Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment DOI Creative Commons
Wenyao Zhen, Tomas Germanas, Ralph R. Weichselbaum

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(46)

Published: Aug. 15, 2024

Abstract Cholesterol is an essential membrane component, and the metabolites from cholesterol play important biological functions to intricately support cancer progression dampen immune responses. Preclinical clinical studies have demonstrated role of metabolism regulation on inhibiting tumor growth, remodeling immunosuppressive microenvironment (TME), enhancing anti‐tumor immunity. In this minireview, we discuss complex in tumors, its progression, influences cells TME. We provide overview recent advances treatment through regulating metabolism. design cholesterol‐altering multifunctional nanomaterials regulate oxidative stress, modulate checkpoints, manipulate mechanical stress responses, alter metabolic pathways. Additionally, examine interactions between established treatments with aim identifying efficient strategies disrupt synergistic combination therapies for effective treatment.

Language: Английский

Invasion and metastasis in cancer: molecular insights and therapeutic targets DOI Creative Commons

Yongxing Li,

Fengshuo Liu,

Qingjin Cai

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 20, 2025

The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.

Language: Английский

Citations

3
An Acceptor–Donor–Acceptor Structured Nano‐Aggregate for NIR‐Triggered Interventional Photoimmunotherapy of Cervical Cancer DOI

Gaoli Niu,

Xingqi Bi,

Yong Kang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 3, 2024

Compared with conventional therapies, photoimmunotherapy offers precise targeted cancer treatment minimal damage to healthy tissues and reduced side effects, but its efficacy may be limited by shallow light penetration the potential for tumor resistance. Here, an acceptor-donor-acceptor (A-D-A)-structured nanoaggregate is developed dual phototherapy, including photodynamic therapy (PDT) photothermal (PTT), triggered single near-infrared (NIR) light. Benefiting from strong intramolecular charge transfer (ICT), A-D-A-structured nanoaggregates exhibit broad absorption extending NIR region effectively suppressed fluorescence, which enables deep efficient conversion (η = 67.94%). A suitable HOMO-LUMO distribution facilitates sufficient intersystem crossing (ISC) convert ground-state oxygen (

Language: Английский

Citations

12
Metal‐Coordinated NIR‐II Nanoadjuvants with Nanobody Conjugation for Potentiating Immunotherapy by Tumor Metabolism Reprogramming DOI Creative Commons

Yeneng Dai,

Ziang Guo, Dongliang Leng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 7, 2024

Immune checkpoint blockade (ICB) immunotherapy remains hampered by insufficient immunogenicity and a high-lactate immunosuppressive tumor microenvironment (TME). Herein, nanobody-engineered NIR-II nanoadjuvant with targeting metabolic reprogramming capability is constructed for potentiating photothermal-ferroptosis immunotherapy. Specifically, the (2DG@FS-Nb) prepared metallic iron ion-mediated coordination self-assembly of D-A-D type molecules loading glycolysis inhibitor, 2-deoxy-D-glucose (2DG), followed modification aPD-L1 nanobody (Nb), which can effectively target TME trigger in situ immune blockade. The nanoadjuvants responsively release therapeutic components acidic TME, enabling precise location fluorescence/photoacoustic imaging while initiating therapy. remarkable photothermal efficiency elevated glutathione (GSH) depletion further sensitize ferroptosis to induce severe lipid peroxidation, provoking robust immunogenic cell death (ICD) anti-tumor response. Importantly, released 2DG markedly inhibits lactate generation through obstruction. Decreased efflux remodels suppressing M2 macrophage proliferation downregulating regulatory T levels. This work provides new paradigm integration phototheranostics metabolism regulation into single nanoplatform amplified combined ICB

Language: Английский

Citations

9
Mitochondria‐Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death‐1 Downregulation for Cancer Immunotherapy DOI Creative Commons
Youyou Li, Jing Liu, Ralph R. Weichselbaum

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

The combination of cuproptosis and immune checkpoint inhibition has shown promise in treating malignant tumors. However, it remains a challenge to deliver copper ions inhibitors efficiently simultaneously Herein, mitochondria-targeted nanoscale coordination polymer particle, Cu/TI, comprising Cu(II), triphenylphosphonium conjugate 5-carboxy-8-hydroxyquinoline (TI), for effective induction programmed cell death-1 (PD-L1) downregulation is reported. Upon systemic administration, Cu/TI accumulates tumor tissues induce immunogenic cancer death reduce PD-L1 expression. Consequently, promotes the intratumoral infiltration activation cytotoxic T lymphocytes greatly inhibit progression colorectal carcinoma triple-negative breast mouse models without causing obvious side effects.

