Biological effects of metal-based nanomaterials for tumor metalloimmunotherapy

Nano Today, Journal Year: 2023, Volume and Issue: 53, P. 102033 - 102033

Published: Oct. 31, 2023

Language: Английский

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Photo‐Activated Oxidative Stress Amplifier: A Strategy for Targeting Glutathione Metabolism and Enhancing ROS‐Mediated Therapy in Triple‐Negative Breast Cancer Treatment

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 3, 2024

Abstract Amplifying oxidative stress within tumor cells can effectively inhibit the growth and metastasis of triple‐negative breast cancer (TNBC). Therefore, development innovative nanomedicines that disrupt redox balance represents a promising yet challenging therapeutic strategy for TNBC. In this study, an amplifier, denoted as PBCH, comprising PdAg mesoporous nanozyme CaP mineralized layer, loaded with GSH inhibitor L‐buthionine sulfoximine (BSO), further surface‐modified hyaluronic acid target CD44, is introduced. acidic microenvironment, Ca 2+ initially released, thereby leading to mitochondrial dysfunction eventually triggering apoptosis. Additionally, BSO suppresses synthesis intracellular reduced amplifies level in cells. Furthermore, be activated by near‐infrared light induce photothermal photodynamic effects, causing burst ROS simultaneously promoting cell apoptosis via provoking immunogenic death. The high‐performance effects based on synergistic effect aforementioned multiple damage ablation, are validated TNBC animal models, declaring its potential safe effective anti‐tumor agent. proposed approach offers new perspectives precise efficient treatment

Language: Английский

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Polymeric nanocarrier via metabolism regulation mediates immunogenic cell death with spatiotemporal orchestration for cancer immunotherapy

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 4, 2024

The limited efficacy of cancer immunotherapy occurs due to the lack spatiotemporal orchestration adaptive immune response stimulation and immunosuppressive tumor microenvironment modulation. Herein, we report a nanoplatform fabricated using pH-sensitive triblock copolymer synthesized by reversible addition-fragmentation chain transfer polymerization enabling in situ vaccination tumor-associated macrophages (TAMs) polarization. nanocarrier itself can induce melanoma immunogenic cell death (ICD) via tertiary amines thioethers concentrating on mitochondria regulate metabolism triggering endoplasmic reticulum stress upregulating gasdermin D for pyroptosis as well some features ferroptosis apoptosis. After addition ligand cyclic arginine-glycine-aspartic acid (cRGD) mannose, mixed with adjuvant resiquimod encapsulation target B16F10 cells TAMs M1 phenotype In vivo studies indicate that targeting elicits ICD, dendritic maturation, TAM polarization, cytotoxic T lymphocyte infiltration inhibits volume growth. combination checkpoint blockade, survival time mice is markedly prolonged. This study provides strategy utilizing immunoactive materials innate responses augment therapy.

Language: Английский

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CaO₂ nanomedicines: a review of their emerging roles in cancer therapy

Nanotechnology, Journal Year: 2023, Volume and Issue: 34(48), P. 482002 - 482002

Published: Aug. 24, 2023

Metal peroxide-based nanomedicines have emerged as promising theranostic agents for cancer due to their multifunctional properties, including the generation of bioactive small molecules such metal ions, H2O2, O2, and OH-. Among these peroxides, calcium peroxide (CaO2) attracted significant attention facile synthesis good biocompatibility. CaO2nanoparticles been explored treatment through three main mechanisms: (1) release which helps alleviate tumor hypoxia enhances oxygen-dependent therapies chemotherapy, photodynamic therapy, immunotherapy; (2) a precursor ·OH generation, enables chemodynamic therapy; (3) Ca2+ions, induce overload promote cell apoptosis (called ion-interference therapy). This review provides comprehensive summary recent examples CaO2nanoparticle-based therapeutic strategies, well discusses challenges future directions in development CaO2nanomedicines treatment.

