All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: March 2, 2023

Abstract Macrophages are highly heterogeneous and exhibit a diversity of functions phenotypes. They can be divided into pro‐inflammatory macrophages (M1) anti‐inflammatory (M2). Diabetic wounds characterized by prolonged inflammatory phase difficulty in healing due to the accumulation wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise promoting diabetic wound clinical applications. However, precise conversion M1 M2 simple biosafe approaches is still challenge. Here, an all‐natural ability regulate developed promote angiogenesis healing. The protocatechuic aldehyde hybridized collagen‐based exhibits good bioadhesive antibacterial properties as well reactive oxygen species scavenging ability. More importantly, able convert without need for any additional ingredients or external intervention. This safe immunomodulatory approach shows application potential shortening repair accelerating

Language: Английский

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Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing

Advanced Science, Journal Year: 2023, Volume and Issue: 10(11)

Published: Feb. 12, 2023

Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use antibiotics for infected management. Hence, a versatile hydrogel (rGB/QCS/PDA-PAM) skin adaptiveness on dynamic wounds and mild photothermal is developed safe efficient treatment. Phenylboronic acid-functionalized graphene (rGB) oxadiazole-decorated quaternary carboxymethyl chitosan (QCS) are incorporated into polydopamine-polyacrylamide (PDA-PAM) network with multiple covalent noncovalent bonds, which conferred flexible mechanical properties, strong tissue adhesion excellent self-healing ability wounds. Moreover, glycocalyx-mimicking phenylboronic acid surface rGB enables specifically capture bacteria. The enhanced membrane permeability QCS bacterial vulnerability therapy（PTT）, demonstrated by PTT antibacteria against methicillin-resistant Staphylococcus aureus in vitro vivo at temperatures <49.6 °C. Consequently, demonstrate accelerated regeneration MRSA-infected vivo, an intact epidermis, abundant collagen deposition prominent angiogenesis. Therefore, rGB/QCS/PDA-PAM inherent has considerable potential treating drug-resistant

Language: Английский

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Bioinspired polydopamine hydrogels: Strategies and applications

Progress in Polymer Science, Journal Year: 2023, Volume and Issue: 146, P. 101740 - 101740

Published: Sept. 17, 2023

Language: Английский

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Smart polydopamine-based nanoplatforms for biomedical applications: state-of-art and further perspectives

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 488, P. 215153 - 215153

Published: April 27, 2023

Language: Английский

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Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Dec. 1, 2022

Bone degeneration associated with various diseases is increasing due to rapid aging, sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical remodeling, under pathological conditions results in significant changes these properties. There growing interest utilizing biomimetic electroactive biomaterials that recapitulate the natural electrophysiological microenvironment of healthy promote repair. This review first summarizes etiology degenerative such as type II diabetes, osteoporosis, periodontitis, osteoarthritis, rheumatoid arthritis, osteomyelitis, metastatic osteolysis. Next, diverse array synthetic therapeutic potential are discussed. Putative mechanistic pathways by which can mitigate critically examined, including enhancement osteogenesis angiogenesis, suppression inflammation osteoclastogenesis, well their anti-bacterial effects. Finally, limited research on utilization treatment aforementioned examined. Previous studies have mostly focused using treat traumatic injuries. It hoped this will encourage more efforts use for treating conditions.

Language: Английский

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Oral polyphenol-armored nanomedicine for targeted modulation of gut microbiota–brain interactions in colitis

Science Advances, Journal Year: 2023, Volume and Issue: 9(21)

Published: May 26, 2023

Developing oral nanomedicines that suppress intestinal inflammation while modulating gut microbiota and brain interactions is essential for effectively treating inflammatory bowel disease. Here, we report an polyphenol-armored nanomedicine based on tumor necrosis factor-α (TNF-α)-small interfering RNA gallic acid-mediated graphene quantum dot (GAGQD)-encapsulated bovine serum albumin nanoparticle, with a chitosan tannin acid (CHI/TA) multilayer. Referred to "armor," the CHI/TA multilayer resists harsh environment of gastrointestinal tract adheres inflamed colon sites in targeted manner. TA provides antioxidative stress prebiotic activities modulate diverse microbiota. Moreover, GAGQD protected TNF-α-siRNA delivery. Unexpectedly, armored suppressed hyperactive immune responses modulated bacterial homeostasis mouse model acute colitis. Notably, alleviated anxiety- depression-like behaviors cognitive impairment mice This armor strategy sheds light effect microbiome-brain interactions.

