Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(27)

Published: March 28, 2022

Abstract Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed prepared based on benzo[ c ]thiophene unit as building block; it can be used for simultaneous fluorescence imaging (FLI) in second near‐infrared (NIR‐II) window, photoacoustic (PAI), (PTI), thermal eradication of Further experiments validate that therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys primary tumor but also enhances immunogenicity further suppressing growth at distant sites. Furthermore, PTT combining programmed death‐ligand 1 (PD‐L1) antibody prevents metastasis recurrence cancer potentiating effect immunotherapy.

Language: Английский

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Injectable Adhesive Self-Healing Multiple-Dynamic-Bond Crosslinked Hydrogel with Photothermal Antibacterial Activity for Infected Wound Healing

Chemistry of Materials, Journal Year: 2022, Volume and Issue: 34(6), P. 2655 - 2671

Published: March 10, 2022

The development of multifunctional injectable adhesive hydrogels with self-healing capacity, shape adaptability, on-demand removability, and excellent photothermal antibacterial activity to promote bacteria-infected wound healing is highly recommended in practical applications. In this work, an multiple-dynamic-bond crosslinked hydrogel was formed by a network dynamic borate/didiol interactions, hydrogen bonding, Schiff base bond. introduction Mussel-inspired catechol groups into the could endow tissues properties, adhere well skin under water good adaptability bent twisted states. mechanical properties improved through interactions catechol-modified crosslinking at low cost easy preparation, be removed without second damage wound. Moreover, polydopamine nanoparticles (PDA NPs) were introduced reactions between quinone group on PDA NPs primary amine glycol chitosan (GC), resulting efficient uniformly dispersed hydrogel. And illustrated cytocompatibility hemocompatibility. Finally, they injected fully fill irregular wounds significantly reducing inflammatory response, accelerating collagen deposition, promoting blood vessel reconstruction. Therefore, demonstrated their superiority serving as dressings for treating

Language: Английский

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Amino‐Acid‐Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(16)

Published: Feb. 18, 2022

Photothermal nanomedicine based on self-assembly of biological components, with excellent biosafety and customized performance, is vital significance for precision cancer therapy. However, the programmable design photothermal remains extremely challenging due to vulnerability variability noncovalent interactions governing supramolecular self-assembly. Herein, it reported that amino acid encoding a facile potent means construct nanodrugs controlled therapeutic activities. It found amount type dominates assembled nanostructures, structural stability, energy-conversion pathway, mechanism resulting nanodrugs. Two optimized are endowed robust integrity against disassembly along high conversion efficiency, efficient cellular internalization, enhanced tumor accumulation, which result in more ablation. This work demonstrates offers an unprecedented opportunity construction remarkable photoactive nanomedicines toward diagnostics therapeutics.

Language: Английский

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Photothermal conversion and transfer in photothermal therapy: From macroscale to nanoscale

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 308, P. 102753 - 102753

Published: Aug. 16, 2022

Photothermal therapy (PTT) is a promising alternative for benign or even malignant tumors. To improve the selective heating of tumor cells, target-specific photothermal conversion agents are often included, especially nanoparticles. Meanwhile, some indirect methods by manipulating radiation and heat delivery also adopted. Therefore, to gain clear understanding mechanism, controllability PTT, few issues need be clarified, including bioheat transfer, localized collective nanoparticles, etc. In this review, we provide an introduction typical transfer models along with dynamic thermophysical properties biological tissue. On basis, reviewed most recent advances in temperature control PTT from macroscale nanoscale. Most importantly, comprehensive effects nanoparticle clusters provided give insight into mechanism PPT microscale nanoscale point view.

Language: Английский

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Functional chromopeptide nanoarchitectonics: molecular design, self-assembly and biological applications

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(8), P. 2688 - 2712

Published: Jan. 1, 2023

An overview of chromopeptide self-assembly is presented to systematically understand this kind newly emerging peptide building block.

