Materials Today, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)
Published: Feb. 16, 2024
Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells controlled manner. Immunomodulatory hydrogels present unique capability augmenting immune activation mitigating systemic toxicity through encapsulation multiple components localized administration. Notably, based on biopolymers have gained significant interest owing their biocompatibility, environmental friendliness, ease production. This review delves into the recent advances bio-based immunotherapy synergistic combinatorial approaches, highlighting diverse applications. It is anticipated that this will guide rational design field immunotherapy, fostering clinical translation ultimately benefiting patients.
Language: Английский
Citations
22
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 7, 2025
Antibiotic resistance is currently one of the most significant threats to global public health and safety. And studies have found that over next 25 years, 39 million people will die directly 169 indirectly due antibiotic-resistant diseases. Consequently, development new types antimicrobial drugs urgently needed. Antimicrobial peptides (AMPs) constitute an essential component innate immune response in all organisms. They exhibit a distinctive mechanism action endows them with broad spectrum biological activities, including antimicrobial, antibiofilm, antiviral, anti-inflammatory effects. However, AMPs also present certain limitations, such as cytotoxicity, susceptibility protein hydrolysis, poor pharmacokinetic properties, which impeded their clinical application. The delivery systems can address these challenges by modifying AMP enabling precise, controlled release at site infection or disease. This review offers comprehensive analysis mechanisms advantages AMPs. systematically evaluate how emerging drug systems, nanoparticles hydrogels, enhance stability bioavailability AMPs, discussing both strengths limitations. Moreover, unlike previous reviews, this highlight recent clinically approved AMP-based those development, emphasizing key translating into practice. With perspectives, it hoped provide some insights overcoming translational barriers advancing
Language: Английский
Citations
3
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
This tutorial review presents the development of advanced immunomodulatory hydrogels strategically designed to address chronic inflammation through their intrinsic properties.
Language: Английский
Citations
10
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 31, 2025
The impact of chirality on immune response has attracted great interest in cancer vaccine research recently. However, the study chiral synthetic polypeptide hydrogels as vaccines well biomaterials themselves for antitumor immunotherapy rarely been reported. Here, we show key role residue immunity and local microenvironment regulation. Compared to poly(γ-ethyl-L-glutamate)-based (L-Gel), poly(γ-ethyl-D-glutamate)-based (D-Gel) induces enhanced level cell infiltration. D-Gel causes higher levels suppressive markers antigen-presenting cells even stronger T exhaustion than L-Gel. Finally, establishes a chronic inflammatory immunosuppressive shows insufficient anti-tumor effects. Conversely, milder host responses induced by L-Gel leads more effective tumor inhibition. This provides insights regulation affecting response. chemical attracts attention design Here this group reports hydrogel exhibiting suppression inducing eventually leading efficacy.
Language: Английский
Citations
1
Journal of Tissue Engineering, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 1, 2024
Diabetic wound healing presents a significant clinical challenge due to the interplay of systemic metabolic disturbances and local inflammation, which hinder process. Macrophages undergo phenotypic shift from M1 M2 during healing, transition pivotal for effective tissue repair. However, in diabetic wounds, microenvironment disrupts this polarization, perpetuating impeding healing. Reprograming macrophages restore their phenotype offers potential avenue modulating immune promoting This review elucidates mechanisms underlying impaired macrophage polarization toward wounds discusses novel strategies, including epigenetic interventions, promote conversion M2. Hydrogels, with hydrated 3D cross-linked structure, closely resemble physiological extracellular matrix offer advantageous properties such as biocompatibility, tunability, versatility. These characteristics make hydrogels promising candidates developing immunomodulatory materials aimed at addressing wounds. Understanding role immunotherapy, particularly context reprograming, is essential development advanced care solutions. also highlights recent advancements immunotherapeutic step precise treatments
Language: Английский
Citations
5
Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(12), P. 2993 - 3008
Published: Jan. 1, 2024
Peptides are a class of active substances composed variety amino acids with special physiological functions.
Language: Английский
Citations
4
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4007 - 4019
Published: May 1, 2024
Introduction: Nanosized outer membrane vesicles (OMVs) from Gram-negative bacteria have attracted increasing interest because of their antitumor activity. However, the effects MVs isolated Gram-positive rarely been investigated. Methods: Staphylococcus aureu s USA300 were prepared and efficacy was evaluated using tumor-bearing mouse models. A gene knock-in assay performed to generate luciferase Antares2–MVs for bioluminescent detection. Cell counting kit-8 lactic dehydrogenase release assays used detect toxicity against tumor cells in vitro. Active caspase-1 gasdermin D (GSDMD) levels determined Western blot, inhibition ability B16F10 treated with a inhibitor. Results: The vesicular particles S. aureus 55.23 ± 8.17 nm diameter, 5 μg remarkably inhibited growth melanoma C57BL/6 mice CT26 colon adenocarcinoma BALB/c mice. signals correlated well concentrations engineered (R 2 = 0.999), sensitivity bioluminescence imaging 4 × 10 − 3 μg. can directly target tissues vivo, 20 μg/mL considerably reduced cells, but not non-carcinomatous bEnd.3 cells. MV treatment substantially increased level active caspase-1, which processes GSDMD trigger pyroptosis Blocking activation VX-765 significantly protected killing vitro vivo. Conclusion: kill by activating pathway, induction is promising strategy cancer treatment. Keywords: , vesicles, Antares2, therapy, pyroptosis,
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5152 - 5152
Published: May 9, 2024
Cancer immunotherapy relies on the insight that immune system can be used to defend against malignant cells. The aim of cancer is utilize, modulate, activate, and train amplify antitumor T-cell immunity. In parallel, response damaged tissue also crucial in determining success or failure an implant. Due their extracellular matrix mimetics tunable chemical physical performance, hydrogels are promising platforms for building immunomodulatory microenvironments realizing therapy regeneration. However, submicron nanosized pore structures within not favorable modulating cell function, such as invasion, migration, immunophenotype. contrast, with a porous structure only allow nutrient transportation metabolite discharge but offer more space function. this review, design strategies influencing factors regeneration first discussed. Second, effects therapeutic outcomes different highlighted. Beyond that, review highlights size function potential signal transduction. Finally, remaining challenges perspectives
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137047 - 137047
Published: Nov. 1, 2024
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159621 - 159621
Published: Jan. 15, 2025
Language: Английский
Citations
0