Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

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Nanoscale Metal–Organic Framework with an X-ray Triggerable Prodrug for Synergistic Radiotherapy and Chemotherapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(34), P. 18698 - 18704

Published: Aug. 15, 2023

As heavy-metal-based nanoscale metal–organic frameworks (nMOFs) are excellent radiosensitizers for radiotherapy via enhanced energy deposition and reactive oxygen species (ROS) generation, we hypothesize that nMOFs with covalently conjugated X-ray triggerable prodrugs can harness the ROS on-demand release of chemotherapeutics chemoradiotherapy. Herein, report design a novel nMOF, Hf-TP-SN, an X-ray-triggerable 7-ethyl-10-hydroxycamptothecin (SN38) prodrug synergistic chemotherapy. Upon irradiation, electron-dense Hf12 secondary building units serve as to enhance hydroxyl radical generation triggered SN38 hydroxylation 3,5-dimethoxylbenzyl carbonate followed by 1,4-elimination, leading 5-fold higher from Hf-TP-SN than its molecular counterpart. result, plus radiation induces significant cytotoxicity cancer cells efficiently inhibits tumor growth in colon breast mouse models.

Language: Английский

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Nanomedicine Remodels Tumor Microenvironment for Solid Tumor Immunotherapy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(15), P. 10217 - 10233

Published: April 2, 2024

Although immunotherapy is relatively effective in treating hematological malignancies, their efficacy against solid tumors still suboptimal or even noneffective presently. Compared to cancers, exhibit strikingly different immunosuppressive microenvironment, severely deteriorating the of immunotherapy: (1) chemical features such as hypoxia and mild acidity suppress activity immune cells, (2) pro-tumorigenic domestication cells microenvironment within further undermines effectiveness immunotherapy, (3) dense physical barrier tumor tissues prevents intratumoral infiltration contact killing active cells. Therefore, we believe that reversing are critical priority for tumors. Due unique morphologies, structures, compositions, nanomedicines have become powerful tools achieving this goal. In Perspective, will first briefly introduce then summarize most recent progresses nanomedicine-based by remodeling immune-microenvironment a comprehensive manner. It highly expected Perspective aid advancing tumors, optimistic on future development burgeoning field.

Language: Английский

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An Immunocompetent Hafnium Oxide-Based STING Nanoagonist for Cancer Radio-immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 4189 - 4204

Published: Jan. 9, 2024

cGAS-STING signaling plays a critical role in radiotherapy (RT)-mediated immunomodulation. However, RT alone is insufficient to sustain STING activation tumors under safe X-ray dose. Here, we propose radiosensitization cooperated with cGAS stimulation strategy by engineering core–shell structured nanosized radiosensitizer-based agonist, which constituted the hafnium oxide (HfO2) core and manganese (MnO2) shell. HfO2-mediated enhances immunogenic cell death afford tumor associated antigens adequate cytosolic dsDNA, while GSH-degradable MnO2 sustainably releases Mn2+ improve recognition sensitization of cGAS. The synchronization sustained supply cumulative dsDNA damage synergistically augments irradiated tumors, thereby enhancing RT-triggered local system effects when combined an immune checkpoint inhibitor. Therefore, synchronous demonstrated as potent immunostimulation optimize cancer radio-immuotherapy.

Language: Английский

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Advances and applications of nanoparticles in cancer therapy

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

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Radiotherapy and immunology

The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 221(7)

Published: May 21, 2024

The majority of cancer patients receive radiotherapy during the course treatment, delivered with curative intent for local tumor control or as part a multimodality regimen aimed at eliminating distant metastasis. A major focus research has been DNA damage; however, in past two decades, emphasis shifted to important role immune system plays radiotherapy-induced anti-tumor effects. Radiotherapy reprograms microenvironment, triggering and RNA sensing cascades that activate innate immunity ultimately enhance adaptive immunity. In opposition, also induces suppression immunity, including recruitment regulatory T cells, myeloid-derived suppressor suppressive macrophages. balance pro- is regulated by chemokines cytokines. Microbiota can influence outcomes under clinical investigation. Blockade PD-1/PD-L1 axis CTLA-4 extensively investigated combination radiotherapy; we include review trials involving inhibition these checkpoints radiotherapy.

