Biomimetic peptide self-assembly for functional materials

Nature Reviews Chemistry, Journal Year: 2020, Volume and Issue: 4(11), P. 615 - 634

Published: Sept. 15, 2020

Language: Английский

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NIR Light‐Driving Barrier‐Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(11)

Published: Feb. 5, 2020

Abstract Traditional photothermal therapy requires high‐intensity laser excitation for cancer treatments due to the low conversion efficiency (PCE) of agents (PTAs). PTAs with ultra‐high PCEs can decrease required excited light intensity, which allows safe and efficient in deep tissues. In this work, a PTA is synthesized high PCE 88.3% based on BODIPY scaffold, by introducing CF 3 “barrier‐free” rotor meso ‐position (tfm‐BDP). both ground state, moiety tfm‐BDP has no energy barrier rotation, allowing it efficiently dissipate absorbed (NIR) photons as heat. Importantly, barrier‐free rotation be maintained after encapsulating into polymeric nanoparticles (NPs). Thus, irradiation intensity (0.3 W cm −2 , 808 nm) lead complete tumor ablation tumor‐bearing mice intravenous injection NPs. This strategy “barrier‐free rotation” provides new platform future design PTT clinical treatment.

Language: Английский

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Beyond the Visible: Bioinspired Infrared Adaptive Materials

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(14)

Published: Feb. 24, 2021

Abstract Infrared (IR) adaptation phenomena are ubiquitous in nature and biological systems. Taking inspiration from natural creatures, researchers have devoted extensive efforts for developing advanced IR adaptive materials exploring their applications areas of smart camouflage, thermal energy management, biomedical science, many other IR‐related technological fields. Herein, an up‐to‐date review is provided on the recent advancements bioinspired promising applications. First overview artificial technologies presented. Recent endeavors then introduced toward camouflage radiative cooling. According to Stefan‐Boltzmann law, can be realized by either emissivity engineering or cloaks. cooling maximize radiation object through atmospheric transparency window, thus holds great potential use energy‐efficient green buildings personal management advances emerging near‐IR (NIR) also discussed, including NIR‐triggered technologies, NIR light‐fueled soft robotics, light‐driven supramolecular nanosystems. This concludes with a perspective challenges opportunities future development materials.

Language: Английский

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Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs

ACS Nano, Journal Year: 2020, Volume and Issue: 14(3), P. 2585 - 2627

Published: Feb. 7, 2020

Nanotheranostics is one of the biggest scientific breakthroughs in nanomedicine. Most currently available diagnosis and therapies are invasive, time-consuming, associated with severe toxic side effects. Nanotheranostics, on other hand, has potential to bridge this gap by harnessing capabilities nanotechnology nanomaterials for combined therapeutics diagnostics markedly enhanced efficacy. However, nanomaterial applications nanotheranostics still its infancy. This due fact that each disease a particular microenvironment well-defined characteristics, which promotes deeper selection criteria meet needs. In review, we have outlined how designed tailored cancer diseases such as neurodegenerative, autoimmune (particularly rheumatoid arthritis), cardiovascular diseases. The penetrability retention biological system, therapeutic strategy used, imaging mode selected some aspects discussed disease. specific properties terms feasibility, physicochemical challenges, progress clinical trials, toxicity, their future application translational medicine addressed. Our review meticulously critically examines various nanomaterials, including graphene, across several diseases, offering broader perspective emerging field.

Language: Английский

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Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Polymers, Journal Year: 2020, Volume and Issue: 12(3), P. 580 - 580

Published: March 5, 2020

Poly(N-isopropylacrylamide) (PNIPAM)-based thermosensitive hydrogels demonstrate great potential in biomedical applications. However, they have inherent drawbacks such as low mechanical strength, limited drug loading capacity and biodegradability. Formulating PNIPAM with other functional components to form composited is an effective strategy make up for these deficiencies, which can greatly benefit their practical This review seeks provide a comprehensive observation about the PNIPAM-based composite applications so guide related research. It covers general principles from materials choice hybridization strategies well performance improvement by focusing on several application areas including delivery, tissue engineering wound dressing. The most include incorporation of inorganic nanoparticles or self-assembled structures give linking polymer blocks unique properties produce copolymeric hydrogels, improve enhancing giving higher biocompatibility biodegradability, introducing multi-stimuli responsibility, enabling controlled release. These aspects will be help promoting development

Language: Английский

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Supramolecular Photothermal Effects: A Promising Mechanism for Efficient Thermal Conversion

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(10), P. 3793 - 3801

Published: Oct. 1, 2019

Abstract Supramolecular assemblies have been very successful in regulating the photothermal conversion efficiency of organic materials a simple and flexible way, compared with conventional molecular synthesis. In these assemblies, it is inherent physiochemical mechanism that determines conversion, rather than assembly strategy. This Minireview summarizes supramolecular effects, which refer to unique features chemistry for efficiency. Emphasis placed on mechanisms how self‐assembly affects performance. The effects various types light‐harvesting species are discussed detail. timely interpretation promising future design high efficiency, precision, multiple functionalities wide array applications.