Language: Английский

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Stem Cell‐Derived Nanovesicles Embedded in Dual‐Layered Hydrogel for Programmed ROS Regulation and Comprehensive Tissue Regeneration in Burn Wound Healing

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: June 1, 2024

Abstract Burn wounds often bring high risks of delayed healing process and even death. Reactive oxygen species (ROS) play a crucial role in burn wound repair. However, the dynamic requires both generation ROS to inhibit bacteria subsequent reduction levels initiate promote tissue regeneration, which calls for more intelligent regulation dressing system. Hence, dual‐layered hydrogel (Dual‐Gel) tailored repair is designed: inner layer (Gel 2) first responds bacterial hyaluronidase (Hyal) deliver aggregation‐induced emission photosensitizer functionalized adipose‐derived stem cell nanovesicles, generate upon light irradiation eliminate bacteria; then outer 1) continuously starts long‐lasting consumption excess at site accelerate regeneration. Simultaneously, nanovesicles trapped burns also provide nutrients mobilize neighboring tissues thoroughly assist inflammation regulation, proliferation, migration, angiogenesis. In summary, this study develops an treatment approach on by programmatically regulating facilitating comprehensive

Language: Английский

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Bioinspired Piezoelectric Periosteum to Augment Bone Regeneration via Synergistic Immunomodulation and Osteogenesis

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(9), P. 12273 - 12293

Published: Feb. 22, 2023

Ideal periosteum materials are required to participate in a sequence of bone repair-related physiological events, including the initial immune response, endogenous stem cell recruitment, angiogenesis, and osteogenesis. However, conventional tissue-engineered periosteal have difficulty achieving these functions by simply mimicking via structural design or loading exogenous cells, cytokines, growth factors. Herein, we present novel biomimetic preparation strategy comprehensively enhance regeneration effect using functionalized piezoelectric materials. The resulting possessing an excellent improved physicochemical properties was prepared biocompatible biodegradable poly(3-hydroxybutyric acid-co-3-hydrovaleric acid) (PHBV) polymer matrix, antioxidized polydopamine-modified hydroxyapatite (PHA), barium titanate (PBT), which were further incorporated into matrix fabricate multifunctional simple one-step spin-coating method. addition PHA PBT dramatically enhanced biological periosteum, surface hydrophilicity roughness, mechanical performance, tunable degradation behavior, stable desired electrical stimulations, is conducive accelerating regeneration. Benefiting from stimulation bioactive components, as-fabricated demonstrated favorable biocompatibility, osteogenic activity, immunomodulatory vitro, not only promoted adhesion, proliferation, spreading as well osteogenesis mesenchymal cells (MSCs) but also effectively induced M2 macrophage polarization, thereby suppressing reactive oxygen species (ROS)-induced inflammatory reactions. Through vivo experiments, with synergistically accelerated formation new rat critical-sized cranial defect model. whole almost completely covered at 8 weeks post treatment, thickness close that host bone. Collectively, its properties, developed here represents method rapidly regenerate tissue stimulation.

Language: Английский

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Polydopamine-Mediated Immunomodulatory Patch for Diabetic Periodontal Tissue Regeneration Assisted by Metformin-ZIF System

ACS Nano, Journal Year: 2023, Volume and Issue: 17(17), P. 16573 - 16586

Published: Aug. 14, 2023

An essential challenge in diabetic periodontal regeneration is achieving the transition from a hyperglycemic inflammatory microenvironment to regenerative one. Here, we describe polydopamine (PDA)-mediated ultralong silk microfiber (PDA-mSF) and metformin (Met)-loaded zeolitic imidazolate framework (ZIF) incorporated into fibroin/gelatin (SG) patch promote soft hard tissue by regulating immunomodulatory microenvironment. The PDA-mSF endows with reactive oxygen species (ROS)-scavenging ability anti-inflammatory activity, reducing response suppressing M1 macrophage polarization. Moreover, PDA improves ligament reconstruction via its cell affinity. Sustained release of Met Met-ZIF system confers antiaging abilities activating M2 polarization secrete osteogenesis-related cytokines, while Zn2+ also promotes bone regeneration. Consequently, creates favorable for These features synergistically accelerate Thus, our findings offer potential therapeutic strategy periodontitis.

Language: Английский

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Nanomedomics

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 10979 - 11024

Published: April 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Language: Английский

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