA‐3) that drive bona fide ICD with high efficiency, is presented. In addition, unique macrocyclic structure offers CA‐3 great potential bind drugs via host–guest interactions. With these two functions one molecule, effectively cooperates various chemotherapeutics improve their performance by activating ICD‐associated anti‐tumor immunity. These characteristics make CA‐3, general platform for improving prognosis many chemotherapies commonly used practice. Furthermore, structure‐activity relationship established this study also provides insights design synthesis more efficient calixarene‐based inducers.

Language: Английский

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Biomimetic Prussian blue nanocomplexes for chemo-photothermal treatment of triple-negative breast cancer by enhancing ICD

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122369 - 122369

Published: Oct. 24, 2023

Language: Английский

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