Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
Abstract
Pyroptosis
is
gaining
attention
for
its
ability
to
activate
the
immune
system.
However,
controlling
induction
of
specific
pyroptotic
tumor
cell
death
effectively
response
a
challenge.
In
this
study,
novel
“bacterial
bomb”
platform
developed
and
designed
precisely
regulate
pyroptosis
using
light
as
trigger,
thereby
optimizing
responses.
The
employs
Escherichia
coli
(Ec)
carrier
introduce
gasdermin
D
(GSDMD)
plasmid
(pGSDMD)
into
Ec
adsorb
photosensitizer
indocyanine
green
(ICG)
on
surface,
termed
Ec‐pGSDMD‐ICG.
ICG
has
photothermal
effects
(PTE)
photodynamic
(PDE).
Under
808
nm
laser
irradiation,
generates
thermal
singlet
oxygen
(
1
O
2
),
leading
rupture
release
pGSDMD,
which
expresses
sufficient
GSDMD
in
cells.
Furthermore,
lipopolysaccharides
(LPS)
caspase
pathways
(caspase‐1
caspase‐11),
cleave
produce
GSDMD‐N,
inducing
Light
triggered
Ec‐pGSDMD‐ICG
not
only
efficiently
induces
cells
with
low
content,
but
also
enhances
moderate
all
while
activating
system
effective
treatment.
This
approach
opens
new
strategies
research
directions
mediated
immunotherapy.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(12), P. 9031 - 9042
Published: March 12, 2024
Cuproptosis
has
drawn
enormous
attention
in
antitumor
material
fields;
however,
the
responsive
activation
of
cuproptosis
against
tumors
using
nanomaterials
with
high
atom
utilization
is
still
challenging.
Herein,
a
copper-based
nanoplatform
consisting
acid-degradable
copper
hydride
(CuH)
nanoparticles
was
developed
via
microfluidic
synthesis.
After
coating
tumor-targeting
hyaluronic
acid
(HA),
denoted
as
HA-CuH-PVP
(HCP)
shows
conspicuous
damage
toward
tumor
cells
by
generating
Cu+
and
hydrogen
(H2)
simultaneously.
can
induce
apoptosis
relying
on
Fenton-like
reactions
lead
to
causing
mitochondrial
protein
aggregation.
Besides,
existence
H2
enhance
both
cell
death
types
dysfunction
intracellular
redox
homeostatic
disorders.
In
vivo
experimental
results
further
exhibit
desirable
potential
HCP
for
killing
inhibiting
lung
metastases,
which
will
broaden
horizons
designing
materials
triggering
better
efficacy.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(29)
Published: Feb. 23, 2024
Abstract
Autophagy,
a
lysosome‐involved
degradation
pathway,
as
self‐protective
cellular
process,
always
weakens
the
efficiency
of
tumor
therapies.
Herein,
for
first
time,
biodegradable
copper
(Cu)
ions
doped
layered
double
hydroxide
(Cu‐LDH)
nanoparticles
are
reported
cancer
immunotherapy
via
lysosomal
rupture‐mediated
“Broken
Window
Effect”.
Only
injection
Cu‐LDH
single
therapeutic
agent
achieves
various
organelles
destruction
after
rupture,
well
abnormal
aggregation
Cu
in
cells
cuproptosis
and
pyroptosis.
More
importantly,
autophagy
inhibition
caused
by
rupture
improves
overload‐mediated
pyroptosis
blocking
lysosome‐mediated
bulk
leading
to
good
anti‐tumor
immune
responses
ultimately
high‐efficiency
growth
inhibition.
This
Effect”
provides
new
paradigm
enhanced
therapy.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 5, 2025
Copper-based
nanoparticles
have
garnered
significant
interest
in
cancer
therapy
due
to
their
ability
induce
oxidative
stress
and
cuproptosis
cells.
However,
antitumor
effectiveness
is
constrained
by
the
dynamic
redox
balance
metabolic
shift
between
phosphorylation
glycolysis.
Here,
a
polydopamine-coated
copper-α-ketoglutaric
acid
(α-KG)
coordination
polymer
nanoparticle
(CKPP)
designed
for
combined
pyroptosis-cuproptosis
immunotherapy
amplifying
reactive
oxygen
species
(ROS)
production
regulating
cellular
metabolism.
