Theranostics,
Journal Year:
2020,
Volume and Issue:
10(22), P. 10106 - 10119
Published: Jan. 1, 2020
Ulcerative
colitis
(UC)
is
featured
with
relapsing
inflammation
in
the
colon,
where
macrophages
are
recruited
and
polarized
locally
into
M1
type
to
drive
further
inflammation.
Pharmacotherapy
of
UC
has
exhibited
limited
efficacy,
mostly
due
poor
specificity.
Methods:
A
macrophage-biomimetic
nanomedicine
was
developed
for
targeted
treatment
UC,
which
derived
from
reactive
oxygen
species
(ROS)-sensitive
β-cyclodextrin,
loaded
rosiglitazone,
coated
macrophage
membrane.
The
ability
regulating
polarization
examined
at
cellular
level,
macrophage-tropism
driven
delivery
inflammatory
colon
investigated
by
ex
vivo
bio-imaging
distribution
assay.
Furthermore,
nanomedicine's
therapeutic
efficacy
systemically
dextran
sulfate
sodium
(DSS)-induced
model
mice.
Results:
effectively
M2
protected
epithelial
cells
oxidative
stress
vitro.
In
addition,
macrophage-membrane
led
a
high
targeting
efficiency.
response
elevated
ROS
tissue,
released
rosiglitazone
specifically
regulated
vivo.
Macrophage
membrane
also
assisted
suppression
sequestering
proinflammatory
cytokines.
Working
such
synergy,
significant
effects
against
Conclusions:
This
leverages
tropism
cytokine
sequestration
local
suppression,
ROS-responsiveness
β-cyclodextrin-based
matrix
specific
payload
release,
macrophage-polarizing
effect
regulation,
thereby
exhibiting
considerable
study
offers
important
new
insights
on
design
development
biomimetic
nanomaterials
regulations.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
33(4)
Published: Dec. 4, 2020
Abstract
Micro‐/nanorobots
(m‐bots)
have
attracted
significant
interest
due
to
their
suitability
for
applications
in
biomedical
engineering
and
environmental
remediation.
Particularly,
vivo
diagnosis
intervention
been
the
focus
of
extensive
research
recent
years
with
various
clinical
imaging
techniques
being
applied
localization
tracking.
The
successful
integration
well‐designed
m‐bots
surface
functionalization,
remote
actuation
systems,
becomes
crucial
step
toward
applications,
especially
uses.
This
review
thus
addresses
four
different
aspects
m‐bots:
design/fabrication,
actuation,
localization.
diagnosis,
sensing,
microsurgery,
targeted
drug/cell
delivery,
thrombus
ablation,
wound
healing
are
reviewed
from
these
viewpoints.
developed
m‐bot
systems
comprehensively
compared
evaluated
based
on
characteristics.
current
challenges
directions
future
this
field
summarized.
Theranostics,
Journal Year:
2020,
Volume and Issue:
11(1), P. 164 - 180
Published: Oct. 9, 2020
Atherosclerosis
(AS),
the
underlying
cause
of
most
cardiovascular
events,
is
one
common
causes
human
morbidity
and
mortality
worldwide
due
to
lack
an
efficient
strategy
for
targeted
therapy.
In
this
work,
we
aimed
develop
ideal
biomimetic
nanoparticle
AS
Methods:
Based
on
macrophage
"homing"
into
atherosclerotic
lesions
cell
membrane
coating
nanotechnology,
nanoparticles
(MM/RAPNPs)
were
fabricated
with
a
(MM)
surface
rapamycin-loaded
poly
(lactic-co-glycolic
acid)
copolymer
(PLGA)
(RAPNPs).
Subsequently,
physical
properties
MM/RAPNPs
characterized.
The
biocompatibility
biological
functions
determined
in
vitro.
Finally,
mouse
models,
targeting
characteristics,
therapeutic
efficacy
safety
examined.
Results:
advanced
demonstrated
good
biocompatibility.
Due
MM
coating,
effectively
inhibited
phagocytosis
by
macrophages
activated
endothelial
cells
addition,
MM-coated
accumulated
vivo.
After
4-week
treatment
program,
shown
significantly
delay
progression
AS.
Furthermore,
displayed
favorable
performance
after
long-term
administration.
Conclusion:
These
results
demonstrate
that
could
efficiently
safely
inhibit
may
be
potential
drug
delivery
systems
safe
effective
anti-AS
applications.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Sept. 30, 2021
Cell
membrane
coated
nanoparticles
(NPs)
have
recently
been
recognized
as
attractive
nanomedical
tools
because
of
their
unique
properties
such
immune
escape,
long
blood
circulation
time,
specific
molecular
recognition
and
cell
targeting.
