Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 25, 2024
Abstract
Polyphenol
hydrogels
have
found
widespread
application
in
wound
healing,
bone
repair,
drug
delivery,
and
biosensors
due
to
their
robust
wet
adhesion,
high
ductility,
excellent
self‐healing
ability.
However,
these
often
exhibit
low
intrinsic
cohesion,
which
limits
overall
adhesive
strength.
Enhancing
cohesion
is
critical
for
improving
both
the
adhesion
mechanical
properties
of
hydrogels,
thereby
expanding
utility
biomedical
fields.
This
review
begins
by
exploring
strategies
enhance
polyphenol
hydrogel
adhesives,
detailing
modifications
that
act
individually
or
synergistically.
The
importance
temporally
regulating
emphasized
accommodate
various
applications
environmental
conditions.
Finally,
this
paper
discusses
remaining
challenges
regulation
outlines
prospects
future
research.
It
hoped
comprehensive
will
provide
new
insights
into
development
advanced
polyphenolic
adhesives
contribute
design
“smart
adhesives”
increasingly
complex
needs
applications.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
21, P. 100729 - 100729
Published: July 11, 2023
Infectious
disease
is
one
of
the
top
10
causes
death
worldwide,
especially
in
low-income
countries.
The
extensive
use
antibiotics
has
led
to
an
increase
antibiotic
resistance,
which
poses
a
critical
threat
human
health
globally.
Natural
products
such
as
polyphenolic
compounds
and
their
derivatives
have
been
shown
positive
therapeutic
effects
antibacterial
therapy.
However,
inherent
physicochemical
properties
limit
pharmaceutical
effects,
short
half-lives,
chemical
instability,
low
bioavailability,
poor
water
solubility.
Nanoformulations
promising
advantages
improving
activity
by
controlling
release
drugs
enhancing
bioavailability
polyphenols.
In
this
review,
we
listed
classification
mechanisms
compounds.
More
importantly,
nanoformulations
for
delivery
polyphenols
agent
were
summarized,
including
different
types
nanoparticles
(NPs)
polymer-based
NPs,
metal-based
lipid-based
nanoscaffolds
nanogels,
nanofibers,
nanoemulsions.
At
same
time,
also
presented
potential
biological
applications
nano-system
enhance
ability
polyphenols,
aiming
provide
new
perspective
antibiotic-free
treatment
infectious
diseases.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(10)
Published: Jan. 2, 2024
The
presence
of
bacteria
in
diabetic
wounds
not
only
leads
to
the
formation
biofilms
but
also
triggers
oxidative
stress
and
inflammatory
responses,
which
hinder
wound-healing
process.
Therefore,
it
is
imperative
formulate
a
comprehensive
strategy
that
can
proficiently
eliminate
enhance
wound
microenvironment.
Herein,
this
work
develops
multifunctional
metal-phenolic
nanozymes
(TA-Fe/Cu
nanocapsules),
wherein
one-pot
coordination
tannic
acid
(TA)and
Fe
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
36, P. 185 - 202
Published: March 5, 2024
Wound
healing
in
cases
of
excessive
inflammation
poses
a
significant
challenge
due
to
compromised
neovascularization.
Here,
we
propose
multi-functional
composite
hydrogel
engineered
overcome
such
conditions
through
recruitment
and
activation
macrophages
with
adapted
degradation
the
hydrogel.
The
(G-TSrP)
is
created
by
combining
gelatin
methacryloyl
(GelMA)
nanoparticles
(TSrP)
composed
tannic
acid
(TA)
Sr2+.
These
are
prepared
using
one-step
mineralization
process
assisted
metal-phenolic
network
formation.
G-TSrP
exhibits
ability
eliminate
reactive
oxygen
species
direct
polarization
toward
M2
phenotype.
It
has
been
observed
that
liberation
TA
Sr2+
from
actively
facilitate
up-regulation
expression
extracellular
matrix
remodeling
genes
macrophages,
thereby,
coordinate
vivo
G-TSrP.
Most
significantly,
accelerates
angiogenesis
despite
TA's
inhibitory
properties,
which
counteracted
released
Moreover,
enhances
wound
closure
under
promotes
normal
tissue
formation
strong
vessel
growth.
Genetic
analysis
confirms
macrophage-mediated
Collectively,
these
findings
pave
way
for
development
biomaterials
promote
creating
regenerative
environment.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 5, 2025
Abstract
Bacterial
infections
are
a
significant
obstacle
to
the
healing
of
acute
and
chronic
wounds,
such
as
diabetic
ulcers
burn
injuries.
Traditional
antibiotics
primary
treatment
for
bacterial
infections,
but
they
present
issues
antibiotic
resistance,
limited
efficacy,
potential
side
effects.
This
challenge
leads
exploration
nanozymes
alternative
therapeutic
agents.
Nanozymes
nanomaterials
with
enzyme‐like
activities.
Owing
their
low
production
costs,
high
stability,
scalability,
multifunctionality,
have
emerged
prominent
focus
in
antimicrobial
research.
Among
various
types
nanozymes,
metal‐based
offer
several
benefits,
including
broad‐spectrum
activity
robust
catalytic
properties.
Specifically,
copper‐based
(CuNZs)
shown
considerable
promoting
wound
healing.
They
exhibit
strong
effects,
reduce
inflammation,
enhance
tissue
regeneration,
making
them
highly
advantageous
use
care.
review
describes
dual
functions
CuNZs
combating
infection
facilitating
repair.
Recent
advancements
design
synthesis
CuNZs,
evaluating
promotion,
biosafety
both
vitro
vivo
on
basis
core
components,
critically
important.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
32, P. 260 - 276
Published: Oct. 13, 2023
Bacterial
infection
and
scar
formation
remain
primary
challenges
in
wound
healing.
To
address
these
issues,
we
developed
a
decellularized
pomelo
peel
(DPP)
functionalized
with
an
adhesive
PVA-TSPBA
hydrogel
antibacterial
gallic
acid/copper
MOFs.
The
hybrid
dressing
demonstrates
favorable
biocompatibility.
It
does
not
impede
the
proliferation
of
fibroblasts
or
immune
cells
can
stimulate
fibroblast
migration,
endothelial
angiogenesis,
M2
macrophage
polarization.
Additionally,
scavenge
reactive
oxygen
species
(ROS)
provide
antioxidant
effects.
Furthermore,
DPP
+
MOF@Gel
effectively
inhibits
viability
S.
aureus
E.
coli
vitro
vivo.
histological
observations
revealed
enhanced
granulation
tissue
formation,
re-epithelialization,
angiogenesis
group
compared
to
other
groups.
local
response
also
shifted
from
pro-inflammatory
pro-regenerative
status
treatment.
skin
incision
stitching
experiment
further
exhibits
could
reduce
during
Taken
together,
holds
great
promise
for
treating
bacteria-infected
wounds
inhibiting
