Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 5, 2024
Abstract Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers ubiquitously released from cells under normal pathological conditions. Human serum is a rich source of these EVs, though their isolation proteins non-EV lipid particles poses challenges. These transport various cellular components such as proteins, mRNAs, miRNAs, DNA, lipids across distances, influencing numerous physiological events, including those within tumor microenvironment (TME). Their pivotal roles in communication make EVs promising candidates for therapeutic agents, drug delivery systems, disease biomarkers. Especially cancer diagnostics, EV detection can pave way early identification offers potential diagnostic Moreover, subtypes emerging targeted tools, highlighting clinical significance. The need non-invasive biomarkers to monitor biological processes purposes remains unfulfilled. Tapping unique composition could unlock advanced avenues future. In this review, we discuss detail conditions, cancers (encompassing head neck, lung, gastric, breast, hepatocellular carcinoma), neurodegenerative disorders, diabetes, viral infections, autoimmune renal diseases, emphasizing advancements molecular diagnostics delivery.
Language: Английский
Citations
291
Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 19(1), P. 13 - 20
Published: Dec. 18, 2023
Language: Английский
Citations
46
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)
Published: Jan. 17, 2024
Abstract Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing and treating cancer chronic diseases promote growth nanomedicine. However, there are very few analytical descriptive studies regarding trajectory nanomedicine, key research powers, present landscape, focal investigative points, future outlooks. Herein, articles reviews published Science Citation Index Expanded Web Core Collection from first January 2000 to 18th July 2023 analyzed. a bibliometric visualization publication trends, countries/regions, institutions, journals, categories, themes, references, keywords is produced elaborated. Nanomedicine‐related academic output increasing since COVID‐19 pandemic, solidifying uneven global distribution performance. While China leads terms quantity has numerous highly productive USA advantages impact, commercialization, industrial value. Nanomedicine integrates with other disciplines, establishing interdisciplinary platforms, which drug delivery nanoparticles remain points. Current focuses on integrating nanomedicine cell ferroptosis induction immunotherapy. The keyword “burst testing” identifies promising directions, including immunogenic death, chemodynamic therapy, tumor microenvironment, immunotherapy, extracellular vesicles. prospects, major challenges, barriers addressing these directions discussed.
Language: Английский
Citations
39
Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)
Published: June 14, 2024
Abstract In recent decades, research on Extracellular Vesicles (EVs) has gained prominence in the life sciences due to their critical roles both health and disease states, offering promising applications diagnosis, drug delivery, therapy. However, inherent heterogeneity complex origins pose significant challenges preparation, analysis, subsequent clinical application. This review is structured provide an overview of biogenesis, composition, various sources EVs, thereby laying groundwork for a detailed discussion contemporary techniques preparation analysis. Particular focus given state‐of‐the‐art technologies that employ microfluidic non‐microfluidic platforms EV processing. Furthermore, this discourse extends into innovative approaches incorporate artificial intelligence cutting‐edge electrochemical sensors, with particular emphasis single proposes current outlines prospective avenues future research. The objective motivate researchers innovate expand methods analysis fully unlocking biomedical potential.
Language: Английский
Citations
35
Journal of Extracellular Vesicles, Journal Year: 2024, Volume and Issue: 13(7)
Published: July 1, 2024
Abstract Nowadays, it has become clear that extracellular vesicles (EVs) are not a cellular waste disposal vesicle but an essential part of intercellular communication system. Besides the use EVs in biomarker studies and diagnostics, potential EV‐therapeutics been seen by many. They provide unique properties for disease therapy, including strong immune‐modulatory actions, possibility engineering, low immunogenicity, capability crossing biological barriers. Proof‐of‐concept various pathologies achieved preclinical studies. However, clinical trials with have only emerging slowly. Here, we aim to comprehensive overview current state‐of‐the‐art concerning using human therapy. By approaching knowledge systematic manner, were able include 21 reports meta‐analysis safety evaluation efficacy outcomes. Overall, shown EV‐based therapy is safe incidence serious adverse events (SAE; 0.7% (95%‐CI: 0.1–5.2%), (AE; 4.4% 0.7–22.2%). Subgroup analysis showed no significant difference SAE when comparing autologous versus allogeneic administration, as well engineered non‐engineered EV products. A significantly higher number AE was administration. relevance remains questionable. Evaluation outcomes immunostimulatory, immunosuppressive or regenerative EV‐therapies indicated improvement majority treated patients. Despite these promising results, data need be approached caution due high heterogeneity manufacturing methods, study design, reporting (S)AE. conclude presents opportunity More efforts needed standardization harmonization isolation characterization (S)AE allow inter‐study comparison.