Language: Английский

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Semiconducting Polymer Nanoparticles with Surface‐Mimicking Protein Secondary Structure as Lysosome‐Targeting Chimaeras for Self‐Synergistic Cancer Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(31)

Published: June 15, 2022

Immunotherapy has received tremendous attention for tumor treatment, but the efficacy is greatly hindered by insufficient tumor-infiltration of immune cells and immunosuppressive microenvironment. The strategy that can efficiently activate cytotoxic T lymphocytes inhibit negative regulators will amplify immunotherapy outcome, which however very rare. Herein, a new kind semiconducting polymer (SP) nanoparticles developed, featured with surface-mimicking protein secondary structure (SPSS NPs) self-synergistic cancer combining immunogenic cell death (ICD) checkpoint blockade therapy. SPs excellent photodynamic property are synthesized rational fluorination, massively induce ICD. Additionally, peptide antagonists introduced self-assembled into β-sheet structures on NP surface via preparation process optimization, function as efficient lysosome-targeting chimaeras (LYTACs) to mediate degradation programmed ligand-1 (PD-L1) in lysosome. In vivo experiments demonstrate SPSS NPs not only elicit strong antitumor immunity suppress both primary distant tumor, also evoke long-term immunological memory against rechallenge. This work introduces robust agents well-designed photosensitizer-based ICD induction structures-mediated LYTAC-like multivalence PD-L1 blockade, rendering great promise synergistic immunotherapy.

Language: Английский

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Tailoring supramolecular short peptide nanomaterials for antibacterial applications

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 460, P. 214481 - 214481

Published: Feb. 24, 2022

Language: Английский

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A bimetallic nanoplatform for STING activation and CRISPR/Cas mediated depletion of the methionine transporter in cancer cells restores anti-tumor immune responses

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 2, 2023

Abstract Lack of sufficient cytotoxic T lymphocytes (CD8 + cells) infiltration and dysfunctional state CD8 cells are considered enormous obstacles to antitumor immunity. Herein, we construct a synergistic nanoplatform promote cell in tumors while restoring function by regulating methionine metabolism activating the STING innate immune pathway. The CRISPR/Cas9 system down-regulates transporter SLC43A2 restricts uptake tumor cells, thereby relieving competition pressure cells; simultaneously, released nutrition metal ions activate cGAS/STING In this work, described can enhance effect immunotherapy preclinical cancer models female mice, enhancing pathway mediated immunity facilitating development amino acid metabolic intervention-based therapy.

Language: Английский

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Integrating Bacteria with a Ternary Combination of Photosensitizers for Monochromatic Irradiation-Mediated Photoacoustic Imaging-Guided Synergistic Photothermal Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 5059 - 5071

Published: Feb. 27, 2023

Photosensitizer-based therapy often suffers from unitary and easily attenuated photosensitive effects, limited tumor penetration retention, requirement of multiple irradiation for combination therapy, which largely restrict its application. Here, bacteria are integrated with a monochromatic irradiation-mediated ternary photosensitizers photoacoustic imaging-guided synergistic photothermal therapy. Bacteria that bioengineered to express natural melanin decorated dual synthetic by nanodeposition indocyanine green polydopamine under cytocompatible condition. The combined photosensitizers, share an adequate excitation at 808 nm, endow stable triple effect irradiation. Due their living characteristics, these preferentially colonize hypoxic tissue homogeneous distribution durable retention generate uniform imaging signals sufficient heating upon laser Supported significantly inhibited growth extended survival animals in different tumor-bearing murine models, our work proposes the development bacteria-based innovative

Language: Английский

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Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme‐Mediated Catalytic/Starvation/Mild‐Temperature Photothermal Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(22)

Published: March 25, 2023

Reactive oxygen species (ROS)-mediated tumor catalytic therapy is typically hindered by gap junction proteins that form cell-to-cell channels to remove cytotoxic ROS, thereby protecting cells from oxidative damage. In this work, a multifunctional nanozyme, FePGOGA, designed and prepared Fe(III)-mediated polymerization (FeP), followed glucose oxidase (GOx) GAP19 peptides co-loading through electrostatic π-π interactions. The FePGOGA nanozyme exhibits excellent cascade peroxidase- glutathione-oxidase-like activities efficiently catalyze hydrogen peroxide conversion hydroxyl radicals convert reduced glutathione oxidized disulfide. loaded GOx starves the tumors aggravates stress decomposition, while block hemichannels inducing degradation of Cx43, thus increasing accumulation intracellular decreasing transport glucose. Furthermore, ROS reacts with primary amines heat shock destroy their structure function, enabling photothermal at widely sought-after mild temperature (mildPTT, ≤45 °C). vivo experiments demonstrate significant antitumor effectof on cal27 xenograft under near-infrared light irradiation. This study demonstrates successful ablation overcome resistance ROS-mediated therapy, providing regulator suppress self-preservation during starvation, mildPTT.

Language: Английский

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