Succinate Nanomaterials Boost Tumor Immunotherapy via Activating Cell Pyroptosis and Enhancing MHC-I Expression DOI Creative Commons
Pan Zheng, Guanglei Wang, Bin Liu

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Despite the promising clinical applications of immunotherapy, its effectiveness is often limited by low immune responses and tumor escape. In this study, we introduce a simple drug-free inorganic nanomaterial, sodium succinate (C4H4Na2O4 NPs), prepared using rapid microemulsion method to enhance cancer immunotherapy. The synthesized C4H4Na2O4 NPs can release high concentrations Na+ ions into cells, leading an increase in intracellular osmolarity. This triggers pyroptosis pathway, resulting cellular contents, inflammatory factors, damage-associated molecular patterns, which ultimately boost responses. Furthermore, inhibit escape through upregulating major histocompatibility complex-I (MHC-I) expression. Collectively, significantly growth metastasis pyroptosis-induced activation MHC-I expression upregulation-remitted research offers novel approach treatment that leverages pyroptosis, demonstrating potential for application

Language: Английский

Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy DOI Creative Commons
Shuang Bai,

Yulu Lan,

Shiying Fu

et al.

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: July 18, 2022

As the indispensable second cellular messenger, calcium signaling is involved in regulation of almost all physiological processes by activating specific target proteins. The importance ions (Ca

Language: Английский

Citations

102
Dynamic Assembly of DNA Nanostructures in Living Cells for Mitochondrial Interference DOI
Feng Li, Yujie Liu, Yuhang Dong

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(10), P. 4667 - 4677

Published: March 7, 2022

Constructing artificial dynamic architectures inside cells to rationally interfere with organelles is emerging as an efficient strategy regulate the behaviors and fate of cells, thus providing new routes for therapeutics. Herein, we develop intracellular K+-mediating assembly DNA tetrahedrons which realizes mitochondrial interference consequent regulation on energy metabolism living cells. In designer tetrahedron, one vertex was modified triphenylphosphine (TPP) targeting, other three vertexes were tethered guanine-rich sequences that could realize formation intermolecular G-quadruplexes, consequently led form aggregates in cytoplasm. The specially targeted mitochondria served a polyanionic barrier substance communication, generating significant inhibition effect aerobic respiration function associated glycolysis process, reduced production adenosine triphosphate (ATP). lack ATP impeded lamellipodium essential movement resulting inhibitory cell migration. Remarkably, migration capacity suppressed by high 50% cancer This work provides manipulation via endogenous molecule-mediating exogenous envisioned have great potential precise biomedicine.

Language: Английский

Citations

97
A Calcium Fluoride Nanozyme for Ultrasound‐Amplified and Ca2+‐Overload‐Enhanced Catalytic Tumor Nanotherapy DOI
Caihong Dong, Xinyue Dai, Xi Wang

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(43)

Published: Sept. 15, 2022

The anticancer mechanism of nanozymes is dominantly associated with the capacity for generation reactive oxygen species (ROS) caused by valence change metal elements. However, very little research focused on and has achieved exploration development enzyme-mimicking activities valence-invariable compounds. Herein, a distinct calcium fluoride (CaF2 ) nanozyme ultrasound (US)-enhanced peroxidase (POD)-mimicking activity rationally designed engineered efficient (Ca2+ )-overload-enhanced catalytic tumor nanotherapy, which first paradigm Ca-based cancer treatment. release exogenous Ca2+ ions from CaF2 nanocrystals deleterious ROS derived US-amplified POD-mimicking properties facilitate intracellular accumulation achieve -overload-induced mitochondrial dysfunction through introducing regulating calcium-pumping channels neoplastic cells. Especially, US as an energy input capable substantially amplifying nanozyme, ultimately achieving anti-neoplastic outcome both 4T1 breast H22 hepatic carcinoma animal models. Such discovery enzyme-like compounds can broaden cognition scope effectively serves field chemoreactive nanomedicine.

Language: Английский

Citations

81
Nanomaterials for photothermal cancer therapy DOI Creative Commons

Shufan Duan,

Yanling Hu, Ying Zhao

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(21), P. 14443 - 14460

Published: Jan. 1, 2023

This review summarizes the common inorganic and organic photothermal nanoagents their applications in tumor therapy. Additionally, challenges future prospects of nanomaterial-based therapy cancer treatment are discussed.

Language: Английский

Citations

77
Self-Adaptive Nanomaterials for Rational Drug Delivery in Cancer Therapy DOI

Guanqing Yang,

Yang Liu, Jinjin Chen

et al.