Language: Английский

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Construction of Natural Polysaccharide-Based pH-Responsive Gold Nanorods for Combined Photothermal Therapy and Immunotherapy

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 10466 - 10478

Published: April 18, 2024

Photothermal therapy and immunotherapy are emerging strategies for treating tumors. The combination of these two therapies can effectively leverage their advantages, thereby enhancing the therapeutic efficacy. Based on this premise, natural polysaccharide was prepared from edible Rosa roxburghii fruit applied to coat gold nanorods (GNRs). antitumor nanorods, designated as RRP-MPBA-GNRs, were developed combine photothermal immunotherapy. This system employed 4-mercaptophenylboronic acid (MPBA) connecting unit. hydroxy groups RRP formed dynamic borate ester bonds with MPBA, conjugated exhibited pH-responsive properties. RRP-MPBA immobilized surface GNRs through sulfur–gold bonds, stability preserving effects GNRs. In vivo experiments have demonstrated that RRP-MPBA-GNRs reduced number cancer cells at transplant site inhibited metastasis. Further investigation revealed increase reactive oxygen species (ROS) levels in induce apoptosis. released an immune response by promoting maturation dendritic up-regulating expression marker molecules. results suggested integrate tumor treatment.

Language: Английский

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Targeting Hydrogel for Intelligent Recognition and Spatiotemporal Control in Cell‐Based Therapeutics

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 14, 2024

Abstract Smart drug platforms based on spatiotemporally controlled release and integration of tumor imaging are expected to overcome the inefficiency uncertainty traditional theranostic modes. In this study, a composite consisting thermosensitive hydrogel (polyvinyl alcohol‐carboxylic acid (PCF)) multifunctional nanoparticle (Fe 3 O 4 @Au/Mn(Zn)‐4‐carboxyphenyl porphyrin/polydopamine (FAM x P)) is developed combine immunogenic cell death (ICD)/immune checkpoint blockade (ICB) therapy under guidance magnetic resonance (MRI) fluorescence (FI). It can not only further recognize target cells through folate receptor cells, but also produce thermal dissolution after exposure near‐infrared light slowly FAM P in situ, thereby prolonging treatment time avoiding recurrence. As entered it released pH‐dependent manner. Chemodynamic, photothermal photodynamic cause significant ICD cancer cells. ICB thus be enhanced by injecting anti‐programmed ligand 1, improving effectiveness treatment. The PCF‐FAM may represent an updated design approach with simple compositions for cooperative MRI/FI‐guided targeted therapeutic pathways tumors.

Language: Английский

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Tumor microenvironment activation amplify oxidative stress promoting tumor energy remodeling for mild photothermal therapy and cuproptosis

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103260 - 103260

Published: June 28, 2024

Tumor metabolic reprogramming requires high levels of adenosine triphosphate (ATP) to maintain treatment resistance, which poses major challenges chemotherapy and photothermal therapy. Especially, ATP promote copper ion efflux for limiting the curative effect cuproptosis. Here, an H

Language: Английский

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Erythrocyte membrane-camouflaged DNA-functionalized upconversion nanoparticles for tumor-targeted chemotherapy and immunotherapy

Nanoscale, Journal Year: 2023, Volume and Issue: 15(21), P. 9457 - 9476

Published: Jan. 1, 2023

We report the new biomimetic nanoparticles, which is synergistic combination of immunogenic cell death inducer and immunoadjuvant, proving to be unique strategy successfully induce an immune response boost anticancer response.

Language: Английский

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Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy

Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 181 - 198

Published: July 5, 2023

Summary Immunogenic cell death (ICD) is a special pattern of tumor death, enabling to elicit tumor‐specific immune response via the release damage‐associated molecular patterns and tumor‐associated antigens in microenvironment. ICD‐induced immunotherapy holds promise for completely eliminating tumors long‐term protective antitumor response. Increasing ICD inducers have been discovered boosting immunity evoking ICD. Nonetheless, utilization remains insufficient owing serious toxic reactions, low localization efficiency within microenvironmental niche, etc. For overcoming such limitations, stimuli‐responsive multifunctional nanoparticles or nanocomposites with developed improving immunotherapeutic lowering toxicity, which represent prospective scheme fostering immunotherapy. This review outlines advances near‐infrared (NIR)‐, pH‐, redox‐, pH‐ NIR‐ microenvironment‐responsive nanodelivery systems induction. Furthermore, we discuss their clinical translational potential. The progress settings depends upon development biologically safer drugs tailored patient needs. Moreover, an in‐depth comprehending biomarkers, immunosuppressive microenvironment, may accelerate advance smarter further amplify

Language: Английский

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Manganese Dioxide-based In Situ Vaccine Boosts Antitumor Immunity via Simultaneous Activation of Immunogenic Cell Death and the STING Pathway

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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