Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(6)
Published: Jan. 3, 2023
Abstract
Covalent
organic
frameworks
(COFs)
have
attracted
increasing
attention
for
biomedical
applications.
COFs‐based
nanosensitizers
with
uniform
nanoscale
morphology
and
tumor‐specific
curative
effects
are
in
high
demand;
however,
their
synthesis
is
yet
challenging.
In
this
study,
distinct
COF
nanobowls
synthesized
a
controlled
manner
engineered
as
activatable
sonodynamic
activity.
High
crystallinity
ensures
an
ordered
porous
structure
of
the
efficient
loading
small‐molecule
sonosensitizer
rose
bengal
(RB).
To
circumvent
non‐specific
damage
to
normal
tissues,
sonosensitization
effect
specifically
inhibited
by
situ
growth
manganese
oxide
(MnO
x
)
on
RB‐loaded
COFs.
Upon
reaction
tumor‐overexpressed
glutathione
(GSH),
“gatekeeper”
MnO
rapidly
decomposed
recover
reactive
oxygen
species
(ROS)
generation
capability
under
ultrasound
irradiation.
Increased
intracellular
ROS
stress
GSH
consumption
concomitantly
induce
ferroptosis
improve
efficacy.
Additionally,
unconventional
bowl‐shaped
renders
enhanced
tumor
accumulation
retention.
The
combination
therapy
achieves
efficacy
killing
cancer
cells
inhibiting
growth.
This
study
paves
way
development
morphologies
biomedicine,
offering
paradigm
realize
ferroptosis‐augmented
therapy.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(6), P. 6514 - 6613
Published: Feb. 8, 2022
A
grand
family
of
two-dimensional
(2D)
materials
and
their
heterostructures
have
been
discovered
through
the
extensive
experimental
theoretical
efforts
chemists,
material
scientists,
physicists,
technologists.
These
pioneering
works
contribute
to
realizing
fundamental
platforms
explore
analyze
new
physical/chemical
properties
technological
phenomena
at
micro-nano-pico
scales.
Engineering
2D
van
der
Waals
(vdW)
via
chemical
physical
methods
with
a
suitable
choice
stacking
order,
thickness,
interlayer
interactions
enable
exotic
carrier
dynamics,
showing
potential
in
high-frequency
electronics,
broadband
optoelectronics,
low-power
neuromorphic
computing,
ubiquitous
electronics.
This
comprehensive
review
addresses
recent
advances
terms
representative
materials,
general
fabrication
methods,
characterization
techniques
vital
role
parameters
affecting
quality
heterostructures.
The
main
emphasis
is
on
3D-bulk
(3D)
hybrid
systems
exhibiting
intrinsic
quantum
mechanical
responses
optical,
valley,
topological
states.
Finally,
we
discuss
universality
applications
trends
for
future
electronics
optoelectronics
(FEO)
under
challenges
opportunities
from
physical,
nanotechnological,
synthesis
perspectives.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(9), P. 3380 - 3435
Published: Jan. 1, 2022
Piezoelectric
nanogenerators
are
becoming
a
compelling
bioelectronics
platform
technology
for
human-associated
energy
harvesting,
self-powered
sensing,
and
therapeutics,
which
will
largely
contribute
to
the
medical
field
in
era
of
Internet
things.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Sept. 30, 2022
Theranostic
sonosensitizers
with
combined
sonodynamic
and
near
infrared
(NIR)
imaging
modes
are
required
for
guided
therapy
(SDT).
It
is
challenging,
however,
to
realize
a
single
material
that
simultaneously
endowed
both
NIR
emitting
activities.
Herein,
we
report
the
design
of
class
NIR-emitting
from
phosphorescent
carbon
dot
(CD)
narrow
bandgap
(1.62
eV)
long-lived
excited
triplet
states
(11.4
μs),
two
which
can
enhance
SDT
as
thermodynamically
dynamically
favorable
factors
under
low-intensity
ultrasound
irradiation,
respectively.
The
NIR-phosphorescent
CDs
identified
bipolar
quantum
dots
containing
p-
n-type
surface
functionalization
regions
drive
spatial
separation
e--h+
pairs
fast
transfer
reaction
sites.
Importantly,
cancer-specific
targeting
high-level
intratumor
enrichment
theranostic
achieved
by
cancer
cell
membrane
encapsulation
precision
complete
eradication
solid
tumors
injection
irradiation.
These
results
will
open
up
promising
approach
engineer
materials
tumor
therapy.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(25)
Published: Jan. 12, 2023
Abstract
Emerging
piezocatalysts
have
demonstrated
their
remarkable
application
potential
in
diverse
medical
fields.
In
addition
to
ultrahigh
catalytic
activities,
inherent
and
unique
charge‐carrier‐releasing
properties
can
be
used
initiate
various
redox
reactions,
displaying
bright
prospects
for
future
applications.
Triggered
by
mechanical
energy,
piezocatalytic
materials
release
electrons/holes,
catalyze
reactions
of
substrates,
or
intervene
biological
processes
promote
the
production
effector
molecules
purposes,
such
as
decontamination,
sterilization,
therapy.
Such
a
piezocatalysis
is
termed
medicine
(PCM)
herein.
To
pioneer
novel
technologies,
especially
therapeutic
modalities,
this
review
provides
an
overview
state‐of‐the‐art
research
progress
medicine.
First,
principle
preparation
methodologies
piezoelectric
are
introduced.
