Multifunctional Nano‐Biomaterials for Cancer Therapy via Inducing Enhanced Immunogenic Cell Death

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Jan. 26, 2023

Abstract Immunotherapy is considered to be one of the most promising methods overcome cancer. Immunogenic cell death (ICD), as a special form that can trigger an antitumor immune response, has attracted increasing attention for cancer immunotherapy. Presently, ICD‐mediating immunotherapy needs many hurdles including lack targeted delivery systems ICD inducers, insufficient immunity, and immunosuppressive tumor microenvironment. Recent research demonstrated nano‐biomaterials exhibit unique biochemphysical properties at nanoscale, providing prospective approach overcoming these obstacles. In this review, authors first survey occurrence, processes, detection ICD. Subsequently, recent advances applied enhance according key steps in process ICD, particularly with focus on mechanisms lifting schemes are investigated. Finally, based achievement representative studies, prospects challenges nanotechnology therapy discussed enable clinical translation.

Language: Английский

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Dual-stimulus phototherapeutic nanogel for triggering pyroptosis to promote cancer immunotherapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 358, P. 219 - 231

Published: May 4, 2023

Language: Английский

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Magnetic Resonance Imaging Nanoprobe Quantifies Nitric Oxide for Evaluating M1/M2 Macrophage Polarization and Prognosis of Cancer Treatments

ACS Nano, Journal Year: 2023, Volume and Issue: 17(24), P. 24854 - 24866

Published: Dec. 4, 2023

Macrophages play a crucial role in immune activation and provide great value the prognosis of cancer treatments. Current strategies for prognostic evaluation macrophages mainly target specific biomarkers to reveal number distribution tumors, whereas phenotypic change M1 M2 situ is less understood. Here, we designed an ultrasmall superparamagnetic iron oxide nanoparticle-based molecular imaging nanoprobe quantify repolarization by magnetic resonance (MRI) using redox-active nitric (NO) as vivid chemical target. The equipped with O-phenylenediamine groups could react intracellular NO molecules during phenotype, leading electrical attraction colloidal aggregation nanoprobes. Consequently, prominent changes T1 T2 relaxation MRI allow quantification macrophage polarization. In 4T1 breast model, was able polarization predict treatment efficiency both immunotherapy radiotherapy paradigms. This study presents noninvasive approach monitor providing insight into treatments regarding macrophage-mediated responses.

Language: Английский

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Rationally designed NIR-II excitable and endoplasmic reticulum-targeted molecular phototheranostics for imaging-guided enhanced photoimmunotherapy of triple-negative breast cancer

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 22, 2025

Triple-negative breast cancer (TNBC) is a highly aggressive subtype of characterized by an extremely poor prognosis. Photoimmunotherapy has emerged as promising strategy for the treatment TNBC. This approach works selectively destroying tumor cells, releasing tumor-associated antigens, activating immune system, and effectively inhibiting proliferation metastasis. However, majority current phototheranostic approaches are hindered limited tissue penetration in first near-infrared (NIR-I) ultraviolet–visible (UV–Vis) regions. Additionally, due to lack specific subcellular targets, it may be difficult treat deep-seated lesions with ambiguous extensive boundaries caused TNBC metastases. Consequently, development effective, deep-penetrating, organelle-targeted phototheranostics essential enhancing outcomes work proposes novel molecular design NIR-II realize planar rigid conjugation alkyl chain functionalization. The di-hexaalkyl chains vertical configuration on donor (4H-cyclopenta[2,1-b:3,4-b'] dithiophene) shielding units (fluorene) introduced construct S-D-A-D-S type (IR-FCD). structure IR-FCD exhibits robust intramolecular charge transfer capability, lower band gap, enhanced photon absorption properties, significant steric hindrance from vertically arranged minimize non-radiative energy loss. By incorporating N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide at terminus elongated chain, followed self-assembly into DSPE-S-S-PEG2000, excitable (IR-FCD-Ts NPs) endoplasmic reticulum (ER) targeting capability were successfully synthesized imaging-guided photoimmunotherapy IR-FCD-Ts NPs demonstrate exceptional optical characteristics, maximum 1068 nm (extending 1300 nm) emission 1273 1700 nm), along high molar coefficient 2.76*104 L/mol·c 1064 aqueous solution. Under exposure laser irradiation, exhibit superior photothermal properties have potential photodynamic therapy. ER, thereby inducing ER stress significantly immunogenic cell death (ICD) triggers strong antitumor response inhibits metastasis

Language: Английский

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Advanced Nanosystems for Cancer Therapeutics: A Review

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(9), P. 7123 - 7149

Published: April 25, 2023

Since cancer has a very complex pathophysiology, existing treatment strategies encounter several challenges such as the lack of specificity/selectivity, induction multidrug resistance, and possible side effects/toxicity. A wide variety organic, inorganic, hybrid nanosystems have been designed with unique magnetic, thermal, mechanical, electrical, optical properties for targeted therapy. These advanced enhanced bioavailability, biocompatibility, drug loading capacity developed therapy to reduce toxicity improve targeting properties. In this context, persist their clinical translational studies enhancement therapeutic efficiency well optimization synthesis conditions large-scale production. addition, despite promising preclinical results, number available patients is still low, partly due understanding differences among animal model species humans that influence behavior functionality these nanosystems. Regarding this, organ-on-a-chip platforms can significantly help in screening delivery aspects cancer/tumor cells modeling research; organs-on-chip approach also be helpful analyze cancer–immune interactions. Future should focus on exploration multifunctional synergistic chemo-photothermal, photothermal/photodynamic, immunotherapeutic potentials smart theranostic capabilities. Herein, recent advancements pertaining applications therapeutics are deliberated. Current obstacles limitations hindering application from research uses discussed while providing recommendations more efficient adoption nanomaterials cancers.