Language: Английский

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A Supramolecular Radical Dimer: High‐Efficiency NIR‐II Photothermal Conversion and Therapy

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(43), P. 15526 - 15531

Published: Sept. 3, 2019

Photothermal therapy at the NIR-II biowindow (1000-1350 nm) is drawing increasing interest because of its large penetration depth and maximum permissible exposure. Now, supramolecular radical dimer, fabricated by N,N'-dimethylated dipyridinium thiazolo[5,4-d]thiazole cation (MPT.+ ) cucurbit[8]uril (CB[8]), achieves strong absorption biowindow. The dimer (2MPT.+ -CB[8]) showed highly efficient photothermal conversion improved stability, thus contributing to inhibition on HegG2 cancer cell under 1064 nm irradiation even penetrating through chicken breast tissue. This work provides a novel approach construct chromophore tailor-made assembly organic radicals. It anticipated that this study new strategy achieve holds promises in luminescence materials, optoelectronic also biosensing.

Language: Английский

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Light: A Magical Tool for Controlled Drug Delivery

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(49)

Published: Sept. 9, 2020

Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application and exquisite temporal spatial control. Great progress has been achieved in the development novel light-driven strategies with both breadth depth. Light-controlled platforms can be generally categorized into three groups: photochemical, photothermal, photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, sulfides oxides, metal-organic frameworks, carbon nanomaterials, upconversion semiconductor stimuli-responsive micelles, polymer- liposome-based nanoparticles have applied light-stimulated delivery. In view increasing interest targeted delivery, we review light-responsive systems focus on recent advances, key limitations, future directions.

Language: Английский

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Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 30(6)

Published: Nov. 8, 2019

Abstract Combination cancer immunotherapy has shown promising potential for simultaneously eliciting antitumor immunity and modulating the immunosuppressive tumor microenvironment (ITM). However, combination with multiple regimens suffers from varied chemo‐physical properties inconsistent pharmacokinetic profiles of different therapeutics. To achieve tumor‐specific codelivery immune modulators, an indocyanine green (ICG)‐templated self‐assembly strategy preparing dual drug‐loaded two‐in‐one nanomedicine is reported. ICG‐templated paclitaxel (PTX) nanoparticles (ISPN), application ISPN triple negative breast (TNBC) are demonstrated. The show satisfied colloidal stability high efficacy ICG PTX through enhanced permeability retention effect. Upon laser irradiation, component highly efficiently induces immunogenic cell death cells via activating response photodynamic therapy. Meanwhile, delivered by suppresses regulatory T lymphocytes (T regs ) to combat ITM. treatment TNBC αPD‐L1‐medaited checkpoint blockade therapy displays a synergistic effect on regression, metastasis inhibition, recurrence prevention. Overall, may represent robust nanoplatform immunotherapy.

Language: Английский

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Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy

Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 12(1), P. 92 - 106

Published: Aug. 14, 2021

Nanoparticulate drug delivery systems (Nano-DDSs) have emerged as possible solution to the obstacles of anticancer delivery. However, clinical outcomes and translation are restricted by several drawbacks, such low loading, premature leakage carrier-related toxicity. Recently, pure nano-assemblies (PDNAs), fabricated self-assembly or co-assembly molecules, attracted considerable attention. Their facile reproducible preparation technique helps remove bottleneck nanomedicines including quality control, scale-up production translation. Acting both carriers cargos, carrier-free PDNAs an ultra-high even 100% loading. In addition, combination therapies based on could possibly address most intractable problems in cancer treatment, tumor metastasis resistance. present review, latest development for treatment is overviewed. First, classified according composition assembly mechanisms discussed. Furthermore, co-delivery summarized, with special focus improvement therapeutic outcomes. Finally, future prospects challenges efficient therapy spotlighted.

Language: Английский

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