Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
60(2), P. 706 - 710
Published: Sept. 26, 2020
Concerning
that
the
residues
of
photosensitizers
(PS)
may
cause
serious
side
effects
under
light,
it
is
great
significant
to
timely
switch-off
PS
after
photodynamic
therapy
(PDT).
Herein,
we
proposed
a
supramolecular
strategy
regulate
activity
PS,
fabricating
with
improved
reactive
oxygen
species
(ROS)
generation
efficiency
and
accelerated
self-degradation
ability.
During
PDT
treatment,
exhibited
good
therapeutic
as
well
reduced
dark
toxicity.
Moreover,
could
be
degraded
by
ROS
generated
itself
lose
its
activities
once
treatment
finished.
In
this
way,
can
without
sacrificing
efficiency.
This
work
provides
novel
for
smarter
beacon
further
improve
safety
treatment.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(21), P. 13454 - 13619
Published: Sept. 28, 2021
This
review
presents
a
robust
strategy
to
design
photosensitizers
(PSs)
for
various
species.
Photodynamic
therapy
(PDT)
is
photochemical-based
treatment
approach
that
involves
the
use
of
light
combined
with
light-activated
chemical,
referred
as
PS.
Attractively,
PDT
one
alternatives
conventional
cancer
due
its
noninvasive
nature,
high
cure
rates,
and
low
side
effects.
PSs
play
an
important
factor
in
photoinduced
reactive
oxygen
species
(ROS)
generation.
Although
concept
photosensitizer-based
photodynamic
has
been
widely
adopted
clinical
trials
bioimaging,
until
now,
our
surprise,
there
no
relevant
article
on
rational
designs
organic
PDT.
Furthermore,
most
published
articles
focused
nanomaterials
nanotechnology
based
traditional
PSs.
Therefore,
this
aimed
at
reporting
recent
strategies
develop
innovative
enhanced
therapy,
each
example
described
detail
instead
providing
only
general
overview,
typically
done
previous
reviews
PDT,
provide
intuitive,
vivid,
specific
insights
readers.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(11), P. 6891 - 6952
Published: May 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2021,
Volume and Issue:
9
Published: Feb. 18, 2021
Skin
wounds
not
only
cause
physical
pain
for
patients
but
also
are
an
economic
burden
society.
It
is
necessary
to
seek
out
efficient
approach
promote
skin
repair.
Hydrogels
considered
effective
wound
dressings.
They
possess
many
unique
properties
like
biocompatibility,
biodegradability,
high
water
uptake
and
retention
etc.,
so
that
they
promising
candidate
materials
healing.
Chitosan
a
polymeric
biomaterial
obtained
by
the
deacetylation
of
chitin.
With
easy
acquisition,
antibacterial
hemostatic
activity,
ability
regeneration,
hydrogel-like
functional
dressings
(represented
chitosan
its
derivatives)
have
received
extensive
attentions
their
effectiveness
mechanisms
in
promoting
In
this
review,
we
extensively
discussed
with
which
chitosan-based
hemostasis,
anti-inflammation,
proliferation
granulation
We
provided
latest
information
about
applications
such
treatment.
addition,
summarized
methods
enhance
advantages
maintain
intrinsic
nature
via
incorporating
other
chemical
components,
active
biomolecules
substances
into
hydrogels.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2022,
Volume and Issue:
17(3), P. 353 - 384
Published: Jan. 24, 2022
Bacterial
infection
and
the
ever-increasing
bacterial
resistance
have
imposed
severe
threat
to
human
health.
And
contamination
could
significantly
menace
wound
healing
process.
Considering
sophisticated
process,
novel
strategies
for
skin
tissue
engineering
are
focused
on
integration
of
bioactive
ingredients,
antibacterial
agents
included,
into
biomaterials
with
different
morphologies
improve
cell
behaviors
promote
healing.
However,
a
comprehensive
review
anti-bacterial
dressing
enhance
has
not
been
reported.
In
this
review,
various
as
dressings
will
be
discussed.
Different
kinds
agents,
including
antibiotics,
nanoparticles
(metal
metallic
oxides,
light-induced
agents),
cationic
organic
others,
their
recent
advances
summarized.
Biomaterial
selection
fabrication
structures
forms,
films,
hydrogel,
electrospun
nanofibers,
sponge,
foam
three-dimension
(3D)
printed
scaffold
regeneration,
elaborated
Current
challenges
future
perspectives
presented
in
multidisciplinary
field.