Language: Английский

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Oxygen‐Deficient Bioceramics: Combination of Diagnosis, Therapy, and Regeneration

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(41)

Published: June 1, 2023

The journey of ceramics in medicine has been synchronized with an evolution from the first generation-alumina, zirconia, etc.-to third -3D scaffolds. There is up-and-coming member called oxygen-deficient or colored bioceramics, which have recently found their way through biomedical applications. oxygen vacancy steers light absorption toward visible and near infrared regions, making bioceramics multifunctional-therapeutic, diagnostic, regenerative. Oxygen-deficient are capable turning into heat reactive species for photothermal photodynamic therapies, respectively, concomitantly yield photoacoustic images. Different types developed various synthesis routes. Some them like TiO2-x , MoO3-x WOx more investigated applications, whereas rest yet to be scrutinized. most prominent advantage these over other biomaterials multifunctionality endowed a change microstructure. some challenges ahead this category discussed at end present review. By shedding on born subcategory, it believed that field will undergo big step further as platforms naturally multifunctional.

Language: Английский

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Advances in CAR‐Engineered Immune Cell Generation: Engineering Approaches and Sourcing Strategies

Advanced Science, Journal Year: 2023, Volume and Issue: 10(35)

Published: Oct. 31, 2023

Abstract Chimeric antigen receptor T‐cell (CAR‐T) therapy has emerged as a highly efficacious treatment modality for refractory and relapsed hematopoietic malignancies in recent years. Furthermore, CAR technologies cancer immunotherapy have expanded from CAR‐T to CAR‐natural killer cell (CAR‐NK), CAR‐cytokine‐induced (CAR‐CIK), CAR‐macrophage (CAR‐MΦ) therapy. Nevertheless, the high cost complex manufacturing processes of ex vivo generation autologous products hampered broader application. There is an urgent need develop efficient economical paradigm shift exploring new sourcing strategies engineering approaches toward generating CAR‐engineered immune cells benefit patients. Currently, researchers are actively investigating various optimize preparation these potent immunotherapeutic agents. In this work, latest research progress summarized. Perspectives on future provided, approaches, diverse sources used their development focused upon.

Language: Английский

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Ultrasound Imaging of Tumor Vascular CD93 with MMRN2 Modified Microbubbles for Immune Microenvironment Prediction

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Jan. 25, 2024

Vascular microenvironment is found to be closely related immunotherapy efficacy. Identification and ultrasound imaging of the unique vascular characteristics, able predict immune microenvironment, important for decision-making. Herein, it proved that high CD93 expression in tumor vessels poor response prostate cancer. For molecular CD93, CD93-targeted microbubbles (MBs) consist a gaseous core MMRN2 (Multimerin-2) containing cell membrane (CM) /lipid hybrid then synthesized. In vitro vivo assays demonstrate these MBs can recognize efficiently accumulate within regions highly expressing CD93. Contrast-enhanced (CEUS) with demonstrates targeted intensity negatively inflammatory (TIME) cytotoxic T infiltration. Together, endothelial predictor immunosuppressive have great potential evaluate status.

Language: Английский

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Dual‐Functional Nanodroplet for Tumor Vasculature Ultrasound Imaging and Tumor Immunosuppressive Microenvironment Remodeling

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Abstract Accurately evaluating tumor neoangiogenesis and conducting precise interventions toward an immune‐favorable microenvironment are of significant clinical importance. In this study, a novel nanodroplet termed as the nanodroplet‐based ultrasound contrast agent therapeutic (NDs UCA/Tx ) is designed for imaging neoangiogenesis. Briefly, NDs shell constructed from engineered CMs containing antigen, vascular endothelial growth factor receptor 1 (VEGFR1) extracellular domain 2–3, CD93 ligand multimerin 2. The core composed perfluorohexane immune adjuvant R848. After injection, found to be enriched in vasculature with high expression CD93. When triggered by ultrasound, underwent acoustic droplet vaporization generated enhanced signal. Some microbubbles exploded resultant debris (with antigen R848) together adsorbed VEGF taken up nearby cells. This cleared local normalization, also served vaccine activate response. Using syngeneic mouse model, satisfactory performance activation confirmed. Thus, multifunctional successfully developed molecular remodeling microenvironment.

Language: Английский

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Nanobiotechnology boosts ferroptosis: opportunities and challenges

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 8, 2024

Ferroptosis, distinct from apoptosis, necrosis, and autophagy, is a unique type of cell death driven by iron-dependent phospholipid peroxidation. Since ferroptosis was defined in 2012, it has received widespread attention researchers worldwide. From biochemical perspective, the regulation strongly associated with cellular metabolism, primarily including iron lipid redox metabolism. The distinctive regulatory mechanism holds great potential for overcoming drug resistance-a major challenge treating cancer. considerable role nanobiotechnology disease treatment been widely reported, but further more systematic discussion on how enhances therapeutic efficacy ferroptosis-associated diseases still needs to be improved. Moreover, while exciting cancer relatively well summarized, its applications other diseases, such as neurodegenerative cardiovascular cerebrovascular kidney disease, remain underreported. Consequently, necessary fill these gaps complete ferroptosis. In this review, we provide an extensive introduction background elaborate network. Subsequently, discuss various advantages combining enhance reduce side effects diseases. Finally, analyze feasibility improving clinical outcomes based needs, current limitations future directions ferroptosis, which will not only significant guidance also accelerate their translations.

Language: Английский

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