Language: Английский
Citations
27
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 8489 - 8506
Published: April 15, 2024
Cancer is the most challenging health complication worldwide. Scientific society has tried to decode its complications and developing a smart solution for mankind. Extracellular vesicles (EVs) are an emerging frontier in cancer research. EVs provide fresh insight into understanding of released from all active cells. classified some major classes, such as apoptotic bodies, microvesicles, exosomes. Exosomes among exciting tools current research they work cellular messengers (which reflects cell's healthy or pathological conditional status). In tumor microenvironment, regulate several complicated events uncontrolled cell growth, immune suppression, angiogenesis, extracellular matrix remodeling, metastasis, organ-specific drug therapeutic resistance, stem development. also source promising biomarkers involved both diagnosis prognosis performs role. Exosomes-based nanomedicine which application nanosize theranostics sensor orientation, supports overcoming management limitations, early therapeutics specific, effective, affordable. this review, we have highlighted integration exosomes nanotechnology cutting-edge approach precision oncology.
Language: Английский
Citations
14
Regenerative Therapy, Journal Year: 2024, Volume and Issue: 26, P. 260 - 274
Published: June 1, 2024
Chronic wounds represent a significant global burden, afflicting millions with debilitating complications. Despite standard care, impaired healing persists due to factors like persistent inflammation and tissue regeneration. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) offer an innovative regenerative medicine approach, delivering cell-derived therapeutic cargo in engineered nanoscale delivery systems. This review examines pioneering bioengineering strategies engineer MSC-EVs into precision nanotherapeutics for chronic wounds. Emerging technologies CRISPR gene editing, microfluidic manufacturing, biomimetic systems are highlighted their potential enhance MSC-EV targeting, optimize enrichment, ensure consistent clinical-grade production. However, key hurdles remain, including batch variability, rigorous safety assessment tumorigenicity, immunogenicity, biodistribution profiling. Crucially, collaborative frameworks harmonizing regulatory science patient advocacy hold the expediting clinical translation. By overcoming these challenges, could catalyze new era of off-the-shelf therapies, restoring hope afflicted by non-healing
Language: Английский
Citations
10
Theranostics, Journal Year: 2024, Volume and Issue: 14(5), P. 2265 - 2289
Published: Jan. 1, 2024
Extracellular vesicles (EVs) are produced by all cells in the body. These biological nanoparticles facilitate cellular communication through transport of diverse cargoes, including small molecules, proteins, and nucleic acids. mRNA cargoes have gained particular interest given their role translation functional proteins. As a biomarker platform, EVs can be found nearly biofluids-blood, mucus, urine, cerebrospinal fluid, saliva-providing real-time insight into parent cell tissue function. mRNAs carried protected from degradation, resulting improved detection compared to free mRNA, recent work demonstrates promising results using these as biomarkers for cancer, neurological diseases, infectious gynecologic obstetric outcomes. Furthermore, innate cargo carrying, targeting, barrier crossing abilities EVs, structures been proposed therapeutic carriers mRNA. Recent advances demonstrate methods loading range disease indications. Here, we review studies diagnostics therapeutics. We discuss challenges associated with diagnostic applications highlight opportunities future development.
Language: Английский
Citations
8
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
As we progress into the 21st century, cancer stands as one of most dreaded diseases. With approximately in every four individuals facing a lifetime risk developing cancer, remains serious health challenges worldwide. Its multifaceted nature makes it an arduous and tricky problem to diagnose treat. Over years, researchers have explored plenty approaches avenues improve management. One notable strategy includes study extracellular vesicles (EVs) potential biomarkers therapeutics. Among these EVs, exosomes emerged particularly promising candidates due their unique characteristic properties functions. They are small membrane-bound secreted by cells carrying cargo biomolecules such proteins, nucleic acids, lipids. These play crucial roles intercellular communication, facilitating transfer biological information between cell-to-cell communication. Exosomes transport cargoes DNA, RNA, lipids involved cellular reprogramming promoting cancer. In this review, explore molecular composition exosomes, significance chemistry development, its theranostic application well research complications solutions.
Language: Английский
Citations
1