We
envision
that
provide
general
insight
elegant
design
further
refinement
dressing.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
31(16)
Published: March 3, 2019
Photothermal
nanomaterials
that
integrate
multimodal
imaging
and
therapeutic
functions
provide
promising
opportunities
for
noninvasive
targeted
diagnosis
treatment
in
precision
medicine.
However,
the
clinical
translation
of
existing
photothermal
nanoagents
is
severely
hindered
by
their
unclear
physiological
metabolism,
which
makes
them
a
strong
concern
biosafety.
Here,
utilization
biliverdin
(BV),
an
endogenic
near-infrared
(NIR)-absorbing
pigment
with
well-studied
metabolic
pathways,
to
develop
aim
providing
efficient
metabolizable
candidates
tumor
therapy,
demonstrated.
It
shown
BV
intense
NIR
absorption,
long-term
photostability
colloidal
stability,
high
conversion
efficiency
can
be
readily
constructed
supramolecular
multicomponent
self-assembly
BV,
metal-binding
short
peptides,
metal
ions
through
reciprocity
synergy
coordination
multiple
noncovalent
interactions.
In
vivo
data
reveal
selectively
accumulate
tumors,
locally
elevate
temperature
under
mild
irradiation,
consequently
induce
ablation
biocompatibility.
Furthermore,
serve
as
contrast
visualization
both
photoacoustic
magnetic
resonance
imaging.
has
no
biosafety
concerns,
thereby
offers
great
potential
medicine
integrating
theranostic
functions.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(9), P. 3324 - 3340
Published: Jan. 1, 2022
This
tutorial
review
highlights
the
concept
and
significance
of
antibacterial
phototherapy.
Recent
developments,
advantages,
challenges
organic
photosensitizers
in
this
area
are
also
discussed.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(2), P. 2468 - 2480
Published: Feb. 10, 2021
Chronic
bacterial-infected
wound
healing/skin
regeneration
remains
a
challenge
due
to
drug
resistance
and
the
poor
quality
of
repair.
The
ideal
strategy
is
combating
bacterial
infection,
while
facilitating
satisfactory
healing.
However,
reported
hardly
achieves
these
two
goals
simultaneously
without
help
antibiotics
or
bioactive
molecules.
In
this
work,
two-dimensional
(2D)
Ti3C2Tx
MXene
with
excellent
conductivity,
biocompatibility,
antibacterial
ability
was
applied
in
developing
multifunctional
scaffolds
(HPEM)
for
methicillin-resistant
Staphylococcus
aureus
(MRSA)-infected
HPEM
were
fabricated
by
reaction
between
poly(glycerol-ethylenimine),
MXene@polydopamine
(MXene@PDA)
nanosheets,
oxidized
hyaluronic
acid
(HCHO).
presented
properties
containing
self-healing
behavior,
electrical
tissue-adhesive
feature,
activity
especially
MRSA
resistant
many
commonly
used
(antibacterial
efficiency
99.03%),
rapid
hemostatic
capability.
enhanced
proliferation
normal
skin
cells
negligible
toxicity.
Additionally,
obviously
accelerated
MRSA-infected
healing
(wound
closure
ratio
96.31%)
efficient
anti-inflammation
effects,
promoting
cell
proliferation,
angiogenic
process,
stimulating
granulation
tissue
formation,
collagen
deposition,
vascular
endothelial
differentiation,
angiogenesis.
This
study
indicates
important
role
2D
MXene@PDA
nanosheets
infected
provide
potential
regeneration.
ACS Nano,
Journal Year:
2019,
Volume and Issue:
13(12), P. 13797 - 13808
Published: Nov. 7, 2019
Antibacterial
agents
with
high
antibacterial
efficiency
and
bacteria-binding
capability
are
highly
desirable.
Herein,
we
describe
the
successful
preparation
of
Cu2WS4
nanocrystals
(CWS
NCs)
excellent
activity.
CWS
NCs
small
size
(∼20
nm)
achieve
more
than
5
log
(>99.999%)
inactivation
both
Staphylococcus
aureus
(Gram-positive)
Escherichia
coli
(Gram-negative)
at
low
concentration
(<2
μg
mL-1)
or
without
ambient
light,
which
is
much
better
most
reported
nanomaterials
(including
Ag,
TiO2,
etc.)
even
widely
used
antibiotics
(vancomycin
daptomycin).
mechanism
study
showed
that
have
enzyme-like
(oxidase
peroxidase)
properties
selective
ability,
greatly
facilitate
production
reactive
oxygen
species
to
kill
bacteria.
Animal
experiments
further
indicated
can
effectively
treat
wounds
infected
methicillin-resistant
(MRSA).
This
work
demonstrates
potential
as
effective
nanozymes
for
treatment
bacterial
infection.
