Catalytic Nanomaterials toward Atomic Levels for Biomedical Applications: From Metal Clusters to Single-Atom Catalysts

ACS Nano, Journal Year: 2021, Volume and Issue: 15(2), P. 2005 - 2037

Published: Feb. 10, 2021

Single-atom catalysts (SACs) featuring the complete atomic utilization of metal, high-efficient catalytic activity, superior selectivity, and excellent stability have been emerged as a frontier in field. Recently, increasing interests drawn to apply SACs biomedical fields for enzyme-mimic catalysis disease therapy. To fulfill demand precision personalized medicine, precisely engineering structure active site toward levels is trend nanomedicines, promoting evolution metal-based nanomaterials, particularly biocatalytic from nanoparticles clusters now SACs. This review outlines syntheses, characterizations, mechanisms metal SACs, with focus on their applications including biosensing, antibacterial therapy, cancer well an emphasis vivo biological safeties. Challenges future perspectives are ultimately prospected diverse applications.

Language: Английский

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Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(27)

Published: Oct. 30, 2019

Engineered nanomaterials have been extensively employed as therapeutics for tumor management. Meanwhile, the complex niche along with multiple barriers at cellular level collectively hinders action of nanomedicines. Here, advanced strategies that hold promise overcoming numerous biological facing nanomedicines are summarized. Starting from entry, methods promote tissue penetration nanomedicine and address hypoxia issue also highlighted. Then, emphasis is given to significance both physical barriers, such membrane-associated efflux pumps, features, resistance apoptosis. The pros cons an individual approach presented. In addition, associated technical problems discussed, importance balancing therapeutic merits additional cost sophisticated designs.

Language: Английский

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Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration

Small, Journal Year: 2020, Volume and Issue: 16(20)

Published: April 24, 2020

Antioxidant nanoparticles have recently gained tremendous attention for their enormous potential in biomedicine. However, discrepant reports of either medical benefits or toxicity, and lack reproducibility many studies, generate uncertainties delaying effective implementation. Herein, the case cerium oxide is considered, a well-known catalyst petrochemistry industry one first antioxidant proposed medicine. Like other nanoparticles, it now described as promising therapeutic alternative, threatening to health. Sources these discrepancies how this analysis helps overcome contradictions found are summarized discussed. For context analysis, what has been reported liver reviewed, where diseases related oxidative stress. Since well-dispersed passively accumulate liver, represents major testing field study new nanomedicines clinical translation. Even more, contradictory works cerium-oxide-associated toxicity protection against stress inflammation. Based on this, finally, intention propose solutions design improved that will work more precisely medicine safely society.

Language: Английский

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Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting

Journal of Medicinal Chemistry, Journal Year: 2019, Volume and Issue: 62(23), P. 10475 - 10496

Published: July 24, 2019

Nanoparticles with multifunctionality are being designed and formulated to overcome various limitations of drugs as well conventional drug delivery systems. Engineered nanoparticles specifically target cancer cells have the ability reduce collateral damage on normal tissue due pan-toxic effects drugs. Pragmatic approaches in consideration make advancement therapy new developed methods exhibited an improved targeted anticancer therapeutic better treatment outcomes. An effective requires both passive active targeting, along a consistent knowledge physiologic barriers successfully achieve delivery. The can be linked tumor targeting moieties like specific ligands, monoclonal antibodies, carbohydrates for great affinity precision. This review presents some recent research also discusses examples types engineered exploited targeting.

Language: Английский

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Toxicity of manufactured nanomaterials

Particuology, Journal Year: 2021, Volume and Issue: 69, P. 31 - 48

Published: Nov. 30, 2021

Manufactured nanomaterials with unique properties have been extensively applied in various industrial, agricultural or medical fields. However, some of the identified to be closely related nanomaterial toxicity. The "nano-paradox" has aroused concerns over use and development nanotechnology, which makes it difficult for regulatory agencies regulate nanomaterials. key fulfilling proper regulation lies adequate understanding impact on nano-bio interactions. To this end, we start present work a brief introduction interactions at different levels. Based that, how toxicity-associated manufactured (i.e., size, shape, chemical composition, surface properties, biocorona formation, agglomeration and/or aggregation state, biodegradability) their toxicokinetics, cellular uptake, trafficking responses, toxicity mechanisms is deeply explored. Moreover, advanced analytical methods studying are introduced. Furthermore, current legislative frameworks nanomaterial-containing products regions countries presented. Finally, propose several challenges facing nanotoxicology field possible solutions shed light safety evaluation