Then,
comprehensive
summary
applications
tumor
treatment,
antisepsis,
organic
degradation,
tissue
repair
regeneration,
biosensing
provided.
Finally,
main
challenges
perspectives
discussed
proposed,
expecting
fuel
development
emerging
scientific
discipline.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(6), P. 9304 - 9316
Published: June 14, 2022
Ultrasound
(US)-triggered
sonodynamic
therapy
(SDT)
based
on
semiconductor
nanomaterials
has
attracted
considerable
attention
for
cancer
therapy.
However,
most
inorganic
sonosensitizers
suffer
from
low
efficiency
due
to
the
rapid
recombination
of
electron-hole
pairs.
Herein,
Cu2-xO-BaTiO3
piezoelectric
heterostructure
was
fabricated
as
a
sonosensitizer
and
chemodynamic
agent,
simultaneously,
improving
reactive
oxygen
species
(ROS)
generation
therapeutic
outcome.
Under
US
irradiation,
heterojunction
with
piezotronic
effect
exhibits
high-performance
singlet
(1O2)
hydroxyl
radical
(•OH)
enhance
SDT.
Moreover,
it
possesses
Fenton-like
reaction
activity
convert
endogenous
H2O2
into
•OH
(CDT).
The
integration
SDT
CDT
substantially
boosts
ROS
cellular
mitochondria
damage,
in
vitro
vivo
results
demonstrate
high
cytotoxicity
tumor
inhibition
murine
refractory
breast
cancer.
This
work
realizes
improvement
using
heterostructures
effects.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(44)
Published: Sept. 9, 2022
Abstract
Owing
to
the
high
depth
of
tissue
penetration,
non‐invasiveness,
and
controllability,
ultrasound
(US)‐mediated
sonodynamic
therapy
(SDT)
has
shown
broad
application
prospects
for
tumor
treatment.
However,
electron‐hole
separation
inefficiency
sonosensitizers
hypoxia
remain
two
major
challenges
limiting
effect
SDT.
Here,
ultrafine
photoetched
bismuth
vanadate
(BiVO
4
)
nanorods
modified
with
DSPE‐PEG
2000
(PEBVO@PEG
NRs)
were
fabricated
achieve
in
situ
self‐supply
oxygen
(O
2
reactive
species
(ROS)
hypoxic
therapy.
The
photoetching
approach
could
enhance
charge
by
inducing
enriched
vacancies
on
surface
BiVO
,
thereby
improving
generation
efficiency
ROS
O
.
PEBVO@PEG
overcome
main
obstacles
traditional
SDT
process
show
promising
therapeutic
effects,
thus
providing
new
strategies
performance
sonosensitizer
elimination.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(7)
Published: Nov. 22, 2022
Overcoming
apoptosis
resistance
to
achieve
efficient
breast
cancer
treatment
remains
a
challenge.
The
precise
induction
of
another
form
programmed
cell
death,
pyroptosis,
is
an
excellent
alternative
for
treating
cancer.
Ultrasound
(US)-enhanced
enzyme
dynamic
(enzyodynamic)
therapy
developed
by
employing
LaFeO3
(LFO)
perovskite
nanocrystals
as
substrate
increase
the
rate
deleterious
reactive
oxygen
species
(ROS)
generation
intensive
pyroptosis.
LFO
possess
quadruple
enzyme-mimicking
activities,
including
oxidase-,
peroxidase-,
glutathione
and
catalase-mimicking
which
undertake
dominant
therapeutic
task
through
cascade
catalytic
reactions,
reversal
hypoxic
microenvironment,
depletion
endogenous
glutathione,
continuous
output
ROS.
US
exogenous
stimulation
increases
transition
intermediate
complex
Fe
(II)
favors
incremental
ROS
production,
burst-induced
pyroptosis
process
accomplished
ROS-TXNIP-NLRP3-GSDMD
pathway.
Both
in
vitro
vivo
antineoplastic
outcomes
affirm
ascendancy
nanozyme-induced
This
work
highlights
critical
role
coupled
with
nanocatalytic
reactors
pyroptosis-dominant
circumvention
feature.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(8), P. 7901 - 7910
Published: April 13, 2023
The
regulation
of
electrostatic
electric
fields
through
electrical
stimulation
is
an
efficient
method
to
increase
the
catalytic
activity
nanozymes
and
improve
therapeutic
effect
nanozyme
therapy.
Piezoelectric
materials,
which
are
capable
generating
a
built-in
field
under
ultrasound
(US),
not
only
but
also
enable
piezoelectric
sonodynamic
therapy
(SDT).
In
this
study,
sonosensitizer
based
on
Hf-based
metal–organic
framework
(UIO-66)
Au
nanoparticles
(NPs)
was
produced.
Under
US
irradiation,
UIO-66
can
generate
inside
promotes
electron–hole
separation
produces
reactive
oxygen
species
(ROS).
introduction
NPs
facilitated
electron
transfer,
inhibited
recombination
pairs
improved
properties
UIO-66.
value
constant
(d33)
increased
from
71
122
pmV–1
after
deposition
NPs.
addition,
intrinsic
catalase
peroxidase
activities
were
2-fold
induced
exposure.
vivo
in
vitro
experiments
revealed
that
proposed
kill
cancer
cells
inhibit
tumor
growth
mice
enhanced
SDT
sensitizer
work
proved
be
candidate
used
for
multiple
modalities
