Oral
diseases
such
as
gingivitis
and
periodontitis
represent
signi
cant
global
health
challenges,
a
ecting
substantial
portion
of
the
population.These
conditions,
driven
by
bacterial
bio
lms,
can
cause
severe
damage
to
tooth-supporting
tissues,
leading
tooth
loss
impacting
overall
well-being.Traditional
oral
antibiotics
face
limitations,
including
broad-spectrum
side
e
ects
insu
cient
concentration
at
infection
sites,
often
resulting
in
antimicrobial
resistance.This
mini-review
explores
potential
nanobots
for
targeted
drug
delivery
treating
infections.Nanobots,
ranging
from
1
100
nanometers,
navigate
cavity,
directly
targeting
lms
releasing
agents
controlled
manner.This
approach
enhances
reduces
systemic
ects,
minimizes
resistance
development.Various
types
nanobots,
dentifrobots
pharmacytes,
are
discussed
their
roles
healthcare.Recent
advancements
demonstrate
cacy
vitro
vivo,
highlighting
ability
eradicate
deliver
drugs
precisely.However,
challenges
biocompatibility,
stability,
regulatory
hurdles
must
be
addressed
clinical
application.Future
directions
include
integrating
multifunctional
capabilities
simultaneous
treatment
tissue
repair,
real-time
monitoring
through
advanced
imaging
biosensing,
personalized
therapies
tailored
individual
microbiomes.By
overcoming
these
have
revolutionize
healthcare,
o
ering
innovative
solutions
ectively
manage
treat
infections,
ultimately
improving
patient
outcomes
health.
Materials,
Journal Year:
2024,
Volume and Issue:
17(2), P. 456 - 456
Published: Jan. 18, 2024
Biomaterials
embody
a
groundbreaking
paradigm
shift
in
the
field
of
drug
delivery
and
human
applications.
Their
versatility
adaptability
have
not
only
enriched
therapeutic
outcomes
but
also
significantly
reduced
burden
adverse
effects.
This
work
serves
as
comprehensive
overview
biomaterials,
with
particular
emphasis
on
their
pivotal
role
delivery,
classifying
them
terms
biobased,
biodegradable,
biocompatible
nature,
highlighting
characteristics
advantages.
The
examination
delves
into
extensive
array
applications
for
biomaterials
encompassing
diverse
medical
fields
such
cancer
therapy,
cardiovascular
diseases,
neurological
disorders,
vaccination.
explores
actual
challenges
within
this
domain,
including
potential
toxicity
complexity
manufacturing
processes.
These
emphasize
necessity
thorough
research
continuous
development
regulatory
frameworks.
second
aim
review
is
to
navigate
through
compelling
terrain
recent
advances
prospects
envisioning
healthcare
landscape
where
they
empower
precise,
targeted,
personalized
delivery.
transform
staggering,
promise
treatments
tailored
individual
patient
needs,
offering
hope
improved
efficacy,
fewer
side
effects,
brighter
future
practice.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(21)
Published: Jan. 30, 2024
Abstract
Rescuing
dental
implants
from
plaque‐induced
infection
and
implementing
effective
plaque
control
methods
in
a
limited
oral
environment
pose
challenges
for
modern
dentistry.
To
address
this
issue,
Al
ion
doped
strontium
titanate/titanium
dioxide
nanotubes
(Al‐SrTiO
3
/TiO
2
nanotubes,
Al‐STNT)
are
designed
as
an
ultrasound‐responsive
nanocoating
immobilized
on
the
Ti
implant
surface.
Introducing
3+
ions
into
inorganic
sonosensitive
SrTiO
heterojunction
induces
oxygen
vacancies
disrupts
lattice
of
.
By
overcoming
bandgap
barrier
through
ultrasonic
stimulated
piezoelectric
effect,
Al‐STNT
produces
more
reactive
species
(ROS).
In
sonodynamic
therapy
(SDT)
process,
stimulus
abundant
ROS
efficiently
disrupting
bacteria
biofilm
inhibiting
metabolism.