Language: Английский

Citations

8
Nanotechnology-based in situ cancer vaccines: Mechanisms, design, and recent advances DOI

Gaoli Niu,

Hong Wang, Yanhong Zhai

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102286 - 102286

Published: May 6, 2024

Language: Английский

Citations

7
Personalized Nanovaccines Enhance Lymph Node Accumulation and Reprogram the Tumor Microenvironment for Improved Photodynamic Immunotherapy DOI
Ruoning Wang, Jinge Li, Xiaohong Wang

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(24), P. 7432 - 7442

Published: May 20, 2024

Tumor immunotherapy has emerged as an efficacious therapeutic approach that mobilizes the patient's immune system to achieve durable tumor suppression. Here, we design a photodynamic therapy-motivated nanovaccine (Dex-HDL/ALA-Fe

Language: Английский

Citations

7
Light‐Activated In Situ Vaccine with Enhanced Cytotoxic T Lymphocyte Infiltration and Function for Potent Cancer Immunotherapy DOI Creative Commons

Xian An,

Zhuang Chen, Yi Luo

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: July 2, 2024

In situ cancer vaccination is an attractive strategy that stimulates protective antitumor immunity. Cytotoxic T lymphocytes (CTLs) are major mediators of the adaptive immune defenses, with critical roles in response and establishing memory, consequently extremely important for vaccines to generate systemic lasting efficacy. However, dense extracellular matrix hypoxia solid tumors severely impede infiltration function CTLs, ultimately compromising efficacy vaccines. To address this issue, a robust vaccine, Au@MnO

Language: Английский

Citations

7
Nanomaterials: leading immunogenic cell death-based cancer therapies DOI Creative Commons

Changyu Ma,

Zhe Cheng, Haotian Tan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 9, 2024

The field of oncology has transformed in recent years, with treatments shifting from traditional surgical resection and radiation therapy to more diverse customized approaches, one which is immunotherapy. ICD (immunogenic cell death) belongs a class regulatory death modalities that reactivate the immune response by facilitating interaction between apoptotic cells releasing specific signaling molecules, DAMPs (damage-associated molecular patterns). inducers can elevate expression proteins optimize TME (tumor microenvironment). use nanotechnology shown its unique potential. Nanomaterials, due their tunability, targeting, biocompatibility, have become powerful tools for drug delivery, immunomodulators, etc., significant efficacy clinical trials. In particular, these nanomaterials effectively activate ICD, trigger potent anti-tumor response, maintain long-term tumor suppression. Different types nanomaterials, such as biological membrane-modified nanoparticles, self-assembled nanostructures, metallic mesoporous materials, hydrogels, play respective roles induction structures mechanisms action. Therefore, this review will explore latest advances application common discuss how they provide new strategies cancer therapy. By gaining deeper understanding mechanism action researchers develop precise effective therapeutic approaches improve prognosis quality life patients. Moreover, hold promise overcome resistance conventional therapies, minimize side effects, lead personalized treatment regimens, ultimately benefiting treatment.

Language: Английский

Citations

5
A Biomimetic Autophagosomes‐Based Nanovaccine Boosts Anticancer Immunity DOI
Liping Qu,

Guanhong Cui,

Yinping Sun

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Personalized cancer vaccines based on tumor cell lysates offer promise for immunotherapy yet fail to elicit a robust therapeutic effect due the weak immunogenicity of antigens. Autophagosomes, obtained from pleural effusions and ascites patients, have been identified as abundant reservoirs neoantigens that exhibit heightened immunogenicity. However, their potential personalized constrained by suboptimal lymphatic-targeting performances challenges in antigen-presenting endocytosis. Here,a reinforced biomimetic autophagosome-based (BAPs) nanovaccine generated precisely amalgamating autophagosome-derived two types adjuvants capable targeting lymph nodes is developed potently antitumor immunity. The redox-responsive BAPs facilitate cytosolic vaccine opening within cells, thereby exposing antigens stimulate strong immune response. evoke broad-spectrum T-cell responses, culminating effective eradication 71.4% established tumors. Notably, vaccination triggers enduring responses confer protection, with 100% mice shielded against rechallenge significant reduction incidence 87.5%. Furthermore, synergize checkpoint blockade therapy inhibit growth poorly immunogenic breast model. approach presents powerful formula high versatility immunotherapy.

Language: Английский

Citations

5
Wide‐Spectrum Nano‐Antibiotics Based on TPA‐Py@AuNCs⊂BSA for Multimodal Synergistic Therapy of Drug‐Resistant Bacteria and Wound Infections DOI Creative Commons

Fengrui Xu,

Ge Zhang, Kai Zhang

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

ABSTRACT To meet the high requirements of biomedical applications in antimicrobial agents, it is crucial to explore efficient nano‐antimicrobial agents with no resistance and good biocompatibility for treating infected wounds. In this study, composite nano‐antibiotic TPA‐Py@AuNCs⊂BSA nanoparticles (TAB NPs) are prepared using hollow mesoporous Au nanocages (AuNCs) loaded a photosensitizer (namely TPA‐Py) D‐π‐A structure showing aggregation‐induced emission properties. When TPA‐Py encapsulated cavity AuNCs, its fluorescence suppressed. presence photothermal induction, can be released from allowing restoration illumination specific imaging Gram‐positive bacteria. TAB NPs demonstrate outstanding activity against variety bacteria, multimodal property does not lead development bacterial resistance. vitro experiments show that could eliminate bacteria ablate biofilm. vivo synergistic effect has significant positive impact on treatment wounds, including rapid antibacterial action, promotion M2 macrophage polarization, enhancement chronic wound healing. This study provides an effective strategy developing wide‐spectrum nano‐antibiotics ablation biofilms

Language: Английский

Citations

4