A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 329, P. 121795 - 121795

Published: Jan. 9, 2024

Language: Английский

---

Regulated cell death‐amplified sonodynamic anti‐tumor immune nanotherapeutics

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

Abstract Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages high penetration, non‐radiation, and excellent oxidative stress effect, but always suffered from self‐protection mechanism apoptosis resistance characteristics evolutionarily mutated cells. Regulated cell death (RCD) received increasing attention in precision treatments because significant role synergistically sensitizing reversing immunosuppressive microenvironment during SDT nanomedicine‐triggered immunogenic death. Herein, paradigmatic research RCD‐augmented tumor immunotherapeutics are typically introduced, such autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, coordinated anti‐tumor mechanisms discussed detail. Multiple analysis focusing on currently unsolved problems future development prospects RCD‐based nano‐oncology medicine also prospected further strengthen expand scope therapeutic applications.

Language: Английский

---

Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 470 - 485

Published: Feb. 2, 2024

Language: Английский

---

Emerging role of immunogenic cell death in cancer immunotherapy: Advancing next-generation CAR-T cell immunotherapy by combination

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217079 - 217079

Published: June 25, 2024

Language: Английский

---

Polymer-based nanodrugs enhance sonodynamic therapy through epigenetic reprogramming of the immunosuppressive tumor microenvironment

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 125 - 137

Published: Feb. 5, 2025

Language: Английский

---

A ferroptosis-reinforced nanocatalyst enhances chemodynamic therapy through dual H2O2 production and oxidative stress amplification

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 892 - 904

Published: Feb. 24, 2024

Language: Английский

---

An ultrasound-activated nanoplatform remodels tumor microenvironment through diverse cell death induction for improved immunotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 501 - 515

Published: May 9, 2024

Language: Английский

---

Robust and Sustained STING Pathway Activation via Hydrogel-Based In Situ Vaccination for Cancer Immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 29439 - 29456

Published: Oct. 15, 2024

The stimulator of interferon genes (STING) pathway is crucial for tumor immunity, leading to the exploration STING agonists as potential immunotherapy adjuvants. However, their clinical application faces obstacles including poor pharmacokinetics, transient activation, and an immunosuppressive microenvironment (TME). Addressing these limitations, our study aims develop injectable silk fibroin hydrogel-based in situ vaccine. It incorporates a nanoscale agonist, immunogenic cell death (ICD) inducer, immunomodulator ensure controlled sustained release. cGAMP nanoparticles (cGAMPnps) with core–shell structure optimal delivery dendritic cells (DCs), thereby activating fostering DC maturation. ICD-associated damage-associated molecular patterns amplify prolong activation via enhanced type I IFN other inflammatory pathways, along delayed degradation STING. Furthermore, STING-driven vascular normalization by cGAMPnps ICD, conjunction immunomodulators like antiprogrammed protein 1 antibody (anti-PD-1 Ab) or OX40 ligand (OX40L), effectively remodels TME. This gel vaccine, when used independently surgery neoadjuvant/adjuvant immunotherapy, enhances CD8+ T-cell suppressing progression recurrence across various immunologically cold models. revolutionizes cancer offering substantial promise improving outcomes broad spectrum malignancies.

Language: Английский

---

Nanomedicine for combination of chemodynamic therapy and immunotherapy of cancers

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(18), P. 4607 - 4629

Published: Jan. 1, 2024

The combination of chemodynamic therapy (CDT) with immunotherapy can result in enhanced therapeutic effects cancers. recent progresses and challenges concerning nanomedicine for CDT are summarized discussed.

Language: Английский

---

Mechanisms and therapeutic targets of ferroptosis: Implications for nanomedicine design

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 14(7), P. 100960 - 100960

Published: March 8, 2024

Ferroptosis is a nonapoptotic form of cell death and differs considerably from the well-known forms in terms morphology, genetics, biochemistry. The three primary pathways for ferroptosis are system Xc-/glutathione peroxidase 4 (GPX4), lipid metabolism, ferric metabolism. Since discovery ferroptosis, mounting evidence has revealed its critical regulatory role several diseases, especially as novel potential target cancer therapy, thereby attracting increasing attention fields tumor biology anti-tumor therapy. Accordingly, broad prospects exist identifying therapeutic target. In this review, we aimed to systematically summarize activation defense mechanisms highlight targets, discuss design nanomedicines regulation. addition, opted present advantages disadvantages current research provide an optimistic vision future directions related fields. Overall, aim new ideas further inspire strategies disease diagnosis treatment.

Language: Английский

---