However,
the
integrity
coating
on
NPs,
a
key
metrics
related
to
quality
these
biomimetic-systems
resulting
biomedical
function,
has
remained
largely
unexplored.
Here,
we
report
fluorescence
quenching
assay
probe
coating.
In
contradiction
common
assumption
perfect
coating,
uncover
that
up
90%
biomimetic
NPs
are
only
partially
coated.
Using
in
vitro
homologous
targeting
studies,
demonstrate
could
still
be
internalized
by
target
cells.
By
combining
simulations
with
experimental
analysis,
further
identify
an
endocytic
entry
mechanism
for
NPs.
We
unravel
high
degree
(≥50%)
enter
cells
individually,
whereas
low
(<50%)
need
aggregate
together
before
internalization.
This
quantitative
method
fundamental
understanding
how
will
enhance
rational
designing
nanosystems
pave
way
more
effective
cancer
nanomedicine.
Advanced Science,
Journal Year:
2019,
Volume and Issue:
6(22)
Published: Sept. 12, 2019
Abstract
Photodynamic
therapy
(PDT)
is
clinically
promising
in
destructing
primary
tumors
but
ineffective
against
distant
metastases.
This
study
reports
the
use
of
immunogenic
nanoparticles
mediated
combination
PDT
and
magnetic
hyperthermia
to
synergistically
augment
anti‐metastatic
efficacy
immunotherapy.
Janus
nanobullets
integrating
chlorine
e6
(Ce6)
loaded,
disulfide‐bridged
mesoporous
organosilica
bodies
with
heads
(M‐MONs@Ce6)
are
tailored
for
redox/pH‐triggered
photosensitizer
release
accompanying
their
matrix
degradation.
Cancer
cell
membrane
cloaking
enables
favorable
tumor‐targeted
accumulation
prolonged
blood
circulation
time
M‐MONs@Ce6.
The
has
a
strong
synergy
anticancer
activity
simultaneously
elicits
sequence
death,
resulting
tumor‐specific
immune
responses.
When
combined
anti‐CTLA‐4
antibody,
biomimetic
biodegradable
nanoparticle
notable
eradication
deeply
metastatic
low
systematic
toxicity,
thus
potentially
advancing
development
hyperthermia,
PDT,
checkpoint
blockade
immunotherapy
combat
cancer
metastasis.
Advanced Science,
Journal Year:
2019,
Volume and Issue:
6(15)
Published: May 22, 2019
Abstract
Inflammation
is
ubiquitous
in
the
body,
triggering
desirable
immune
response
to
defend
against
dangerous
signals
or
instigating
undesirable
damage
cells
and
tissues
cause
disease.
Nanomedicine
holds
exciting
potential
modulating
inflammation.
In
particular,
cell
membranes
derived
from
involved
inflammatory
process
may
be
used
coat
nanotherapeutics
for
effective
targeted
delivery
tissues.
Herein,
recent
progress
of
rationally
engineering
membrane‐based
inflammation
therapy
highlighted,
challenges
opportunities
presented
realizing
full
cell‐membrane
coating
targeting
manipulating
microenvironment
are
discussed.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(50)
Published: Nov. 9, 2020
Chemotherapy
causes
off-target
toxicity
and
is
often
ineffective
against
solid
tumors.
Targeted
on-demand
release
of
chemotherapeutics
remains
a
challenge.
Here,
cancer-cell-membrane-coated
mesoporous
organosilica
nanoparticles
(MONs)
containing
X-ray-
reactive
oxygen
species
(ROS)-responsive
diselenide
bonds
for
controlled
doxorubicin
(DOX)
at
tumor
sites
are
developed.
DOX-loaded
MONs
coated
with
4T1
breast
cancer
cell
membranes
(CM@MON@DOX)
show
greater
accumulation
prolonged
blood
circulation
time
versus
an
uncoated
control
in
mice
bearing
orthotopic
mammary
Under
low-dose
X-ray
radiation,
the
exhibit
carrier
degradation-controlled
via
cleavage
bonds,
resulting
DOX-mediated
immunogenic
death
site.
Combination
PD-L1
checkpoint
blockade
further
enhances
inhibition
growth
metastasis
low
systemic
toxicity.
Together,
findings
promise
these
biomimetic,
radiation-responsive
diselenide-bond-bridged
chemo-immunotherapy.
