Gold Nanozymes: From Concept to Biomedical Applications DOI Creative Commons
Javier Lou-Franco, Bhaskar Das, Christopher T. Elliott

et al.

Nano-Micro Letters, Journal Year: 2020, Volume and Issue: 13(1)

Published: Oct. 27, 2020

Abstract In recent years, gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase, oxidase, catalase, superoxide dismutase or reductase. This, merged with their ease synthesis, tunability, biocompatibility and low cost, makes them candidates when compared biological enzymes for applications in biomedicine biochemical analyses. Herein, over 200 research papers been systematically reviewed to present the progress on fundamentals nanozymes potential applications. The review reveals that morphology surface chemistry play an important role catalytic properties, as well external parameters such pH temperature. Yet, real often require specific biorecognition elements be immobilized onto nanozymes, leading unexpected positive negative effects activity. Thus, rational design efficient remains a challenge paramount importance. Different implementation paths already explored, including application peroxidase-like development clinical diagnostics regulation oxidative stress within cells via catalase activities. also indicates it is essential understand how may boost inhibit each these activities, more than one could coexist. Likewise, further toxicity studies are required ensure applicability vivo. Current challenges future prospects discussed this review, whose significance can anticipated diverse range fields beyond biomedicine, food safety, environmental analyses chemical industry.

Language: Английский

Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy DOI Creative Commons
Shutao Gao,

Yan Jin,

Kun Ge

et al.

Advanced Science, Journal Year: 2019, Volume and Issue: 6(24)

Published: Oct. 24, 2019

Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H

Language: Английский

Citations

319
Recent Advances in Nanozymes: From Matters to Bioapplications DOI
Yongjian Ai, Zenan Hu, Xiaoping Liang

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(14)

Published: Dec. 16, 2021

Abstract The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one subcategories biomimetic materials, development artificial enzyme is intensive pursuing. a kind enzyme, nanozymes are dedicated solve limitations enzymes. In recent years, attributed explosive nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on made great progress. To highlight these achievements help researchers understand current investigation status nanozyme, state‐of‐the‐art in from fabrication bioapplications summarized. First different raw summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, some other novel matters, which applied fabricate nanozymes. types enzymes‐like catalytic activities briefly discussed. Subsequently, wide applications such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, bioimaging Finally, challenges faced by outlined future directions for advancing nanozyme outlooked. authors hope this review can inspire fields chemistry, biology, theoretical computing, contribute

Language: Английский

Citations

317
Single‐Atom Catalysts in Catalytic Biomedicine DOI
Huijing Xiang, Wei Feng, Yu Chen

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(8)

Published: Jan. 13, 2020

The intrinsic deficiencies of nanoparticle-initiated catalysis for biomedical applications promote the fast development alternative versatile theranostic modalities. catalytic performance and selectivity are critical issues that challenging to be augmented optimized in biological conditions. Single-atom catalysts (SACs) featuring atomically dispersed single metal atoms have emerged as one most explored biomedicine recently due their preeminent activity superior distinct from nanosized counterparts. Herein, an overview pivotal significance SACs some underlying need addressed is provided, with a specific focus on applications. Their fabrication strategies, surface engineering, structural characterizations discussed briefly. In particular, triggering representative reactions providing fundamentals use discussed. A sequence paradigms summarized successful construction varied (e.g., cancer treatment, wound disinfection, biosensing, oxidative-stress cytoprotection) emphasis uncovering mechanisms understanding structure–performance relationships. Finally, opportunities challenges faced future SACs-triggered outlooked.

Language: Английский

Citations

314
Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapy DOI
Bolong Xu,

Yan Cui,

Weiwei Wang

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(33)

Published: July 6, 2020

Abstract Nanozyme‐based tumor catalytic therapy has attracted widespread attention in recent years. However, its therapeutic outcomes are diminished by many factors the microenvironment (TME), such as insufficient endogenous hydrogen peroxide (H 2 O ) concentration, hypoxia, and immunosuppressive microenvironment. Herein, an immunomodulation‐enhanced nanozyme‐based strategy is first proposed to achieve synergism between nanozymes TME regulation. TGF‐β inhibitor (TI)‐loaded PEGylated iron manganese silicate nanoparticles (IMSN) (named IMSN‐PEG‐TI) constructed trigger modality. The results show that IMSN nanozyme exhibits both intrinsic peroxidase‐like catalase‐like activities under acidic TME, which can decompose H into hydroxyl radicals (•OH) oxygen (O ), respectively. Besides, it demonstrated TI regulate immune microenvironment, resulting macrophage polarization from M2 M1, thus inducing regeneration of , promote nanozyme. potent antitumor effect IMSN‐PEG‐TI proved vitro multicellular spheroids (MCTS) vivo CT26‐tumor‐bearing mice models. It believed treatment a promising tool kill cancer cells.