Language: Английский

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Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 176, P. 113870 - 113870

Published: July 16, 2021

Language: Английский

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Emerging carbon-supported single-atom catalysts for biomedical applications

Matter, Journal Year: 2022, Volume and Issue: 5(10), P. 3341 - 3374

Published: Oct. 1, 2022

Language: Английский

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Polysaccharides and Metal Nanoparticles for Functional Textiles: A Review

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(6), P. 1006 - 1006

Published: March 18, 2022

Nanotechnology is a powerful tool for engineering functional materials that has the potential to transform textiles into high-performance, value-added products. In recent years, there been considerable interest in development of using metal nanoparticles (MNPs). The incorporation MNPs allows obtention multifunctional properties, such as ultraviolet (UV) protection, self-cleaning, and electrical conductivity, well antimicrobial, antistatic, antiwrinkle, flame retardant without compromising inherent characteristics textile. Environmental sustainability also one main motivations innovation textile industry. Thus, synthesis ecofriendly sources, polysaccharides, high importance. functions polysaccharides these processes are reduction stabilization MNPs, adhesion onto fabrics. This review covers major research attempts obtain with different properties MNPs. reported include chitosan, alginate, starch, cyclodextrins, cellulose, silver, zinc, copper, titanium being most explored applications functionalized reported, they healthcare (wound dressing, drug release), protection (antimicrobial activity, UV retardant), environmental remediation (catalysts).

Language: Английский

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Engineered drug-loaded cellular membrane nanovesicles for efficient treatment of postsurgical cancer recurrence and metastasis

Science Advances, Journal Year: 2022, Volume and Issue: 8(49)

Published: Dec. 9, 2022

Cancer recurrence and metastasis are still common causes of postsurgery death in patients with solid tumors, suggesting that additional consolidation therapeutic strategies necessary. We have previously found oxaliplatin (OXA) treatment further up-regulation CD155, which is abundantly expressed tumors for resulting increased sensitivity cancer to anti-CD155 therapy. Here, we report O-TPNVs, TIGIT-expressing cell membrane platelet fusion nanovesicles (TPNVs) loaded OXA. Platelet-derived components enable O-TPNVs target wounds interact circulating tumor cells (CTCs). OXA directly kills residual CTCs, induces immunogenic death, activates the immune system. TPNVs bind CD155 on cells, block CD155/TIGIT pathway, restore CD8 + T activity. In vivo analyses reveal achieve synergistic chemotherapeutic immunotherapeutic effects, effectively inhibiting triple-negative breast (4T1) after surgery.

Language: Английский

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Boosting Ferroptosis Therapy with Iridium Single‐Atom Nanocatalyst in Ultralow Metal Content

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(17)

Published: Jan. 31, 2023

Nanocatalysts are promising tumor therapeutics due to their ability induce reactive oxygen species in the microenvironment. Although increasing metal loading can improve catalytic activity, quandary of high content versus potential systemic biotoxicity remains challenging. Here, a fully exposed active site strategy by site-specific anchoring single iridium (Ir) atoms on outer surface nitrogen-doped carbon composite (Ir single-atom catalyst (SAC)) is reported achieve remarkable performance at ultralow (≈0.11%). The Ir SAC exhibits prominent dual enzymatic activities mimic peroxidase and glutathione peroxidase, which catalyzes conversion endogenous H2 O2 into •OH acidic TME depletes (GSH) simultaneously. With an advanced support GSH-trapping platinum(IV) encapsulation with red-blood-cell membrane, this nanocatalytic agent (Pt@IrSAC/RBC) causes intense lipid peroxidation that boosts cell ferroptosis. Pt@IrSAC/RBC demonstrates superior therapeutic efficacy mouse triple-negative mammary carcinoma model, resulting complete ablation treatment session negligible side effects. These outcomes may provide valuable insights design nanocatalysts biosafety for biomedical applications.

Language: Английский

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