Renal‐Clearable Nickel‐Doped Carbon Dots with Boosted Photothermal Conversion Efficiency for Multimodal Imaging‐Guided Cancer Therapy in the Second Near‐Infrared Biowindow

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(26)

Published: April 21, 2021

Abstract Photothermal agents with absorption in the second near‐infrared (NIR‐II) biowindow have attracted increasing attention for photothermal therapy (PTT) on account of their deeper tissue penetration capacity. However, most current NIR‐II exhibit low conversion efficiency (PCE) and long‐term biotoxicity. To overcome these shortcomings, herein, nickel nitrogen co‐doped carbon dots (Ni‐CDs, ≈4.6 nm) are prepared via a facile one‐pot hydrothermal approach imaging‐guided PTT window. The Ni‐CDs significant region distinguished PCE as high 76.1% (1064 excellent photostability biocompatibility. Furthermore, can be employed photothermal, photoacoustic, magnetic resonance imaging contrast because outstanding effect instinctive paramagnetic feature. demonstrate efficacy tumor upon 1064 nm irradiation power density (0.5 W cm −2 ). eliminated from body renal filtration pathway, thereby minimizing Therefore, this work provides simple feasible to develop remarkable region, presenting good biosafety multimodal tumor.

Language: Английский

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Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(21)

Published: April 19, 2021

Abstract Pancreatic cancer, one of the most lethal malignancies, compromises performance traditional therapeutic regimens in clinic because stromal resistance to systemic drug delivery and poor prognosis caused by tumor metastasis. Therefore, a biocompatible paradigm that can effectively inhibit pancreatic growth while simultaneously eliminating metastasis is urgently needed. Herein, supramolecular nanofibrils are fabricated through coassembly clinically approved immunomodulatory thymopentin near‐infrared indocyanine green for localized photothermal immunotherapy tumors. The resulting long‐range ordered fibrous nanodrugs show improved photophysical capabilities fluorescence imaging conversion significantly promote proliferation differentiation antitumor immune cells. Hence, integration rapid therapy moderate immunomodulation inhibiting promising. utilization molecules construct administered via injection amplifies complementary immunotherapeutic effects components, creating opportunities clinical translation as treatment cancer.

Language: Английский

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A Tumor-Targeting Near-Infrared Heptamethine Cyanine Photosensitizer with Twisted Molecular Structure for Enhanced Imaging-Guided Cancer Phototherapy

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(49), P. 20828 - 20836

Published: Dec. 3, 2021

In recent years, cancer phototherapy has been extensively studied as noninvasive treatment. To present efficient recognition toward cells, most photosensitizers (PSs) are required to couple with tumor-targeted ligands. Interestingly, the heptamethine cyanine IR780 displays an intrinsic feature even without modification. However, photothermal efficacy and photostability of not sufficient enough for clinical use. Herein, we involve a twisted structure tetraphenylethene (TPE) between two molecules improve conversion efficiency (PCE). The obtained molecule T780T shows strong near-infrared (NIR) fluorescence improved PCE (38.5%) in dispersed state. Also, stability ROS generation capability at NIR range (808 nm) both promoted. aqueous phase, was formulated into uniform nanoaggregates (∼200 extremely low PTT response, which would reduce vivo imaging background side effect response normal tissues. After intravenous injection tumor-bearing mice, display high tumor accumulation thus remarkably inhibit growth. Moreover, enhanced allows twice irradiation after one leads more significant inhibition. summary, our study presents small-molecule PS therapy brings new design potential applications.

Language: Английский

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BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(18)

Published: Nov. 18, 2022

Abstract The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, inspiring cutting‐edge work post‐functionalization highlighted. A brief overview assembly model BODIPY then provided: introduced as a promising building block for the formation single‐ multicomponent self‐assembled systems, including nanostructures suitable aqueous environments, thereby showing great development potential supramolecular applications. frontier progress biomedical application thereafter described, supported by examples frontiers applications BODIPY‐containing smart materials: it mainly involves materials based on blocks their assemblies fluorescence bioimaging, photoacoustic imaging, disease treatment photodynamic therapy, photothermal immunotherapy. Lastly, not only current status family field but also challenges worth considering summarized. At same time, insights into future prospects biomedically applicable provided.

Language: Английский

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Molecular Motion and Nonradiative Decay: Towards Efficient Photothermal and Photoacoustic Systems

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(30)

Published: May 11, 2022

Nonradiative decay invariably competes with radiative during the deexcitation process of matter. In community luminescence research, nonradiative has been deemed less attractive than decay. However, all things in their being are good for something and so is As molecular motion-facilitated (MMFND) effect inevitable photophysical processes, it provides a new avenue to convert harvested light energy into exploitable forms by harnessing motion. many cases, active motion enables thermal deactivation from excited states. this Minireview, recent advances photothermal photoacoustic systems MMFND character summarized. We believe that presentation rational engineering efficient generation will deepen understanding relationship between navigate people rethink positive aspects establishment light-controllable techniques.

