Biomaterial-assisted biotherapy: A brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 29 - 48

Published: Jan. 19, 2022

Biotherapy has recently become a hotspot research topic with encouraging prospects in various fields due to wide range of treatments applications, as demonstrated preclinical and clinical studies. However, the broad applications biotherapy have been limited by critical challenges, including lack safe efficient delivery systems serious side effects. Due unique potentials biomaterials, such good biocompatibility bioactive properties, biomaterial-assisted be an attractive strategy. The biomaterial-based possess sufficient packaging capacity versatile functions, enabling sustained localized release drugs at target sites. Furthermore, biomaterials can provide niche specific extracellular conditions for proliferation, differentiation, attachment, migration stem cells, leading tissue regeneration. In this review, state-of-the-art studies on biotherapy, drug delivery, vaccine development, gene therapy, cell summarized. challenges outlook biotherapies also discussed.

Language: Английский

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Antimicrobial peptide-based materials: opportunities and challenges

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(14), P. 2384 - 2429

Published: Jan. 1, 2022

The design of antimicrobial peptide-based materials for biomedical applications such as fighting infections in various organs, cancer therapy, gene delivery and detection bacteria.

Language: Английский

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Diabetes mellitus and diabetic foot ulcer: Etiology, biochemical and molecular based treatment strategies via gene and nanotherapy

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 151, P. 113134 - 113134

Published: May 24, 2022

Diabetes mellitus (DM) is a collection of metabolic and pathophysiological disorders manifested with high glucose levels in the blood due to inability β-pancreatic cells secrete an adequate amount insulin or insensitivity towards receptor oxidize glucose. Nevertheless, preceding definition only applicable people who do not have inherited disorders. Suppose person has been diagnosed Type 1 2DM sustains injury treatment damage complicated prolonged. In that case, referred as diabetic foot ulcer (DFU). presence many proliferating macrophages site for extended period causes worsen become wound. this review, scientific information therapeutic management DM/DFU nanomedicine, other related data were collected (Web Science PubMed) from January 2000 2022. Most articles revealed standard drugs are usually prescribed along hypoglycaemic medications. Conversely, such stabilize transporters homeostasis limited period, resulting side effects kidney damage/failure, absorption/gastrointestinal problems, hypoglycemic issues. paper, we review current basic clinical evidence about potential medicinal plants, gene therapy, chemical/green synthesized nanoparticles improving profile, facilitating DM DFU associated complications. Preclinical studies also reported lower plasma molecular targets DFU. Research underway explore nanoparticle-based medications avoid effects. Hence, present intended address challenges, recently recognized factors responsible DFU, their pathophysiology, receptors DM, trend,

Language: Английский

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Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives

The Innovation, Journal Year: 2023, Volume and Issue: 4(6), P. 100503 - 100503

Published: Aug. 29, 2023

•Insights into the intricate facets of immune microenvironment hold key to pioneering clinical strategies in combatting bacterial infections.•The design principles for antimicrobial biomaterials vary depending on at different stages infection.•Immunomodulatory display robust efficacy and vaccine attributes animals trials, promising intractable infections. Bacterial infectious diseases are one leading causes death worldwide. Even with use multiple antibiotic treatment strategies, 4.95 million people died from drug-resistant infections 2019. By 2050, number deaths will reach 10 annually. The increasing mortality may be partly due heterogeneity infection microenvironment, such as bacteria, biofilms, persister cells, intracellular small colony variants. In addition, complexity makes direct activity unsatisfactory long-term chronic attributed failing modulate active action cells. Therefore, there is an urgent need effective alternatives treat Accordingly, development immunomodulatory has recently received considerable interest; however, a comprehensive review their research progress lacking. this review, we focus mainly future perspectives used infection. First, describe characteristics acute phases Then, highlight corresponding advantages disadvantages. Moreover, discuss biomaterial-mediated vaccines' potential applications challenges activating innate adaptive memory. This serve reference studies develop next-generation accelerate translation practice.