Accounts of Materials Research, Journal Year: 2022, Volume and Issue: 3(12), P. 1232 - 1247

Published: Nov. 28, 2022

ConspectusCancer is a disease characterized by uncontrolled growth and division of abnormal cells, which could be effectively suppressed various therapeutic agents in clinics. With the increasing knowledge cancer, rapid development different agents, such as small molecule cytotoxic drugs, nucleic acids, proteins/peptides, immunomodulators, so forth, has expanded modalities cancer therapy. However, their clinical application still hampered low tumor specificity when applied vivo. The irrational distribution healthy tissues may cause severe side effects reduce effect. Undoubtedly, achieving on-demand release at site critical for effective anticancer efficacies with reduced effects. Benefiting from nanotechnology, nanomaterials are widely exploited to significantly boost drugs tissue simultaneously decrease toxic on normal tissues, leading improved outcomes. Nevertheless, conventional have multiple drawbacks, poor targeting unavoidable leakage agents. In this regard, self-adaptive nanomaterials, respond signal changes emitted site, might realize spatiotemporally quantitatively specific drugs. Self-adaptive exhibited capabilities self-regulation self-feedback, whose properties, charge, size, shape, underwent an transformation response stimuli. Compared ones, successfully frequency drug doses within maintain concentrations cells more extended period, thus promoting rational application.This Account highlights recent developments field used delivery therapy, primarily based progress made our group. We discuss responding endogenous exogenous stimuli trigger targets cancer. Chemical approaches construction representative examples recently developed reviewed, multistimuli-responsive addressing shortcomings single stimulus-responsive also discussed. addition, we provide summary ongoing trials involving Finally, overview issues encountered during transition these materials research settings use. exploration optimization nanomaterial chemical design process. It hoped that insights provided will valuable reference creating next generation promising nanomaterials.

Language: Английский

Citations

74
An autocatalytic multicomponent DNAzyme nanomachine for tumor-specific photothermal therapy sensitization in pancreatic cancer DOI Creative Commons
Jiaqi Yan, Xiaodong Ma, Danna Liang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 30, 2023

Multicomponent deoxyribozymes (MNAzymes) have great potential in gene therapy, but their ability to recognize disease tissue and further achieve synergistic regulation has rarely been studied. Herein, Arginylglycylaspartic acid (RGD)-modified Distearyl acylphosphatidyl ethanolamine (DSPE)-polyethylene glycol (PEG) (DSPE-PEG-RGD) micelle is prepared with a DSPE hydrophobic core load the photothermal therapy (PTT) dye IR780 calcium efflux pump inhibitor curcumin. Then, MNAzyme distributed into hydrophilic PEG layer sealed phosphate through biomineralization. Moreover, RGD attached outer tail of for tumor targeting. The constructed nanomachine can release cofactor Ca2+ under acidic conditions self-assemble an active mode cleave heat shock protein (HSP) mRNA by consuming oncogene miRNA-21. Silencing miRNA-21 enhances expression suppressor PTEN, leading PTT sensitization. Meanwhile, curcumin maintains high intracellular suppress HSP-chaperone ATP disrupting mitochondrial homeostasis. Therefore, pancreatic cancer triple-sensitized IR780-mediated PTT. vitro vivo results show that MNAzyme-based strongly regulate HSP PTEN lead significant inhibition laser irradiation.

Language: Английский

Citations

73
Multifunctional Calcium–Manganese Nanomodulator Provides Antitumor Treatment and Improved Immunotherapy via Reprogramming of the Tumor Microenvironment DOI Creative Commons

Guanghong Luo,

Xing Li, Jihui Lin

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15449 - 15465

Published: Aug. 2, 2023

Ions play a vital role in regulating various biological processes, including metabolic and immune homeostasis, which involves tumorigenesis therapy. Thus, the perturbation of ion homeostasis can induce tumor cell death evoke responses, providing specific antitumor effects. However, strategies that exploit effects multiion are rare. We herein prepared pH-responsive nanomodulator by coloading curcumin (CU, Ca

Language: Английский

Citations

46
A pH-sensitive imidazole grafted polymeric micelles nanoplatform based on ROS amplification for ferroptosis-enhanced chemodynamic therapy DOI
Zhuangzhuang Zhang, Lingyang Wang, Zhaoyuan Guo

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 237, P. 113871 - 113871

Published: March 21, 2024

Language: Английский

Citations

37
Development of Aptamer-DNAzyme based metal-nucleic acid frameworks for gastric cancer therapy DOI Creative Commons
Jiaqi Yan, Rajendra Bhadane, Meixin Ran

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 1, 2024

The metal-nucleic acid nanocomposites, first termed frameworks (MNFs) in this work, show extraordinary potential as functional nanomaterials. However, thus far, realized MNFs face limitations including harsh synthesis conditions, instability, and non-targeting. Herein, we discover that longer oligonucleotides can enhance the efficiency stability of by increasing oligonucleotide folding entanglement probabilities during reaction. Besides, provide upgraded metal ions binding facilitating to load macromolecular protein drugs at room temperature. Furthermore, facilitate expansion nucleotide sequences, enabling disease-targeted MNFs. As a proof-of-concept, build an interferon regulatory factor-1(IRF-1) loaded Ca

Language: Английский

Citations

35
Nanomedomics DOI

Ganghao Liang,

Wanqing Cao, Dongsheng Tang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(17), P. 10979 - 11024

Published: April 18, 2024

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.

Language: Английский

Citations

31