Language: Английский

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Self-Propelled Active Photothermal Nanoswimmer for Deep-Layered Elimination of Biofilm In Vivo

Nano Letters, Journal Year: 2020, Volume and Issue: 20(10), P. 7350 - 7358

Published: Aug. 28, 2020

Increasing penetration of antibacterial agents into biofilm is a promising strategy for improvement therapeutic effect and slowdown the progression antibiotic resistance. Herein, we design near-infrared (NIR) light-driven nanoswimmer (HSMV). Under NIR light irradiation, HSMV performs efficient self-propulsion penetrates within 5 min due to photothermal conversion asymmetrically distributed AuNPs. The localized thermal (∼45 °C) thermal-triggered release vancomycin (Van) leads an combination therapy chemotherapy in one system. active motion increases effective distance (PTT) also improves index antibiotic, resulting superior removal rate (>90%) vitro. Notably, can eliminate S. aureus biofilms grown vivo under 10 laser irradiation without damage healthy tissues. This work may shed on strategies treatment biofilm-associated infections.

Language: Английский

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Amino‐Acid‐Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(16)

Published: Feb. 18, 2022

Photothermal nanomedicine based on self-assembly of biological components, with excellent biosafety and customized performance, is vital significance for precision cancer therapy. However, the programmable design photothermal remains extremely challenging due to vulnerability variability noncovalent interactions governing supramolecular self-assembly. Herein, it reported that amino acid encoding a facile potent means construct nanodrugs controlled therapeutic activities. It found amount type dominates assembled nanostructures, structural stability, energy-conversion pathway, mechanism resulting nanodrugs. Two optimized are endowed robust integrity against disassembly along high conversion efficiency, efficient cellular internalization, enhanced tumor accumulation, which result in more ablation. This work demonstrates offers an unprecedented opportunity construction remarkable photoactive nanomedicines toward diagnostics therapeutics.

Language: Английский

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Organic dye assemblies with aggregation‐induced photophysical changes and their bio‐applications

Aggregate, Journal Year: 2021, Volume and Issue: 2(4)

Published: Feb. 23, 2021

Abstract Phototheranostics provide a safe, effective, and noninvasive way for the diagnosis treatment of contemporary diseases, organic dyes play vital role. For example, chemical modification endowed with powerful reactive oxygen species or heat generation ability, favoring photodynamic therapy photoacoustic (PA) imaging guided photothermal (PTT) serious diseases. Therefore, photophysical properties manipulation has become focus in current dye chemistry research. The development aggregate science made great effort to solve this problem. In recent years, large number studies have focused on molecular aggregation behavior its effect performance. most famous example is discovery aggregation‐induced emission (AIE) phenomenon. Based AIE theory, more theories revealing relationship between were proposed elucidated. property changes caused by unique discipline, guiding material science. With help self‐assembly, controllable can be realized, stable nano‐theranostic reagents obtained. Furthermore, constructing assemblies various will greatly reduce cost theranostic reagents, thus, expanding biomedical applications dyes. review focuses characteristic their biological including, fluorescence/phosphorescence/PA as well PTT. This guidance design dyes, methods, construction multifunctional phototheranostic reagents.

Language: Английский

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Organic Photo-antimicrobials: Principles, Molecule Design, and Applications

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(43), P. 17891 - 17909

Published: Oct. 22, 2021

The emergence of multi-drug-resistant pathogens threatens the healthcare systems world-wide. Recent advances in phototherapy (PT) approaches mediated by photo-antimicrobials (PAMs) provide new opportunities for current serious antibiotic resistance. During PT treatment, reactive oxygen species or heat produced PAMs would react with cell membrane, consequently leaking cytoplasm components and effectively eradicating different like bacteria, fungi, viruses, even parasites. This Perspective will concentrate on development organic (OPAMs) their application as practical therapeutic agents into therapy local infections, wound dressings, removal biofilms from medical devices. We also discuss how to design highly efficient OPAMs modifying chemical structure conjugating a targeting component. Moreover, this provides discussion general challenges direction what further needs be done. It is hoped that through overview, can prosper more widely used microbial infections future, especially at time when global COVID-19 epidemic getting serious.

Language: Английский

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MXene materials for advanced thermal management and thermal energy utilization

Nano Energy, Journal Year: 2022, Volume and Issue: 97, P. 107177 - 107177

Published: March 26, 2022

Language: Английский

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