Language: Английский

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Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Language: Английский

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Mechanochemically Reprogrammed Interface Orchestrates Neutrophil Bactericidal Activity and Apoptosis for Preventing Implant‐Associated Infection

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(16)

Published: Jan. 2, 2024

Abstract The onset of implant‐associated infection (IAI) triggers a cascade immune responses, which are initially dominated by neutrophils. Bacterial aggregate formation and hypoxic microenvironment, occur shortly after implantation, may be two major risk factors that impair neutrophil function lead to IAI. Here, the implant surface with phytic acid–Zn 2+ coordinated TiO 2 nanopillar arrays (PA–Zn@TiNPs) oxygen self‐supporting CaO nanoparticles, named as CPZTs, is mechanochemically reprogrammed. engineered CPZTs interface integrates multiple properties inhibit nascent biofilm, encompassing antibacterial adhesion, mechanobactericidal effect, chemobiocidal effect. Meanwhile, continuous oxygenation fuels neutrophils reactive species (ROS) for efficient bacterial elimination on inside Furthermore, this modulation strategy accelerates apoptosis promotes M2 macrophage‐mediated osteogenesis both in vitro rat model In conclusion, targeting immunomodulation practical effective prevent IAI promote bone–implant integration.

Language: Английский

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Dopamine-mediated copper-loaded ZnTiO3 antimicrobial coating with immunomodulatory properties effectively enhances vascularised osteogenesis on titanium implants

Journal of Industrial and Engineering Chemistry, Journal Year: 2024, Volume and Issue: 135, P. 94 - 109

Published: Jan. 10, 2024

Language: Английский

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Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation

Biomaterials, Journal Year: 2024, Volume and Issue: 307, P. 122515 - 122515

Published: Feb. 21, 2024

Language: Английский

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Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 49 - 49

Published: Jan. 2, 2025

Biofilms, composed of structured communities bacteria embedded in a self-produced extracellular matrix, pose significant challenge due to their heightened resistance antibiotics and immune responses. This review highlights the mechanisms underpinning antibiotic within bacterial biofilms, elucidating adaptive strategies employed by microorganisms withstand conventional antimicrobial agents. encompasses role altered gene expression, formation persister cells, contributing recalcitrance biofilms eradication. A comprehensive understanding these provides for exploring innovative therapeutic interventions. study explores promising avenues future research, emphasizing necessity uncovering specific genetic phenotypic adaptations occurring biofilms. The identification vulnerabilities biofilm architecture elucidation key biofilm-specific targets emerge as crucial focal points development targeted strategies. In addressing limitations traditional antibiotics, this discusses approaches. Nanomaterials with inherent properties, quorum-sensing inhibitors disrupting communication, bacteriophages viral agents are highlighted potential alternatives. exploration combination therapies, involving agents, biofilm-disrupting enzymes, immunomodulators, is emphasized enhance efficacy existing treatments overcome resilience.

Language: Английский

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Piezoelectric Biomaterial with Advanced Design for Tissue Infection Repair

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract Bacterial infection has become the most dangerous factor in tissue repair, which strongly affects regeneration efficiency and wellness of patients. Piezoelectric materials exhibit outstanding advantage producing electrons without external power supply. The ability electron enrichment reactive oxygen species generation through noninvasive stimulations enables piezoelectric potential applications antibacterial. Many studies have proved feasibility as a functional addition antibacterial biomaterial. In fact, numerous with ingenious designs are reported to be effective processes. This review summarizes mechanisms piezoelectric, illuminating their combating bacteria. Recent advancement design construction biomaterial including defect engineering, heterojunction, synergy metal composite scaffold configuration thoroughly reviewed. Moreover, therapeutic effects common tissues requirements introduced, such orthopedics, dental, wound healing. Finally, development prospects points deserving further exploration listed. is expected provide valuable insight into relationship between processes materials, inspiring constructive this emerging scientific discipline.

Language: Английский

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