The
intracellular
imbalance
achieved
through
synergistic
effects
of
α-KG-induced
mitochondrial
reprogramming,
photothermally
enhanced
superoxide
dismutase-like
activity
polydopamine,
glutathione
depletion
copper
ions.
multifaceted
modulation
results
substantial
increase
ROS
levels,
triggering
subsequent
pyroptosis
Furthermore,
α-KG
shifts
metabolism
from
glycolysis
phosphorylation,
thereby
enhancing
induced
combination
dyshomeostasis
inhibition
potent
enhancement
pyroptosis-cuproptosis-mediated
therapy.
In
murine
model
colorectal
cancer,
CKPP
exhibited
remarkable
anticancer
effect,
achieving
tumor
rate
96.3%
complete
eradication
two
out
five
cases.
Overall,
this
bio-engineered
metal-organic
nanocomposite
demonstrates
potential
treating
immunotherapy.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(7)
Published: Dec. 8, 2023
Abstract
Endogenous
essential
metal
ions
play
an
important
role
in
many
life
processes,
especially
tumor
development
and
immune
response.
The
approval
of
various
metallodrugs
for
therapy
brings
more
attention
to
the
antitumor
effect
ions.
With
deepening
understanding
regulation
mechanisms
ion
homeostasis
vivo,
breaking
intracellular
becomes
a
new
means
inhibit
proliferation
cells
activate
Diverse
nanomedicines
with
loading
small
molecular
regulators
or
have
been
developed
disrupt
cells,
higher
safety
efficiency
than
free
compounds.
This
comprehensive
review
focuses
on
latest
progress
regulation‐based
including
calcium
(Ca
2+
),
ferrous
(Fe
cuprous
(Cu
+
managanese
(Mn
zinc
(Zn
).
physiological
functions
processes
are
summarized
guide
design
nanomedicines.
Then
ions‐based
some
efficient
synergistic
therapies
highlighted.
Finally,
challenges
future
developments
also
discussed,
hoping
provide
reference
finding
effective
therapies.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(14)
Published: Dec. 28, 2023
Pyroptosis
has
garnered
increasing
attention
in
cancer
immunotherapy.
Moreover,
plasma
membrane
damage
by
reactive
oxygen
species
(ROS)
is
considered
an
effective
strategy
for
promoting
pyroptosis.
However,
the
current
tactics
enhancing
rupture
pyroptosis
are
limited
inherent
drawbacks
of
ROS
and
immunosuppressive
tumor
microenvironment.
Herein,
a
self-adaptive
inducer
(LPZ)
designed
integrating
Lactobacillus
rhamnosus
GG
(LGG)
enzyme-like
metal-organic
framework
to
achieve
potent
LPZ
can
adhere
cell
membranes
through
interaction
between
pili
LGG
mucin
cells.
In
particular,
adaptive
formula
gradually
enhance
ability
nanozymes
produce
creating
acidic
microenvironment
anaerobic
respiration.
These
results
verify
that
could
generate
high
levels
both
on
within
cells,
leading
pyroptotic
death
strong
antitumor
immunity.
Meanwhile,
eventually
killed
this
process
halt
their
respiration
prevent
potential
biosafety
concerns.
Overall,
work
provides
new
inspiration
design
nanocatalytic
drugs
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 18, 2024
Abstract
Two-dimensional
nanomaterials
(2D
NMs),
characterized
by
a
large
number
of
atoms
or
molecules
arranged
in
one
dimension
(typically
thickness)
while
having
tiny
dimensions
the
other
two
dimensions,
have
emerged
as
pivotal
class
materials
with
unique
properties.
Their
flat
and
sheet-like
structure
imparts
distinctive
physical,
chemical,
electronic
attributes,
which
offers
several
advantages
biomedical
applications,
including
enhanced
surface
area
for
efficient
drug
loading,
surface-exposed
allowing
precise
chemical
modifications,
ability
to
form
hierarchical
multilayer
structures
synergistic
functionality.
Exploring
their
nano-bio
interfacial
interactions
biological
components
holds
significant
importance
comprehensively
systematically
guiding
safe
applications.
However,
current
lack
in-depth
analysis
comprehensive
understanding
effects
on
cancer
treatment
motivates
our
ongoing
efforts
this
field.
This
study
provides
survey
recent
advances
utilizing
2D
NMs
treatment.
It
insights
into
structural
characteristics,
synthesis
methods,
modifications
diverse
NMs.
The
investigation
further
delves
formation
interfaces
during
vivo
utilization.
Notably,
discusses
wide
array
applications
With
potential
revolutionize
therapeutic
strategies
outcomes,
are
poised
at
forefront
treatment,
holding
promise
transformative
advancements.
Graphical