Moreover,
specific
nanoscale
coating
endows
with
osteogenic
activity,
facilitating
formation
rigid
osseointegration
between
surface
alveolar
bone.
mimicking
human
rats,
demonstrates
optimal
postimplant
while
retaining
its
antibacterial
ability
sonosensitizer.
Thanks
to
portability
ultrasound
instrument
stability
implant‐based
sonosensitizer,
strategy
presents
attractive
option
patients
self‐treat
secure
long‐term
success
their
implants.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(11), P. 13353 - 13383
Published: March 11, 2024
Biofilm
contamination
presents
a
significant
threat
to
public
health,
the
food
industry,
and
aquatic/marine-related
applications.
In
recent
decades,
although
various
methods
have
emerged
combat
biofilm
contamination,
intricate
persistent
nature
of
biofilms
makes
complete
eradication
challenging.
Therefore,
innovative
alternative
solutions
are
imperative
for
addressing
formation.
Instead
solely
focusing
on
mature
biofilms,
strategically
advantageous
measures
involve
delay
or
prevention
formation
surfaces.
Quorum
sensing,
communication
system
enabling
bacteria
coordinate
their
behavior
based
population
density,
plays
pivotal
role
in
numerous
microbial
species.
Materials
possessing
antibiofilm
properties
that
target
quorum
sensing
gained
considerable
attention
potential
prevent
This
Review
consolidates
research
progress
utilization
materials
with
antiquorum
combating
These
can
be
categorized
into
three
distinct
types:
(i)
nanomaterials,
(ii)
surfaces,
(iii)
hydrogels
capabilities.
Finally,
concludes
brief
discussion
current
challenges
outlines
avenues
future
research.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
23, P. 100827 - 100827
Published: Oct. 2, 2023
Biofilms
are
aggregates
of
organized
microbial
growth
that
function
as
barriers
and
create
a
stable
internal
environment
for
cell
survival.
The
bacteria
in
the
biofilms
exhibit
characteristics
quite
different
from
planktonic
bacteria,
such
strong
resistance
to
antibiotics
other
bactericides,
getting
out
host
immunity,
developing
harsh
environments,
which
all
contribute
persistent
intractable
treatment.
Hence,
there
is
an
urgent
need
develop
novel
materials
strategies
combat
biofilms.
However,
most
reviews
on
anti-biofilms
published
recent
years
based
specific
fields
or
materials.
Microorganisms
ubiquitous,
except
context
medical
health
issues;
however,
exert
detrimental
effects
advancement
progress
various
fields.
Therefore,
this
review
aims
provide
comprehensive
summary
effective
methodologies
applicable
across
industries.
Firstly,
process
formation
was
introduced
enhance
our
comprehension
"enemy".
Secondly,
intervene
important
links
were
discussed,
taking
timely
action
during
early
weak
stages
Thirdly,
treatment
mature
summarized
deal
with
break
through
defense
line.
Finally,
several
substances
antibacterial
properties
presented.
concludes
standpoint
author
about
potential
developments
strategies.
This
may
help
researchers
quickly
understand
research
challenges
field
design
more
efficient
methods
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 8, 2024
Intraoral
wounds
represent
a
particularly
challenging
category
of
mucosal
and
hard
tissue
injuries,
characterized
by
the
unique
structures,
complex
environment,
distinctive
healing
processes
within
oral
cavity.
They
have
common
occurrence
yet
frequently
inflict
significant
inconvenience
pain
on
patients,
causing
serious
decline
in
quality
life.
A
variety
novel
functional
dressings
specifically
designed
for
moist
dynamic
environment
been
developed
realized
accelerated
improved
wound
healing.
Thoroughly
analyzing
summarizing
these
materials
is
paramount
importance
enhancing
understanding
proficiently
managing
intraoral
wounds.
In
this
review,
particular
characteristics
are
firstly
described.
Up-to-date
knowledge
various
forms,
properties,
applications
existing
products
then
intensively
discussed,
which
categorized
into
animal
products,
plant
extracts,
natural
polymers,
synthetic
products.