Language: Английский

Citations

309
The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment DOI Open Access
Xue Bai, Yueying Wang, Zhiyun Song

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(7), P. 2480 - 2480

Published: April 3, 2020

Gold nanoparticles (AuNPs) have been widely studied and applied in the field of tumor diagnosis treatment because their special fundamental properties. In order to make AuNPs more suitable for treatment, natural properties interrelationships between these should be systematically profoundly understood. The were discussed from two aspects: physical chemical. Among AuNPs, localized surface plasmon resonance (LSPR), radioactivity high X-ray absorption coefficient are used tumors. As an advantage over many other chemicals, can form stable chemical bonds with S-and N-containing groups. This allows attach a wide variety organic ligands or polymers specific function. These modifications endow outstanding biocompatibility, targeting drug delivery capabilities. this review, we summarized physicochemical intrinsic relationships. Then latest research advancements developments basic clinical trials using summarized. Further, difficulties overcome possible solutions process laboratory application discussed. Finally, possibility applying results was estimated. We hope provide reference peer researchers better utilize excellent gold oncotherapy.

Language: Английский

Citations

303
Nanozymes-Engineered Metal–Organic Frameworks for Catalytic Cascades-Enhanced Synergistic Cancer Therapy DOI
Chuang LIU, Jie Xing, Ozioma Udochukwu Akakuru

et al.

Nano Letters, Journal Year: 2019, Volume and Issue: 19(8), P. 5674 - 5682

Published: July 30, 2019

The efficiency of chemical intercommunication between enzymes in natural networks can be significantly enhanced by the organized catalytic cascades. Nevertheless, exploration two-or-more-enzymes-engineered nanoreactors for cascades remains a great challenge cancer therapy because inherent drawbacks enzymes. Here, encouraged activity individual nanozyme benefiting treatment solid tumors, we propose an situ cascades-enhanced synergistic therapeutic strategy driven dual-nanozymes-engineered porphyrin metal–organic frameworks (PCN). Precisely, catalase-mimicking platinum nanoparticles (Pt NPs) were sandwiched PCN, followed embedding glucose oxidase-mimicking ultrasmall gold (Au within outer shell, and further coordination with folic acid (P@Pt@P–Au–FA). Pt NPs effectively enabled tumor hypoxia relief catalyzing intratumoral H2O2 to O2 (1) enhancing O2-dependent photodynamic (2) subsequently accelerating depletion β-d-glucose Au starving-like self-produced as substrate NPs. Consequently, remarkably strengthened antitumor prevention recurrence metastasis was achieved. This work highlights rationally designed microenvironment-specific nanoreactor opening improved research nanozymes provides means design cascade model practical applications.

Language: Английский

Citations

301
Nanozymes-recent development and biomedical applications DOI Creative Commons
Xiangyi Ren, Dongxu Chen, Yan Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Feb. 22, 2022

Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed the catalytic reactions natural enzymes. In field biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic be regulated by multiple factors, such as chemical state metal ion, pH, hydrogen peroxide (H2O2), glutathione (GSH) level, presenting great promise for biomedical applications. Over past decade, multi-functional have been developed various To promote understandings development novel multifunctional nanozymes, we herein provide comprehensive review applications in field. Nanozymes versatile enzyme-like properties briefly overviewed, mechanism application discussed future research. Finally, underlying challenges prospects frontier this review.

Language: Английский

Citations

272
Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment DOI
Chenyang Zhang, Xin Wang, Jiangfeng Du

et al.

Advanced Science, Journal Year: 2020, Volume and Issue: 8(3)

Published: Dec. 20, 2020

Abstract Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving topics ROS‐regulating therapy such as antioxidant triggered by scavengers ROS‐induced toxic mediated ROS‐elevation agents. Benefiting from remarkable advances nanotechnology, a large number nanomaterials with ability are developed to seek new effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements been made ROS‐based nanomedicines treatments, some fundamental but key questions rational design principle held low regard. Here, can serve initial framework scientists technicians optimize nanomedicines, thereby minimizing gap biomedical application during stage. Herein, overview current progress ROS‐associated is summarized. And then, particularly addressing these known strategies therapy, several principles presented. Finally, future perspectives also discussed depth development

Language: Английский

Citations

271
Photodynamic therapy for hypoxic tumors: Advances and perspectives DOI
Huang Li,

Shaojing Zhao,

Jiasheng Wu

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 438, P. 213888 - 213888

Published: March 16, 2021

Language: Английский

Citations

258
Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies DOI Creative Commons
Hailong Tian, Tingting Zhang, Siyuan Qin

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Sept. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Language: Английский

Citations

246