Language: Английский

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Biointerface‐Engineered Hybrid Nanovesicles for Targeted Reprogramming of Tumor Microenvironment

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: June 9, 2024

Abstract The tumor microenvironment (TME) of typical types such as triple‐negative breast cancer is featured by hypoxia and immunosuppression with abundant tumor‐associated macrophages (TAMs), which also emerge potential therapeutic targets for antitumor therapy. M1‐like macrophage‐derived exosomes (M1‐Exos) have emerged a promising candidate their tumor‐targeting macrophage‐polarization capabilities. However, the limited drug‐loading efficiency stability M1‐Exos hindered effectiveness in applications. Here, hybrid nanovesicle developed integrating AS1411 aptamer‐conjugated liposomes (AApt‐Lips), termed M1E/AALs. obtained M1E/AALs are loaded perfluorotributylamine (PFTBA) IR780, P‐I, to construct P‐I@M1E/AALs reprogramming TME alleviating engineering TAMs. P‐I@M1E/AAL‐mediated therapy enhances situ generation reactive oxygen species, repolarizes TAMs toward an phenotype, promotes infiltration T lymphocytes. synergistic based on significantly suppresses growth prolongs survival 4T1‐tumor‐bearing mice. By multiple treatment modalities, P‐I@M1E/AAL nanoplatform demonstrates approach overcoming hypoxic immunosuppressive targeted TAM enhanced photodynamic immunotherapy. This study highlights innovative TAM‐engineering platform tumors characterized TME.

Language: Английский

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Sono‐Triggered Cascade Lactate Depletion by Semiconducting Polymer Nanoreactors for Cuproptosis‐Immunotherapy of Pancreatic Cancer

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(30)

Published: May 6, 2024

Abstract The high level of lactate in tumor microenvironment not only promotes development and metastasis, but also induces immune escape, which often leads to failures various therapy strategies. We here report a sono‐triggered cascade depletion strategy by using semiconducting polymer nanoreactors (SPN LCu ) for cancer cuproptosis‐immunotherapy. SPN mainly contain as sonosensitizer, oxidase (LOx) conjugated via reactive oxygen species (ROS)‐cleavable linker chelated Cu 2+ . Upon ultrasound (US) irradiation, the generates singlet ( 1 O 2 cut ROS‐cleavable allow release LOx that catalyzes produce hydrogen peroxide (H ). will be reduced + microenvironment, reacts with produced H obtain hydroxyl radical (⋅OH) further improves destroying linkers. As such, achieves effective depletion, thus relieving immunosuppressive roles lactate. Moreover, toxic cuproptosis cause immunogenic cell death (ICD) activating antitumor immunological effect. are used treat both subcutaneous deep‐tissue orthotopic pancreatic observably enhanced efficacy restricting growths. This study provides precise tactic therapy.

Language: Английский

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An Engineered Nanoplatform with Tropism Toward Irradiated Glioblastoma Augments Its Radioimmunotherapy Efficacy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: May 7, 2024

Combining radiotherapy with immune checkpoint blockade therapy offers a promising approach to treat glioblastoma multiforme (GBM), yet challenges such as limited effectiveness and immune-related adverse events (irAEs) persist. These issues are largely due the failure in targeting immunomodulators directly tumor microenvironment. To address this, biomimetic nanoplatform that combines genetically modified mesenchymal stem cell (MSC) membrane bioactive nanoparticle core for chemokine-directed radioimmunotherapy of GBM is developed. The CC chemokine receptor 2 (CCR2)-overexpressing MSC acts tactical tentacle achieve radiation-induced tropism toward abundant (CC motif) ligand (CCL2) irradiated gliomas. core, comprising diselenide-bridged mesoporous silica nanoparticles (MSNs) PD-L1 antibodies (αPD-L1), enables X-ray-responsive drug release radiosensitization. In two murine models orthotopic tumors, this reinvigorated immunogenic death, augmented efficacy specificity radioimmunotherapy, reduced occurrence irAEs. This study suggests strategy targeted delivery, presents potent enhances safety radio-immunotherapy.

Language: Английский

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