To
conclude,
review
presents
comprehensive
framework
currently
available
dressings,
with
an
aim
to
provoke
inspiration
future
studies
design
more
convenient
versatile
materials.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
41, P. 271 - 292
Published: July 24, 2024
Periodontitis
is
an
inflammatory
disease
caused
by
bacterial
biofilms,
which
leads
to
the
destruction
of
periodontal
tissue.
Current
treatments,
such
as
mechanical
cleaning
and
antibiotics,
struggle
effectively
address
persistent
inflammation,
tissue
damage.
A
new
approach
involves
developing
a
Janus
nanomotor
(J-CeM@Au)
coating
cerium
dioxide-doped
mesoporous
silica
(CeM)
with
gold
nanoparticles
(AuNPs).
This
exhibits
thermophoretic
motion
when
exposed
near-infrared
(NIR)
laser
light
due
temperature
gradient
produced
photothermal
effects
asymmetrically
distributed
AuNPs.
The
NIR
provides
energy
for
propulsion
activates
nanomotor's
antibacterial
properties,
allowing
it
penetrate
biofilms
kill
bacteria.
Additionally,
ability
scavenge
reactive
oxygen
species
(ROS)
can
modulate
immune
response
create
regenerative
environment,
promoting
healing
Overall,
this
multifunctional
offers
promising
treating
periodontitis
simultaneously
addressing
biofilm
management
modulation
autonomous
movement.
Aggregate,
Journal Year:
2024,
Volume and Issue:
5(5)
Published: April 30, 2024
Abstract
Dental
caries
is
one
of
the
most
prevalent
and
costly
biofilm‐induced
oral
diseases
that
causes
deterioration
mineralized
tooth
tissue.
Traditional
antimicrobial
agents
like
antibiotics
peptides
(AMPs)
struggle
to
effectively
eradicate
bacteria
in
biofilms
without
eliciting
resistance.
Herein,
we
demonstrate
construction
FeOOH@Fe‐Lysine@Au
nanostructured
AMPs
(nAMPs)
distinguished
by
their
AMP‐like
antibacterial
activity
self‐producing
reactive
oxygen
species
(ROS)
capacity
for
treatment.
On
hand,
nAMPs
can
catalyze
glucose
oxidation
generate
ROS
within
cariogenic
biofilm
microenvironment,
resulting
disintegration
extracellular
polymeric
substance
matrix
exposure
bacteria.
other
attach
bacterial
surfaces
via
electrostatic
attractions,
proceeding
damage
membranes,
disrupt
metabolic
pathways,
inhibit
protein
synthesis
through
aggregated
lysine
generated
ROS.
Based
on
this
mechanism,
Streptococcus
mutans
its
associated
biofilm,
significantly
impeding
progression
dental
caries.
Given
straightforward
cost‐efficient
preparation
compared
require
specific
sequences,
minimal
adverse
impacts
gingival/palatal
tissues,
major
organs,
oral/gut
microbiomes,
our
research
may
promote
development
novel
therapeutic
health
maintenance.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
Abstract
Dentin
hypersensitivity
(DH),
caused
by
the
exposure
of
dentin
tubules,
is
a
common
complaint
dental
patients.
Although
occlusion
exposed
tubules
primary
treatment
approach,
complex
oral
environment,
and
multiple
simultaneous
requirements
often
hinder
its
implementation.
In
this
study,
strawberry‐shaped
hemispheric
Janus
particles
(JPs)
are
synthesized,
their
use
in
DH
evaluated
vitro
an
animal
model.
The
side
JPs
modified
with
polymers
quaternary
ammonium
salts
(QASs)
to
form
superhydrophobic
coating
antibiofilm
properties,
while
flat
catechol
groups
able
strong
bonds
dentin.
Even
after
1
h
ultrasonication
or
1000
rounds
thermal
cycling,
completely
occluded
JPs.
Moreover,
biofilm
formation
not
observed,
area
living
bacteria
less
than
1%
compared
blank
control
sodium
fluoride
(NaF)‐treated
groups.
rat
model,
fixed
specimens
at
day
3,
much
earlier
obtained
commonly
used
NaF.
These
results
demonstrate
that
can
provide
novel
approach
DH.
